Biotin/ja: Difference between revisions

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* [[Propionyl-CoA carboxylase/ja|プロピオニル-CoAカルボキシラーゼ]]（PCC）

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~~For the first two, biotin serves as a~~ [[~~Cofactor (biochemistry)~~|~~cofactor~~]] ~~responsible for transfer of~~ [[~~bicarbonate~~]] to [[~~acetyl-CoA~~]]~~, converting it to~~ [[malonyl-CoA]] ~~for~~ [[~~fatty acid synthesis~~]]~~. PC participates in~~ [[gluconeogenesis]]~~. MCC catalyzes a step in~~ [[leucine]] ~~metabolism. PCC catalyzes a step in the metabolism of~~ [[propionyl-CoA]]~~. Metabolic degradation of the~~ [[biotinylation|~~biotinylated~~]] ~~carboxylases leads to the formation of~~ [[biocytin]]~~. This compound is further degraded by biotinidase to release biotin, which is then reutilized by holocarboxylase synthetase.~~

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核内クロマチンにおける[[histone/ja|ヒストン]]タンパク質のビオチン化は、クロマチンの安定性と遺伝子発現に関与する[[posttranslational modification/ja|翻訳後修飾]]である。

~~Biotinylation of~~ [[histone]] ~~proteins in nuclear chromatin is a~~ [[posttranslational modification]] ~~that plays a role in chromatin stability and gene expression.~~

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 * [[Propionyl-CoA carboxylase/ja|プロピオニル-CoAカルボキシラーゼ]]（PCC）
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+最初の2つについては、ビオチンは[[bicarbonate/ja|炭酸水素塩]]を[[acetyl-CoA/ja|アセチル-CoA]]に移動させ、[[fatty acid synthesis/ja|脂肪酸合成]]のための[[malonyl-CoA/ja|マロニル-CoA]]に変換する役割を担う[[Cofactor (biochemistry)/ja|補因子]]として機能する。PCは[[gluconeogenesis/ja|糖新生]]に関与する。MCCは[[leucine/ja|ロイシン]]代謝の一段階を触媒する。PCCは[[propionyl-CoA/ja|プロピオニル-CoA]]の代謝の一段階を触媒する。[[biotinylation/ja|ビオチン化]]カルボキシラーゼの代謝分解は[[biocytin/ja|ビオシチン]]の形成をもたらす。この化合物はビオチニダーゼによってさらに分解されてビオチンを放出し、ホロカルボキシラーゼ合成酵素によって再利用される。
-For the first two, biotin serves as a [[Cofactor (biochemistry)|cofactor]] responsible for transfer of [[bicarbonate]] to [[acetyl-CoA]], converting it to [[malonyl-CoA]] for [[fatty acid synthesis]]. PC participates in [[gluconeogenesis]]. MCC catalyzes a step in [[leucine]] metabolism. PCC catalyzes a step in the metabolism of [[propionyl-CoA]]. Metabolic degradation of the [[biotinylation|biotinylated]] carboxylases leads to the formation of [[biocytin]]. This compound is further degraded by biotinidase to release biotin, which is then reutilized by holocarboxylase synthetase.
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+核内クロマチンにおける[[histone/ja|ヒストン]]タンパク質のビオチン化は、クロマチンの安定性と遺伝子発現に関与する[[posttranslational modification/ja|翻訳後修飾]]である。
-Biotinylation of [[histone]] proteins in nuclear chromatin is a [[posttranslational modification]] that plays a role in chromatin stability and gene expression.
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