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Prosultiamine/ja: Difference between revisions

Prosultiamine/ja
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Created page with "プロスルチアミン"
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{{Short description|Chemical compound}}
{{Drugbox
{{Drugbox
| IUPAC_name = ''N''-[(4-amino-2-methylpyrimidin-5-yl)methyl]-''N''-[(1''E'')-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide
| IUPAC_name = ''N''-[(4-amino-2-methylpyrimidin-5-yl)methyl]-''N''-[(1''E'')-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide
| image = Prosultiamine.png
| image = Prosultiamine.png
| alt = Skeletal formula of prosultiamine
| alt = プロスルチアミンの骨格式
| width = 240
| width = 240
| image2 = Prosultiamine 3D ball.png
| image2 = Prosultiamine 3D ball.png
| alt2 = Ball-and-stick model of the prosultiamine molecule
| alt2 = プロスルチアミン分子のボール＆スティックモデル
| width2 = 260
| width2 = 260
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<!--Clinical data-->
<!--Clinical data-->
| tradename =   
| tradename =   
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| legal_status = Rx-only
| legal_status = Rx-only
| routes_of_administration = [[Mouth|Oral]]
| routes_of_administration = [[Mouth|Oral]]
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<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
| bioavailability =   
| bioavailability =   
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| elimination_half-life =   
| elimination_half-life =   
| excretion =
| excretion =
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<!--Identifiers-->
<!--Identifiers-->
| CAS_number = 59-58-5
| CAS_number = 59-58-5
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| UNII_Ref = {{fdacite|correct|FDA}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = UI32MM3XE3
| UNII = UI32MM3XE3
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<!--Chemical data-->
<!--Chemical data-->
| C=15 | H=24 | N=4 | O=2 | S=2  
| C=15 | H=24 | N=4 | O=2 | S=2  
| smiles = O=CN(\C(=C(\SSCCC)CCO)C)Cc1cnc(nc1N)C
| smiles = O=CN(\C(=C(\SSCCC)CCO)C)Cc1cnc(nc1N)C
}}
}}
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'''プロスルチアミン'''（[[:en:International Nonproprietary Name|INN]]、別名'''チアミンプロピルジスルフィド'''または'''TPD'''、商品名'''ジュベデル'''）は、1950年代に[[:ja:日本|日本]]のニンニクから発見された[[disulfide/ja|ジスルフィド]][[thiamine/ja|チアミン]][[derivative (chemistry)/ja|誘導体]]である。[[allithiamine/ja|アリチアミン]]に類似している。[[Thiamine/ja#Deficiency|ビタミンB<sub>1</sub>欠乏症]]の治療薬として開発された。[[lipid/ja|脂質]][[solubility/ja|溶解性]]が改善されており、吸収のための腸管[[membrane transport protein/ja|トランスポーター]]への依存による速度制限がないことが開発の理由である。
'''Prosultiamine''' ([[International Nonproprietary Name|INN]]; also known as '''thiamine propyl disulfide''' or '''TPD'''; brand name '''Jubedel''',) is a [[disulfide]] [[thiamine]] [[derivative (chemistry)|derivative]] discovered in garlic in [[Japan]] in the 1950s, and is similar to [[allithiamine]]. It was developed as a treatment for [[Thiamine#Deficiency|vitamin B<sub>1</sub> deficiency]]. It has improved [[lipid]] [[solubility]] relative to thiamine and is not rate-limited by dependency on intestinal [[membrane transport protein|transporter]]s for absorption, hence the reasoning for its development.
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==研究==
==Research==
{{Anchor|Research}}
It has been studied as a potential treatment for infection with [[human T-lymphotropic virus]] (HTLV), since it has been shown to reduce viral load and symptoms.
[[human T-lymphotropic virus/ja|ヒトTリンパ向性ウイルス]]（HTLV）に感染した場合の治療法として研究されており、ウイルス量と症状を減少させることが示されている。
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== こちらも参照 ==
== See also ==
* [[Vitamin B1 analogue/ja|ビタミンB<sub>1</sub>類似体]]
* [[Vitamin B1 analogue|Vitamin B<sub>1</sub> analogue]]
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{{Vitamins/ja}}
{{Vitamins}}
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{{二次利用|date=2 March 2024}}
[[Category:Formamides]]
[[Category:Formamides]]
[[Category:Organic disulfides]]
[[Category:Organic disulfides]]
[[Category:Aminopyrimidines]]
[[Category:Aminopyrimidines]]
[[Category:Thiamine]]
[[Category:Thiamine]]
</div>
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