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Tacalcitol/ja: Difference between revisions

Tacalcitol/ja
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Created page with "タカルシトール"
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Created page with "{{Antipsoriatics/ja}} {{Vitamin D receptor modulators/ja}}"
 
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{{Short description|Chemical compound}}
{{Drugbox
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| IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol
| IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol
| image = Tacalcitol.svg
| image = Tacalcitol.svg
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| routes_of_administration = Topical
| routes_of_administration = Topical
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| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number_Ref = {{cascite|correct|??}}
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID      = 4446823
| ChemSpiderID      = 4446823
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| C=27 | H=44 | O=3  
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| StdInChIKey      = BJYLYJCXYAMOFT-RSFVBTMBSA-N
| StdInChIKey      = BJYLYJCXYAMOFT-RSFVBTMBSA-N
}}
}}
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'''タカルシトール'''（'''Tacalcitol'''）（1,24-dihydroxyvitamin D<sub>3</sub>）は合成[[vitamin D3|ビタミンD<sub>3</sub>]]類似体である。タカルシトールは'''Curatoderm'''や'''Bonalfa'''などの名称で販売されている。
'''Tacalcitol''' (1,24-dihydroxyvitamin D<sub>3</sub>) is a synthetic [[vitamin D3|vitamin D<sub>3</sub>]] analog. Tacalcitol is marketed under several names, including '''Curatoderm''' and '''Bonalfa'''.
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[[WHO Model List of Essential Medicines/ja|世界保健機関の必須医薬品リスト]]に掲載されている。
It is on the [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].
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==メカニズム{{Anchor|Mechanism}}==
==Mechanism==
タカルシトールは、[[keratinocytes/ja|ケラチノサイト]]上の[[vitamin D receptor/ja|ビタミンD受容体]]と相互作用することによって、表皮の過剰な細胞のターンオーバーを抑える。
Tacalcitol reduces excessive cell turnover in the epidermis by interacting with [[vitamin D receptor]]s on [[keratinocytes]].
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==用途{{Anchor|Uses}}==
==Uses==
皮膚細胞の過剰なターンオーバーを抑える作用があるため、通常、[[psoriasis/ja|乾癬]]や慢性[[chapped lips/ja|ひび割れ唇]]などの重度の乾燥肌の治療薬として、開業医や皮膚科医から処方される。軟膏またはローションとして入手できる。
It is usually prescribed by a general practitioner or dermatologist for the treatment of [[psoriasis]], chronic [[chapped lips]] and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover. It is available as an ointment or lotion.
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また、[[vitiligo/ja|白斑]]や[[Hailey-Hailey disease/ja|ハイリーハイリー病]]にも使用されている。
It has also been used for [[vitiligo]] and [[Hailey-Hailey disease]].
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{{Antipsoriatics/ja}}
{{Antipsoriatics}}
{{Vitamin D receptor modulators/ja}}
{{Vitamin D receptor modulators}}
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{{二次利用|date=11 February 2024}}
[[Category:Secosteroids]]
[[Category:Secosteroids]]
[[Category:Vitamin D]]
[[Category:Vitamin D]]
{{Vitamins}}
{{Vitamins/ja}}
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