Pyritinol/ja: Difference between revisions

Pyritinol/ja
Clinical data
ATC code	N06BX02 (WHO) ;
Pharmacokinetic data
Elimination half-life	2.5 hours
Identifiers
	IUPAC name 5,5'-[dithiobis(methylene)]bis[4-(hydroxymethyl)-2-methylpyridin-3-ol];
CAS Number	1098-97-1 ;
PubChem CID	14190;
ChemSpider	13561 ;
UNII	AK5Q5FZH2R;
KEGG	D02160 ;
ChEMBL	ChEMBL488093 ;
Chemical and physical data
Formula	C16H20N2O4S2
Molar mass	368.47 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1c(c(cnc1C)CSSCc2c(c(O)c(nc2)C)CO)CO;
	InChI InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3 ; Key:SIXLXDIJGIWWFU-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 16:10, 4 April 2024

ピリチノール（Pyritinol）は、ピリドキシンジスルフィドまたはピリチオキシン（欧州薬物名Encephabol、Encefabol、Cerbon 6）とも呼ばれ、ビタミンB₆（ピリドキシン塩酸塩）の半合成水溶性類似体である。1961年にMerck研究所によって、2つのビタミンB₆化合物（ピリドキシン）をジスルフィド結合させることによって製造された。1970年代から、認知障害、関節リウマチ、小児の学習障害の薬物として、いくつかの国で処方薬やOTC薬物となっている。1990年代初頭からアメリカでは向精神薬栄養補助食品として販売されている。

利用可能性

オーストリア、ドイツ、フランス、イタリア、ポルトガル、ギリシャなどヨーロッパ各国で「認知症症候群における慢性的に低下した脳機能の対症療法」および「頭蓋大脳外傷の後遺症の支持療法」として承認されている。フランスでは、臨床試験の結果に基づいて疾患修飾薬として関節リウマチにも承認されている。多くの国で市販されており、インターネット上では「記憶障害」の薬として広く宣伝されている。

副作用

副作用には吐き気、頭痛、まれにアレルギー反応（軽度の皮膚反応）などがある。 2004年に行われた6件の症例報告の調査では、ピリチノールと特定の疾患に対するいくつかの薬物を服用している場合、重篤な胆汁うっ滞性肝炎との関連が示唆されている。

その他のまれな副作用：急性膵炎、光アレルギー性発疹。

こちらも参照

外部リンク

Media related to Pyritinol at Wikimedia Commons

@@ Line 62: / Line 62: @@
 * [[Sulbutiamine/ja]]
-<div lang="en" dir="ltr" class="mw-content-ltr">
+==外部リンク==
-==External links==
+*{{Commons category-inline|Pyritinol}}
-*{{Commons category-inline}}
-</div>
-<div lang="en" dir="ltr" class="mw-content-ltr">
+{{Stimulants/ja}}{{Vitamins/ja}}
-{{Stimulants}}{{Vitamins}}
-</div>
-<div lang="en" dir="ltr" class="mw-content-ltr">
-{{二次利用|date=23 March 2024}}
 [[Category:Antioxidants]]
 [[Category:Nootropics]]
@@ Line 79: / Line 73: @@
 [[Category:Phenols]]
 [[Category:Primary alcohols]]
-</div>

v t e Stimulant/ja
Adamantane/ja	Adapromine/ja Amantadine/ja Bromantane/ja Memantine/ja Rimantadine/ja
アデノシン拮抗薬	8-Chlorotheophylline/ja 8-シクロペンチルテオフィリン 8-Phenyltheophylline/ja Aminophylline/ja Caffeine/ja CGS-15943/ja Dimethazan/ja Istradefylline/ja Paraxanthine/ja SCH-58261/ja Theobromine/ja Theophylline/ja
アルキルアミン	Cyclopentamine/ja Cypenamine/ja Cyprodenate/ja Heptaminol/ja Isometheptene/ja Levopropylhexedrine/ja メチルヘキサンアミン Octodrine/ja Propylhexedrine/ja Tuaminoheptane/ja
Ampakine/ja	CX-516/ja CX-546/ja CX-614/ja CX-691 CX-717 IDRA-21/ja LY-404,187/ja LY-503,430/ja Nooglutyl/ja Org 26576/ja PEPA S-18986/ja Sunifiram/ja Unifiram/ja
Arylcyclohexylamine/ja	Benocyclidine/ja Dieticyclidine/ja Esketamine/ja Eticyclidine/ja Gacyclidine/ja Ketamine/ja Phencyclamine/ja Phencyclidine/ja Rolicyclidine/ja Tenocyclidine/ja Tiletamine/ja
Benzazepine/ja	6-Br-APB/ja SKF-77434/ja SKF-81297/ja SKF-82958/ja
カティノン	3-Fluoromethcathinone/ja 3,4-DMMC 4-BMC 4-CMC 4-Methylbuphedrone/ja 4-Methylcathinone/ja 4-MEAP 4-Methylpentedrone/ja Amfepramone/ja Benzedrone/ja Buphedrone/ja Bupropion/ja Butylone/ja Cathinone/ja Dimethylcathinone/ja Ethcathinone/ja Ethylone/ja Flephedrone/ja Hexedrone/ja Isoethcathinone/ja Mephedrone/ja Methcathinone/ja Methedrone/ja Methylenedioxycathinone/ja Methylone/ja Mexedrone/ja N-Ethylbuphedrone/ja N-Ethylhexedrone/ja Pentedrone/ja Pentylone/ja Phthalimidopropiophenone/ja
コリン作動薬	A-84,543/ja A-366,833/ja ABT-202/ja ABT-418/ja AR-R17779/ja Altinicline/ja Anabasine/ja Arecoline/ja Bradanicline/ja Cotinine/ja Cytisine/ja Dianicline/ja Epibatidine/ja Epiboxidine/ja GTS-21/ja Ispronicline/ja Nicotine/ja PHA-543,613/ja PNU-120,596/ja PNU-282,987/ja Pozanicline/ja Rivanicline/ja Sazetidine A/ja SIB-1553A/ja SSR-180,711/ja TC-1698/ja TC-1827/ja TC-2216/ja Tebanicline/ja UB-165/ja Varenicline/ja WAY-317,538/ja
痙攣薬	Anatoxin-a/ja Bicuculline/ja DMCM/ja Flurothyl/ja Gabazine/ja ペンテトラゾール Picrotoxin/ja Strychnine/ja Thujone/ja
Eugeroic/ja	Adrafinil/ja Armodafinil/ja CRL-40,940/ja CRL-40,941/ja Fluorenol/ja Modafinil/ja
Oxazoline/ja	4-Methylaminorex/ja Aminorex/ja Clominorex/ja Cyclazodone/ja Fenozolone/ja Fluminorex/ja Pemoline/ja Thozalinone/ja
フェネチルアミン	1-(4-メチルフェニル)-2-アミノブタン 1-Methylamino-1-(3,4-methylenedioxyphenyl)propane/ja 2-Fluoroamphetamine/ja 2-Fluoromethamphetamine/ja 2-OH-PEA 2-Phenyl-3-aminobutane/ja 2,3-MDA 3-Fluoroamphetamine/ja 3-Fluoroethamphetamine/ja 3-Methoxyamphetamine/ja 3-Methylamphetamine/ja 4-フルオロアンフェタミン 4-フルオロメタンフェタミン 4-MA 4-MMA 4-MTA 6-FNE AL-1095/ja Alfetamine/ja a-エチルフェネチルアミン Amfecloral/ja Amfepentorex/ja Amidephrine/ja 2-Amino-1,2-dihydronaphthalene/ja 2-Aminoindane/ja 5-(2-Aminopropyl)indole/ja 2-Aminotetralin/ja Acridorex/ja Amphetamine/ja (Dextroamphetamine/ja, Levoamphetamine/ja) Amphetaminil/ja Arbutamine/ja β-Methylphenethylamine/ja β-Phenylmethamphetamine/ja Benfluorex/ja Benzphetamine/ja BDB BOH 3-Benzhydrylmorpholine/ja BPAP Camfetamine/ja Cathine/ja Chlorphentermine/ja Cilobamine/ja Cinnamedrine/ja Clenbuterol/ja Clobenzorex/ja Cloforex/ja Clortermine/ja Cypenamine/ja D-デプレニル Denopamine/ja Dimethoxyamphetamine/ja Dimethylamphetamine/ja Dobutamine/ja DOPA (デキストロドパ, レボドパ) Dopamine/ja Dopexamine/ja ドロキシドパ EBDB Ephedrine/ja Epinephrine/ja Epinine/ja Etafedrine/ja Ethylnorepinephrine/ja Etilamfetamine/ja Etilefrine/ja Famprofazone/ja Fencamfamin/ja Fencamine/ja Fenethylline/ja Fenfluramine/ja (Dexfenfluramine/ja, Levofenfluramine/ja) Fenproporex/ja Feprosidnine/ja Fludorex/ja Formetorex/ja Furfenorex/ja Gepefrine/ja Hexapradol/ja HMMA Hordenine/ja 4-Hydroxyamphetamine/ja 5-ヨード-2-アミノインダン Ibopamine/ja インダニルアンフェタミン Iofetamine/ja Isoetarine/ja Isoprenaline/ja L-デプレニル（セレギリン） Lefetamine/ja Lisdexamfetamine/ja Lophophine/ja MBDB MDA (テナムフェタミン) MDBU MDEA MDMA (ミドマフェタミン) MDMPEA MDOH MDPR MDPEA Mefenorex/ja Mephentermine/ja Metanephrine/ja Metaraminol/ja Mesocarb/ja Methamphetamine/ja (デキストロメタンフェタミン, Levomethamphetamine/ja) Methoxamine/ja Methoxyphenamine/ja MMA Methoxyphenamine/ja MMDA MMDMA/ja MMMA Morforex/ja N,alpha-Diethylphenylethylamine/ja N,N-Dimethylphenethylamine/ja ナフチルアンフェタミン Nisoxetine/ja Norepinephrine/ja Norfenefrine/ja Norfenfluramine/ja Normetanephrine/ja L-ノルプソイドエフェドリン Octopamine/ja Orciprenaline/ja Ortetamine/ja Oxifentorex/ja Oxilofrine/ja PBA PCA PCMA PHA Pentorex/ja Phenatine/ja Phenpromethamine/ja Phentermine/ja Phenylalanine/ja Phenylephrine/ja Phenylpropanolamine/ja Pholedrine/ja PIA PMA PMEA PMMA PPAP Prenylamine/ja Propylamphetamine/ja Pseudoephedrine/ja Ropinirole/ja Salbutamol/ja (Levosalbutamol/ja) Sibutramine/ja Solriamfetol/ja Synephrine/ja Theodrenaline/ja Tiflorex/ja Tranylcypromine/ja Tyramine/ja Tyrosine/ja Xylopropamine/ja Zylofuramine/ja
フェニルモルフォリン	3-Fluorophenmetrazine/ja Fenbutrazate/ja Fenmetramide/ja G-130/ja Manifaxine/ja Morazone/ja Morforex/ja Oxaflozane/ja PD-128,907/ja Phendimetrazine/ja Phenmetrazine/ja 2-Phenyl-3,6-dimethylmorpholine/ja Pseudophenmetrazine/ja Radafaxine/ja
Piperazine/ja	2C-B-BZP/ja 3C-PEP BZP CM156/ja DBL-583/ja GBR-12783/ja GBR-12935/ja GBR-13069/ja GBR-13098/ja GBR-13119/ja MeOPP MBZP oMPP Vanoxerine/ja
Piperidine/ja	1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine/ja 2-Benzylpiperidine/ja 2-Methyl-3-phenylpiperidine/ja 3,4-Dichloromethylphenidate/ja 4-Benzylpiperidine/ja 4-Fluoromethylphenidate/ja 4-Methylmethylphenidate/ja Desoxypipradrol/ja Difemetorex/ja Diphenylpyraline/ja Ethylnaphthidate/ja Ethylphenidate/ja Methylnaphthidate/ja Isopropylphenidate/ja JZ-IV-10/ja Methylphenidate/ja (Dexmethylphenidate/ja) ノカインファセトペラン Pipradrol/ja Propylphenidate/ja SCH-5472/ja
Pyrrolidine/ja	2-Diphenylmethylpyrrolidine/ja 4-Cl-PVP 5-DBFPV/ja α-PPP α-PBP α-PCYP/ja α-PHiP/ja α-PHP α-PHPP α-PVP α-PVT Diphenylprolinol/ja DMPVP FPOP FPVP MDPPP MDPBP MPBP MPHP MPPP MOPVP MOPPP Indapyrophenidone/ja MDPV Naphyrone/ja PEP Picilorex/ja Prolintane/ja Pyrovalerone/ja
Racetam/ja	Oxiracetam/ja Phenylpiracetam/ja Phenylpiracetam hydrazide/ja
Tropane/ja	4-fluorotropacocaine/ja 4'-Fluorococaine/ja Altropane (IACFT) Brasofensine/ja CFT (WIN 35,428) β-CIT (RTI-55) Cocaethylene/ja Cocaine/ja ジクロロパン (RTI-111) Difluoropine/ja FE-β-CPPIT/ja FP-β-CPPIT イオフルパン (¹²³I) Norcocaine/ja PIT PTT RTI-31/ja RTI-32/ja RTI-51/ja RTI-112/ja RTI-113/ja RTI-120/ja RTI-121 (IPCIT) RTI-126/ja RTI-150/ja RTI-177/ja RTI-229/ja RTI-336 RTI-354/ja RTI-371/ja RTI-386/ja Salicylmethylecgonine/ja Tesofensine/ja トロパリル (β-CPT, WIN 35,065-2) Tropoxane/ja WF-23 WF-33
トリプタミン	4-HO-αMT/ja 4-Methyl-αET/ja 4-Methyl-αMT/ja 5-Chloro-αMT/ja 5-Fluoro-αMT/ja 5-MeO-αET/ja 5-MeO-αMT/ja 5-MeO-DIPT 6-Fluoro-αMT/ja 7-Methyl-αET/ja αET αMT
その他	2-MDP/ja 3,3-Diphenylcyclobutanamine/ja Amfonelic acid/ja Amineptine/ja Amiphenazole/ja Atipamezole/ja Atomoxetine/ja Bemegride/ja Benzydamine/ja BTQ BTS 74,398/ja Centanafadine/ja Ciclazindol/ja Clofenciclan/ja Cropropamide/ja Crotetamide/ja D-161/ja Desipramine/ja Diclofensine/ja Dimethocaine/ja Efaroxan/ja Etamivan/ja Fenisorex/ja Fenpentadiol/ja Gamfexine/ja Gilutensin/ja GSK1360707F/ja GYKI-52895/ja Hexacyclonate/ja Idazoxan/ja Indanorex/ja Indatraline/ja JNJ-7925476/ja Lazabemide/ja Leptacline/ja Lomevactone/ja LR-5182/ja Mazindol/ja Meclofenoxate/ja Medifoxamine/ja Mefexamide/ja Methamnetamine/ja Methastyridone/ja Methiopropamine/ja Naphthylaminopropane/ja Nefopam/ja Nikethamide/ja Nomifensine/ja O-2172/ja Oxaprotiline/ja PNU-99,194/ja PRC200-SS Rasagiline/ja Rauwolscine/ja Rubidium chloride/ja Setazindol/ja Tametraline/ja Tandamine/ja Thiopropamine/ja Thiothinone/ja Trazium/ja UH-232/ja Yohimbine/ja
ATCコード: N06B

Pyritinol/ja: Difference between revisions

Latest revision as of 16:10, 4 April 2024

Contents

利用可能性

副作用

こちらも参照

外部リンク

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Clinical data

ATC code	N06BX02 (WHO)
Pharmacokinetic data
Elimination half-life	2.5 hours
Identifiers
IUPAC name 5,5'-[dithiobis(methylene)]bis[4-(hydroxymethyl)-2-methylpyridin-3-ol]
CAS Number	1098-97-1^N
PubChem CID	14190
ChemSpider	13561^Y
UNII	AK5Q5FZH2R
KEGG	D02160^Y
ChEMBL	ChEMBL488093^Y
Chemical and physical data
Formula	C₁₆H₂₀N₂O₄S₂
Molar mass	368.47 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Oc1c(c(cnc1C)CSSCc2c(c(O)c(nc2)C)CO)CO
InChI InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3^Y Key:SIXLXDIJGIWWFU-UHFFFAOYSA-N^Y
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Pyritinol/ja: Difference between revisions

Latest revision as of 16:10, 4 April 2024

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