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Combined display of all available logs of Azupedia. You can narrow down the view by selecting a log type, the username (case-sensitive), or the affected page (also case-sensitive).
- 12:24, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/9/ja (Created page with "==DPP-4の特徴== {{Anchor|DPP-4 characteristics}} DPP-4はプロテアーゼであるため、阻害剤がペプチドの性質を持つことは予想外ではなく、このテーマは現代の研究にも受け継がれている。")
- 12:23, 12 March 2024 Fire talk contribs created page Translations:Metformin/55/ja (Created page with "抗糖尿病薬のビグアナイドクラスは、休薬中のフェンフォルミンとブフォルミンも含み、数世紀にわたって民間療法で使用されてきたフレンチライラックまたはヤギのルー（''Galega officinalis''）に由来する。''G.officinalis''自体にはこれらの医薬品は含まれていないが、Galegine/ja|イソアミレングア...")
- 12:22, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/68/ja (Created page with "シタグリプチンおよびビルダグリプチンの薬物動態学的特性は、年齢、性別、またはBMIの影響を受けないようである。臨床研究では、シタグリプチンおよびビルダグリプチンには、2型糖尿病の治療後に起こりがちな副作用、例えばweight g...")
- 12:20, 12 March 2024 Fire talk contribs created page Translations:Metformin/54/ja (Created page with "== 歴史 == {{Anchor|Hisotry}} right|thumb|''ガレガ・オフィシナリス''はガレギンの天然源である。")
- 12:19, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/67/ja (Created page with "{| class="wikitable" align="center" |+ シタグリプチンとビルダグリプチンの比較薬理学 |- ! 薬剤 !!吸収 !! 生物学的利用能 (%) !!IC<sub>50</sub> (nM) !!平均分布容積 (L) !!タンパク質結合 (%) !!半減期 (時間,100 mg ドーズ) !!代謝 !!排泄 |- | '''シタグリプチン''' ||急速に吸収され、1～4時間で濃度がピークに達する ||align="center"|87 ||align="center"|18 ||align="center"|198 ||align="center"|...")
- 12:15, 12 March 2024 Fire talk contribs created page Translations:Metformin/53/ja (Created page with "===誘導体=== IM156としても知られる新規誘導体HL156Aは、医療用新薬の可能性がある。")
- 12:15, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/66/ja (Created page with "==薬理学== {{Anchor|Pharmacology}}")
- 12:14, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/69/ja (Created page with "==こちらも参照== * ジペプチジルペプチダーゼ4 * Dipeptidyl peptidase-4 inhibitors/ja * Linagliptin/ja * Vildagliptin/ja * シタグリプチン * Saxagliptin/ja * Berberine/ja * teneligliptin/ja * gosogliptin/ja")
- 12:14, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/70/ja (Created page with "{{Drug design/ja}}")
- 12:14, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/71/ja (Created page with "{{DEFAULTSORT:Development Of Dipeptidyl Peptidase-4 Inhibitors}} Category:Dipeptidyl peptidase-4 inhibitors Dipeptidyl peptidase-4 inhibitors")
- 12:14, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/8/ja (Created page with "DPP-4は、GLP-1やGIPなどのペプチドから、2位にプロリンやアラニンを持つ2つのアミノ酸を選択的に切断する（''図2''）。DPP-4が効果を発揮する活性部位には、Asp-His-Serの3つのアミノ酸が特徴的に配置されている。 GPL-1やGIPの生物活性にはアラニンとpro...")
- 12:12, 12 March 2024 Fire talk contribs created page Translations:Metformin/52/ja (Created page with "1975年のアロン特許および''医薬品製造百科事典''に記載された手順によると、等モル量のジメチルアミンと2-シアノグアニジンを冷却しながらトルエンに溶解して濃縮溶液とし、等モル量の塩化水素をゆっくりと加える。混合物はそれ自体で沸騰し始め、冷却後、メトホル...")
- 12:07, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/7/ja (Created page with "===DPP-4の分布と機能=== thumb|220px|left|'''図2:'''DPP-4は、GLP-1などのペプチドのN末端から2つのアミノ酸を切断する。 DPP-4は身体のほとんど全ての臓器の内皮の細胞膜に付着している。DPP-4を強く発現している組織には、外分泌膵臓、汗腺、salivary gland/ja|唾...")
- 12:01, 12 March 2024 Fire talk contribs created page Translations:Metformin/51/ja (Created page with "center|300px")
- 12:01, 12 March 2024 Fire talk contribs created page Translations:Metformin/50/ja (Created page with "== 化学 == {{Anchor|Chemistry}} メトホルミン塩酸塩（1,1-ジメチルビグアニド塩酸塩）は、水に自由に溶け、エタノールにわずかに溶けるが、アセトン、エーテル、クロロホルムにはほとんど溶けない。メトホルミンのpK<sub>a</sub>は12.4である。1922年に記載されたメトホルミンの通常の合成は、ジメチルアミンhydrochloride/ja|塩...")
- 11:59, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/6/ja (Created page with "GLP-1とGIPは、酵素DPP-4によって触媒される非常に速い不活性化により、血漿半減期が極めて短い。DPP-4である。DPP-4を阻害すると、これらの不活性化が遅くなり、作用が増強され、血漿中のグルコース濃度が低下するので、2型糖尿病の治療に有用である。(図1）。")
- 11:58, 12 March 2024 Fire talk contribs created page Translations:Metformin/49/ja (Created page with "ヒトにおけるメトホルミンの肝濃度は、経口投与における門脈吸収と肝臓による初回通過取り込みにより、血漿中濃度の2～3倍高い可能性があることを示す証拠もある。")
- 11:58, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/5/ja (Created page with "==DPP-4のメカニズム=== thumb|350px '''図1:''''食事中に、インクレチンであるグルカゴン様ペプチド1（GLP-1）とグルコース依存性胃抑制ポリペプチド（GIP）が小腸から血液中に放出される。これらのホルモンはグルコース依存的に...")
- 11:56, 12 March 2024 Fire talk contribs created page Translations:Metformin/48/ja (Created page with "メトホルミンは代謝されない。メトホルミンは尿細管分泌によって体外に排出され、尿中に未変化のまま排泄される；単回経口投与後24時間以内の血漿中では検出されない。血漿中の平均脱離半減期は6.2時間である。メトホルミンは赤血球に分布し（蓄...")
- 11:54, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/4/ja (Created page with "1995年、Novartisのエドウィン・B・ヴィルハウアーは、DPP-4がN-メチルグリシンをN-末端のアミノ酸として同定するという事実に基づいて、N-置換グリシニル-シアノピロリジンの探索を開始した。この新しいシアノピロリジン群は、その後の数年間、非常に人気のある研究分野となった。バソペプチダーゼ阻害はインスリン分泌を...")
- 11:53, 12 March 2024 Fire talk contribs created page Translations:Metformin/47/ja (Created page with "メトホルミンの酸解離定数（pK<sub>a</sub>）は2.8と11.5であるため、生理的pH値では非常に大部分が親水性の陽イオン種として存在する。メトホルミンのpK<sub>a</sub>値は、血中非イオン化率0.01％未満の他のほとんどの塩基性医薬品よりも強い塩基となる。さらに、非イオン化種の脂溶性は、-1.43という低いlogP値（オクタノールと水の間の非イ...")
- 11:52, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/3/ja (Created page with "1994年、ゼリア新薬の研究者はニトリルを官能基とするシアノピロリジンを発表した。これは触媒であるセリンとイミデートを形成すると想定されていた。同時に、ニトリル基を持たない他のDPP-4阻害剤も発表されたが、それらは他のセリンと相互作用するモチーフ、例えばboronic a...")
- 11:49, 12 March 2024 Fire talk contribs created page Translations:Metformin/46/ja (Created page with "=== 薬物動態 === メトホルミンの経口生物学的利用能は、空腹条件下で50～60％であり、ゆっくりと吸収される。血漿中濃度のピーク（C<sub>max</sub>）は、メトホルミンの即時放出型製剤では服用後1～3時間以内に、徐放型製剤では4～8時間以内に到達する。メトホルミンの血漿タンパク質結合は、非常に高い...")
- 11:47, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/2/ja (Created page with "==歴史== {{Anchor|History}} 1967年に発見されて以来、セリンプロテアーゼDPP-4は人気のある研究対象であった。DPP-4の阻害剤は、酵素の機能的意義を解明するためのツールとして長い間求められてきた。最初の阻害剤は1980年代後半から1990年代にかけて特徴づけられた。それぞれの阻害剤は、その後の研究のための初期のstructure acti...")
- 11:42, 12 March 2024 Fire talk contribs created page Translations:Metformin/45/ja (Created page with "GLUT4とAMPKに作用することから、メトホルミンは運動模倣薬と呼ばれている。")
- 10:34, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/1/ja (Created page with "ジペプチジルペプチダーゼ-4阻害薬（DPP-4阻害薬）は、酵素ジペプチジルペプチダーゼ-4 (DPP-4)を阻害する酵素阻害薬である。これらは2型糖尿病の治療に用いられる。DPP-4酵素の阻害は、インスリン分泌と血糖コントロール...")
- 10:33, 12 March 2024 Fire talk contribs created page Discovery and development of dipeptidyl peptidase-4 inhibitors/ja (Created page with "ジペプチジルペプチダーゼ-4阻害剤の発見と開発") Tags: Mobile edit Mobile web edit
- 10:31, 12 March 2024 FuzzyBot talk contribs created page Discovery and development of dipeptidyl peptidase-4 inhibitors/en (Updating to match new version of source page) Tags: Mobile edit Mobile web edit
- 10:31, 12 March 2024 Fire talk contribs created page Translations:Metformin/44/ja (Created page with "メトホルミンはまた、腸内細菌によるアグマチン産生を増加させる効果など、腸内細菌叢にも大きな影響を及ぼすが、他の機序と比較してこの機序の相対的重要性は不明である。")
- 10:31, 12 March 2024 Fire talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/Page display title/ja (Created page with "ジペプチジルペプチダーゼ-4阻害剤の発見と開発")
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/71/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/70/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/69/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/68/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/67/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/66/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/65/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/64/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/63/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/62/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/61/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/60/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/59/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/58/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/57/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/56/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/55/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/54/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/53/en (Importing a new version from external source)
- 10:30, 12 March 2024 FuzzyBot talk contribs created page Translations:Discovery and development of dipeptidyl peptidase-4 inhibitors/52/en (Importing a new version from external source)
