Calcium channel blocker: Difference between revisions

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==Mechanism of action==

[[File:Calciumkanal Förstermann.jpg|thumb|right|250px|A calcium channel embedded in a cell membrane.]]

In the body's tissues, the concentration of calcium ions ({{chem|Ca|2+}}) outside cells is normally about 10,000-fold higher than the concentration inside cells. Embedded in the [[cell membrane|membrane]] of some cells are [[calcium channel]]s. When these cells receive a certain signal, the channels open, letting calcium rush into the cell. The resulting increase in intracellular calcium has different effects in different types of cells. Calcium channel blockers prevent or reduce the opening of these channels and thereby reduce these effects.~~{{cn|date=July 2022}}~~

In the body's tissues, the concentration of calcium ions ({{chem|Ca|2+}}) outside cells is normally about 10,000-fold higher than the concentration inside cells. Embedded in the [[cell membrane|membrane]] of some cells are [[calcium channel]]s. When these cells receive a certain signal, the channels open, letting calcium rush into the cell. The resulting increase in intracellular calcium has different effects in different types of cells. Calcium channel blockers prevent or reduce the opening of these channels and thereby reduce these effects.

Several types of calcium channels occur, with a number of classes of blockers, but almost all of them preferentially or exclusively block the [[L-type calcium channel|L-type]] voltage-gated calcium channel.<ref name=mech>{{cite journal|author=Yousef|title=The mechanism of action of calcium channel blockers in the treatment of diabetic nephropathy|journal=Int J Diabetes & Metabolism|year=2005|volume=13|issue=2|pages=76–82|url=http://ijod.uaeu.ac.ae/iss_1302/b.pdf|display-authors=etal|access-date=2013-06-29|archive-url=https://web.archive.org/web/20151010061053/http://ijod.uaeu.ac.ae/iss_1302/b.pdf|archive-date=2015-10-10|doi=10.1159/000497574}}</ref>

@@ Line 108: / Line 108: @@
 ==Mechanism of action==
 [[File:Calciumkanal Förstermann.jpg|thumb|right|250px|A calcium channel embedded in a cell membrane.]]
-In the body's tissues, the concentration of calcium ions ({{chem|Ca|2+}}) outside cells is normally about 10,000-fold higher than the concentration inside cells. Embedded in the [[cell membrane|membrane]] of some cells are [[calcium channel]]s. When these cells receive a certain signal, the channels open, letting calcium rush into the cell. The resulting increase in intracellular calcium has different effects in different types of cells. Calcium channel blockers prevent or reduce the opening of these channels and thereby reduce these effects.{{cn|date=July 2022}}
+In the body's tissues, the concentration of calcium ions ({{chem|Ca|2+}}) outside cells is normally about 10,000-fold higher than the concentration inside cells. Embedded in the [[cell membrane|membrane]] of some cells are [[calcium channel]]s. When these cells receive a certain signal, the channels open, letting calcium rush into the cell. The resulting increase in intracellular calcium has different effects in different types of cells. Calcium channel blockers prevent or reduce the opening of these channels and thereby reduce these effects.
 Several types of calcium channels occur, with a number of classes of blockers, but almost all of them preferentially or exclusively block the [[L-type calcium channel|L-type]] voltage-gated calcium channel.<ref name=mech>{{cite journal|author=Yousef|title=The mechanism of action of calcium channel blockers in the treatment of diabetic nephropathy|journal=Int J Diabetes & Metabolism|year=2005|volume=13|issue=2|pages=76–82|url=http://ijod.uaeu.ac.ae/iss_1302/b.pdf|display-authors=etal|access-date=2013-06-29|archive-url=https://web.archive.org/web/20151010061053/http://ijod.uaeu.ac.ae/iss_1302/b.pdf|archive-date=2015-10-10|doi=10.1159/000497574}}</ref>