Main public logs

Combined display of all available logs of Azupedia. You can narrow down the view by selecting a log type, the username (case-sensitive), or the affected page (also case-sensitive).

• 20:12, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/16/ja (Created page with "中性エンドペプチダーゼ24.11 (NEP 24.11)は、膜結合型の亜鉛金属ペプチダーゼで、いくつかの組織に広く発現しているが、特に腎臓に高濃度で存在し、GLP-1の迅速な分解に関与していることも確認されている。主に芳香族アミノ酸や疎水性アミノ酸のN末端側のペ...")
• 20:09, 11 March 2024 Fire talk contribs created page Translations:Metformin/13/ja (Created page with "==== 有効性 ====")
• 20:09, 11 March 2024 Fire talk contribs created page Translations:Metformin/12/ja (Created page with "=== 2型糖尿病=== 米国糖尿病学会と米国内科学会はともに、メトホルミンを2型糖尿病治療の第一選択薬として推奨している。メトホルミンはレパグリニドと同程度に有効であり、2型糖尿病に対する他のすべての経口薬物よりも有効である。")
• 20:08, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/15/ja (Created page with "分泌されたGLP-1は、タンパク質分解酵素ジペプチジルペプチダーゼ-4（DPP-4）の触媒活性に極めて弱い。具体的には、DPP-4はAla⁸-Glu⁹間のペプチド結合を切断し、GLP-1 (9-36)アミドを生成する。DPP-4は様々な組織や細胞で広く発現しており、膜に固定さ...")
• 20:03, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/14/ja (Created page with "==劣化== {{Anchor|Degradation}}")
• 20:02, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/13/ja (Created page with "糖は様々なシグナル伝達経路と関連しており、L細胞膜の脱分極を引き起こし、細胞質濃度の上昇を引き起こす。Ca²⁺の上昇を引き起こし、GLP-1の分泌を誘導する。脂肪酸は細胞内のCa<up>2+</up>の動員に関連付けられている。Ca²⁺貯蔵とそれに続くCa<sup>2+...")
• 20:01, 11 March 2024 Fire talk contribs created page Translations:Metformin/11/ja (Created page with "== 医療用途 == {{Anchor|Medical uses}} メトホルミンは、2型糖尿病患者の血糖を低下させるために使用される。また、多嚢胞性卵巣症候群の不妊症の第二選択薬としても用いられる。")
• 20:00, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/12/ja (Created page with "生物学的に活性なGLP-1の空腹時血漿中濃度は、ヒトで0～15pmol/Lの間であり、食事の量や栄養組成にもよるが、食事を摂取すると2～3倍に増加する。脂肪酸、必須アミノ酸、食物繊維などの個々の栄養素もGLP-1の分泌を刺激することが示されている。")
• 19:59, 11 March 2024 Fire talk contribs created page Translations:Metformin/10/ja (Created page with "<!-- History, society, and culture --> メトホルミンは、1922年にEmil WernerとJames Bellによって初めて科学文献に記載された。フランスの医師ジャン・スターン（Jean Sterne）は1950年代にヒトでの研究を開始した。フランスでは1957年に、米国では1995年に医薬品として導入された。メトホルミンは世界保健機関の必須医薬品リストに掲載...")
• 19:58, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/11/ja (Created page with "GLP-1は二相性パターンで放出され、10-15分後に初期相が、続いて食事摂取後30-60分後に第二相が長く続く。L細胞の大部分は遠位回腸と結腸に存在するため、初期相は神経シグナル、腸ペプチドまたは神経伝達物質によって説明される可能性が高い。他の証拠によると、近位空腸にあるL細胞の量...")
• 19:54, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/26/ja (Created page with "== こちらも参照== * Glucagon-like peptide 1 receptor/ja * Glucagon-like peptide-2/ja * 2型糖尿病 * GLP-1受容体作動薬 : albiglutide/ja, dulaglutide/ja, exenatide/ja, liraglutide/ja, lixisenatide/ja, semaglutide/ja, tirzepatide/ja * ジペプチジルペプチダーゼ4 * Glucose-dependent insulinotropic peptide/ja")
• 19:54, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/27/ja (Created page with " ")
• 19:54, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/28/ja (Created page with "== 外部リンク == * {{UTGlucagon|glp1}} * {{MeshName|Glucagon-Like+Peptide+1}} * [http://www.genome.jp/kegg-bin/show_pathway?ko04911+K04581 Insulin release pathways]")
• 19:53, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/29/ja (Created page with "{{Proglucagon/ja}} {{Oral hypoglycemics and insulin analogs/ja}}")
• 19:53, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/30/ja (Created page with "American diabetes association:link-http://diabetes.diabetesjournals.org/content/56/1/8.full")
• 19:53, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/31/ja (Created page with "{{DEFAULTSORT:Glucagon-Like Peptide-1}} Category:Anti-diabetic drugs Category:Peptide hormones")
• 19:53, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/10/ja (Created page with "GLP-1は分泌顆粒にパッケージされ、主に回腸と結腸の遠位に位置するが、空腸と十二指腸にも存在する腸管L細胞によって肝門脈系に分泌される。L細胞は開口型の三角形の上皮細胞で、内腔や神経血管組織と直接接しており、それに応じて様々な栄養、...")
• 19:50, 11 March 2024 Fire talk contribs created page Translations:Metformin/9/ja (Created page with "<!-- Drug class and mechanism --> メトホルミンはビグアナイド系抗高血糖薬である。肝臓におけるグルコース産生を減少させ、体組織のインスリン感受性を高めることによって作用する、")
• 19:49, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/9/ja (Created page with "==分泌== {{Anchor|Secretion}}")
• 19:48, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/8/ja (Created page with "腸と脳では、プログルカゴンはPC 1/3によって触媒され、グリセンチンを生じ、さらにGRPPとオキシントモジュリン、GLP-1、介在ペプチド-2（IP-2）、グルカゴン様ペプチド-2（GLP-2）に処理される。当初、GLP-1はMGPFのN-末端に適したプログルカゴン（72-108）に対応すると考えられてい...")
• 19:45, 11 March 2024 Fire talk contribs created page Translations:Metformin/8/ja (Created page with "<!-- Adverse effects --> メトホルミンは一般的に忍容性が高い。一般的な副作用には、下痢、吐き気、腹痛などがある。メトホルミンは低血糖を引き起こすリスクが小さい。高血中乳酸値（アシドーシス）は、医薬品を過度に大量に使用したり、重度の腎障害のある人に処方...")
• 19:44, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/7/ja (Created page with "膵臓（ランゲルハンス島のα細胞）では、プログルカゴンはプロホルモン変換酵素（PC）2によって切断され、グリセンチン関連膵ペプチド（GRPP）、グルカゴン、介在ペプチド-1（IP-1）、主要プログルカゴンフラグメント（MPGF）を産生する。")
• 19:43, 11 March 2024 Fire talk contribs created page Translations:Metformin/7/ja (Created page with "<!-- Definition and medical uses --> '''メトホルミン'''（'''Metformin'''）は、'''グルコファージ（'''Glucophage'''）などの商品名で販売されており、特に太りすぎの2型糖尿病の治療のための主要な第一選択医薬品である。また、多嚢胞性卵巣症候群の治療にも用いられる。antipsychotic/ja|...")
• 19:40, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/6/ja (Created page with "プログルカゴン遺伝子は、膵臓（ランゲルハンス島のα細胞）、腸（腸内分泌L細胞）および脳（尾側脳幹および視床下部）を含むいくつかの臓器で発現している。膵プログルカゴン遺伝子の発現は、空腹時および低血糖誘導時に促進され、インスリンによって抑制される。...")
• 19:39, 11 March 2024 Fire talk contribs created page Translations:Metformin/103/ja (Created page with " ")
• 19:38, 11 March 2024 Fire talk contribs created page Translations:Metformin/104/ja (Created page with "== さらに読む == {{refbegin}} * {{cite journal | vauthors = Markowicz-Piasecka M, Huttunen KM, Mateusiak L, Mikiciuk-Olasik E, Sikora J | title = Is Metformin a Perfect Drug? Updates in Pharmacokinetics and Pharmacodynamics | journal = Current Pharmaceutical Design | volume = 23 | issue = 17 | pages = 2532–2550 | date = 2017 | pmid = 27908266 | doi = 10.2174/1381612822666161201152941 }} * {{cite journal | vauthors = McCreight LJ, Bailey CJ, Pearson ER | title = Me...")
• 19:38, 11 March 2024 Fire talk contribs created page Translations:Metformin/105/ja (Created page with "== 外部リンク == {{Commons category|Metformin}} * {{cite web | title=Nitrosamine impurities in medications: Guidance | website=Health Canada | date=4 April 2022 | url=https://www.canada.ca/en/health-canada/services/drugs-health-products/compliance-enforcement/information-health-product/drugs/nitrosamine-impurities/medications-guidance.html }}")
• 19:38, 11 March 2024 Fire talk contribs created page Translations:Metformin/106/ja (Created page with "{{Merck Serono|state=autocollapse}} {{Oral hypoglycemics and insulin analogs|state=collapsed}} {{Portal bar | Medicine}}")
• 19:38, 11 March 2024 Fire talk contribs created page Translations:Metformin/107/ja (Created page with "Category:Biguanides Category:Drugs developed by Boehringer Ingelheim Category:Drugs with unknown mechanisms of action Category:Guanidines Category:Drugs developed by Merck Category:Wikipedia medicine articles ready to translate Category:World Health Organization essential medicines Category:Orphan drugs Category:Exercise mimetics")
• 19:38, 11 March 2024 Fire talk contribs created page Translations:Metformin/6/ja (Created page with "<!-- Chemical and physical data --> | IUPAC_name = ''N'',''N''-Dimethylimidodicarbonimidic diamide | C = 4 | H = 11 | N = 5 | SMILES = CN(C)C(=N)N=C(N)N | StdInChI = 1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8) | StdInChI_comment = | StdInChIKey = XZWYZXLIPXDOLR-UHFFFAOYSA-N | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | density = 1.3±0.1 | density_notes = | melting_point = | melting_high...")
• 19:37, 11 March 2024 Fire talk contribs created page Translations:Metformin/5/ja (Created page with "<!-- Identifiers --> | index2_label = as HCl | CAS_number = 657-24-9 | CAS_number2 = 1115-70-4 | PubChem = 4091 | IUPHAR_ligand = 4779 | DrugBank = DB00331 | ChemSpiderID = 3949 | UNII = 9100L32L2N | UNII2 = 786Z46389E | KEGG = D04966 | KEGG2 = C07151 | ChEBI = 6801 | ChEBI2 = 6802 | ChEMBL = 1431 | NIAID_ChemDB = | PDB_lig...")
• 19:37, 11 March 2024 Fire talk contribs created page Translations:Metformin/4/ja (Created page with "<!-- Pharmacokinetic data --> | bioavailability = 50–60% | protein_bound = Minimal | metabolism = 肝臓ではない | metabolites = | onset = | elimination_half-life = 4–8.7 時間 | duration_of_action = | excretion = 尿中 (90%)")
• 19:37, 11 March 2024 Fire talk contribs created page Translations:Metformin/3/ja (Created page with "<!-- Legal status --> | legal_AU = S4 | legal_AU_comment = | legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F--> | legal_BR_comment = | legal_CA = Rx-only | legal_CA_comment = | legal_DE = <!-- Anlage I, II, III or Unscheduled--> | legal_DE_comment = | legal_NZ = <!-- Class A, B, C --> | legal_NZ_comment = | legal_UK = POM | legal_UK_comment = | legal_US = Rx-onl...")
• 19:37, 11 March 2024 Fire talk contribs created page Translations:Metformin/2/ja (Created page with "<!-- Clinical data --> | pronounce = {{IPAc-en|m|ɛ|t|ˈ|f|ɔːr|m|ᵻ|n}}, {{respell|met|FOR|min}} | tradename = フォルタメット, グルコファージ, グルメッツァ, その他 | Drugs.com = {{drugs.com|monograph|metformin-hydrochloride}} | MedlinePlus = a696005 | DailyMedID = Metformin | pregnancy_AU = C | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = Oral admi...")
• 19:36, 11 March 2024 Fire talk contribs created page Metformin/ja (Created page with "メトホルミン")
• 19:35, 11 March 2024 Fire talk contribs created page Translations:Metformin/1/ja (Created page with "{{Infobox drug | image = Metformin.svg | width = | alt = | image2 = Metformin-from-xtal-3D-balls.png | width2 = | alt2 = | caption =")
• 19:35, 11 March 2024 Fire talk contribs created page Translations:Metformin/Page display title/ja (Created page with "メトホルミン")
• 19:35, 11 March 2024 Fire talk contribs marked Metformin for translation
• 19:35, 11 March 2024 Fire talk contribs limited languages for translatable page Metformin to Japanese
• 19:33, 11 March 2024 Fire talk contribs created page Category:Exercise mimetics (Created page with "mimetics Category:Drugs {{cat main|Exercise mimetic}}")
• 19:33, 11 March 2024 Fire talk contribs created page Category:Orphan drugs (Created page with "{{Commons cat|Orphan drugs}} {{Cat main|Orphan drug}} Lists of all drugs that have received orphan status in the United States and Europe are available from the U.S. Food and Drug Administration and the European Commission, respectively: *[http://www.fda.gov/orphan/designat/list.htm FDA List of Orphan Designations and Approvals] *[http://ec.europa.eu/enterprise/pharmaceuticals/register/orphreg.htm European Commission Register of designated Orphan Medicinal Produ...")
• 19:32, 11 March 2024 Fire talk contribs created page Category:Drugs developed by Merck (Created page with "{{Cat main|Merck KGaA}} Category:Brands by company Category:Drug brand names Category:Health care brands Brands")
• 19:32, 11 March 2024 Fire talk contribs created page Category:Guanidines (Created page with "thumb|right|150px|The general structure of a guanidine {{Cat main|Guanidine}} {{Commons cat|Guanidines}} Category:Amidines")
• 19:32, 11 March 2024 Fire talk contribs created page Category:Drugs with unknown mechanisms of action (Created page with "This is a category for drugs in which the specific mechanism of action relevant to therapeutic effects is unknown or unclear. Category:Drugs by mechanism of action")
• 19:31, 11 March 2024 Fire talk contribs created page Category:Drugs developed by Boehringer Ingelheim (Created page with "Category:Boehringer Ingelheim")
• 19:31, 11 March 2024 Fire talk contribs created page Category:Biguanides (Created page with "{{Cat main|Biguanide}} {{Commons category|Biguanides}} Category:Anti-diabetic drugs Category:Guanidines")
• 19:30, 11 March 2024 Fire talk contribs created page Category:Chemical articles with multiple ChEBIs (Created page with "{{hidden category}} Populated by '''{{tl|Chembox}}''', by number of {{para|ChEBI''n''}} entries. {{TOC top}} [{{fullurl:{{FULLPAGENAME}}|from=B}} '''B (=2)'''] [{{fullurl:{{FULLPAGENAME}}|from=C}} '''C (=3)'''] [{{fullurl:{{FULLPAGENAME}}|from=D}} '''D (=4)'''] [{{fullurl:{{FULLPAGENAME}}|from=E}} '''E (=5)'''] [{{fullurl:{{FULLPAGENAME}}|from=F}} '''F (=6)'''] {{TOC bottom}} Category:Chemical articles with multiple compound IDs")
• 19:26, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/5/ja (Created page with "==遺伝子発現== {{Anchor|Gene expression}}")
• 19:26, 11 March 2024 Fire talk contribs created page Translations:Glucagon-like peptide-1/4/ja (Created page with "内因性GLP-1は主にジペプチジルペプチダーゼ-4（DPP-4）と中性エンドペプチダーゼ24.11（NEP24.11）および腎クリアランスによって速やかに分解され、その結果、半減期は約2分となる。その結果、GLP-1の10～15％しかそのまま循環に到達しないため、空腹時の血漿中濃度は0～15pmol/Lにしかならない。これを克...")
• 19:23, 11 March 2024 Fire talk contribs created page response to metformin (Q21441) (wbeditentity-create:2|en: response to metformin, Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus.)