Metformin/ja: Difference between revisions

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+年のアロン特許および''医薬品製造百科事典''に記載された手順によると、[[equivalent weight/ja|等モル]]量のジメチルアミンと2-シアノグアニジンを冷却しながら[[toluene/ja|トルエン]]に溶解して[[Concentration/ja#Qualitative description|濃縮]]溶液とし、等モル量の[[hydregen chloride/ja|塩化水素]]をゆっくりと加える。混合物はそれ自体で沸騰し始め、冷却後、メトホルミン塩酸塩が96％の[[Yield (chemistry)/ja|収率]]で[[precipitate/ja|沈殿]]する。
-According to the procedure described in the 1975 Aron patent, and the ''Pharmaceutical Manufacturing Encyclopedia'', [[equivalent weight|equimolar]] amounts of dimethylamine and 2-cyanoguanidine are dissolved in [[toluene]] with cooling to make a [[Concentration#Qualitative description|concentrated]] solution, and an equimolar amount of [[hydrogen chloride]] is slowly added. The mixture begins to boil on its own, and after cooling, metformin hydrochloride [[precipitate]]s with a 96% [[Yield (chemistry)|yield]].
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