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16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/21/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/20/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/19/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/18/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/17/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/16/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/15/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/14/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/13/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/12/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/11/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/10/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/9/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/8/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/7/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/6/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/5/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/4/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/3/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/2/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/1/en (Importing a new version from external source)
16:02, 28 March 2024 FuzzyBot talk contribs created page Translations:Telmisartan/Page display title/en (Importing a new version from external source)
16:02, 28 March 2024 Fire talk contribs marked Telmisartan for translation
16:02, 28 March 2024 Fire talk contribs limited languages for translatable page Telmisartan to Japanese
16:02, 28 March 2024 Fire talk contribs created page Template:PPAR modulators/ja (Created page with "{{Navbox | name = PPAR modulators/ja | title = {{abbrlink|PPAR|Peroxisome proliferator-activated receptor/ja}} モジュレータ | bodyclass = hlist | state = {{{state<includeonly>|collapsed</includeonly>}}} | groupstyle = text-align:center; | group1 = {{abbrlink|PPARα|Peroxisome proliferator-activated receptor alpha/ja}} | list1 = * ''作動薬:'' 15-HETE * 15-Hydroperoxy-5Z,8Z,11Z,13E-eicosatet...")
15:55, 28 March 2024 Fire talk contribs created page Template:PPAR modulators (Created page with "{{Navbox | name = PPAR modulators | title = {{abbrlink|PPAR|Peroxisome proliferator-activated receptor}} modulators | bodyclass = hlist | state = {{{state<includeonly>|collapsed</includeonly>}}} | groupstyle = text-align:center; | group1 = {{abbrlink|PPARα|Peroxisome proliferator-activated receptor alpha}} | list1 = * ''Agonists:'' 15-HETE * 15-HpETE...")
15:54, 28 March 2024 Fire talk contribs created page Category:PPAR agonists (Created page with "{{catmain|PPAR agonist}} This category lists drugs that act as agonists on peroxisome proliferator-activated receptors (PPARs). Category:Receptor agonists Category:Drugs acting on the gastrointestinal system and metabolism")
15:53, 28 March 2024 Fire talk contribs created page Category:Benzoic acids (Created page with "{{cat main|Benzoic acid}} {{Commons cat|Benzoic acids}} Category:Aromatic acids Category:Benzene derivatives")
15:53, 28 March 2024 Fire talk contribs created page Category:Benzimidazoles (Created page with "{{Commons cat|Benzimidazoles}} {{Cat main|Benzimidazole}} Category:Heterocyclic compounds with 2 rings Category:Imidazoles")
15:49, 28 March 2024 Fire talk contribs created page telmisartan (Q21576) (wbeditentity-create:2|en: telmisartan, chemical compound)
13:08, 28 March 2024 Fire talk contribs created page Telmisartan (Created page with "{{Short description|Angiotensin II receptor antagonist}} {{Drugbox | Watchedfields = changed | verifiedrevid = 477861448 | image = Telmisartan.svg | width = 220 | alt =  | pronounce = {{IPAc-en|t|ɛ|l|m|ɪ|ˈ|s|ɑr|t|ən}} | tradename = Micardis, Actavis, others | Drugs.com = {{drugs.com|monograph|telmisartan}} | MedlinePlus = a601249 | DailyMedID = Telmisartan | pregnancy_AU = D | routes_of_administration = By mouth | cla...")
12:42, 28 March 2024 Fire talk contribs created page Rational drug design/ja (Redirected page to Drug design/ja) Tag: New redirect
12:41, 28 March 2024 Fire talk contribs created page Rational drug design (Redirected page to Drug design) Tag: New redirect
12:40, 28 March 2024 Fire talk contribs created page Angiotensin receptor blockers/ja (Redirected page to アンジオテンシンII受容体拮抗薬) Tag: New redirect
12:40, 28 March 2024 Fire talk contribs created page Angiotensin receptor blockers (Redirected page to Angiotensin II receptor blocker) Tag: New redirect
12:38, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/42/ja (Created page with "ARBはすべて同じ作用機序を持っており、その効力の違いはそれぞれの薬物動態プロファイルの違いに関係している。いくつかの臨床的な直接比較が行われており、カンデサルタン、イルベサルタン、テルミサルタンはロサルタンよりも血圧を下げる効果がわずかに高いようである。この差は、受容体結合の持続時間...")
12:38, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/41/ja (Created page with "バルサルタンとオルメサルタンを除くすべてのARBは、ヒトの肝臓に存在するチトクロームP450（CYP）酵素2C9によって何らかの形で代謝される。例えば、CYP2C9はロサルタンをEXP 3174に代謝し、バルサルタンとカンデサルタンを不活性代謝物にゆっくりと代謝する。一方、テルミサルタンの一部はglucuronidation/ja|グルクロ...")
12:37, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/40/ja (Created page with "ARBは治療指数が大きいため、経口バイオアベイラビリティ（ほとんどが低い）は臨床的に重要ではないようである。表1に見られるように、これらの薬物は血漿蛋白結合性が高いため、1日1回の経口投与で十分な降圧効果が得られるはずである。経口摂取されたロサルタンの約14％は5-カルボン酸代謝物に...")
12:36, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/39/ja (Created page with "==薬物の比較と薬物動態== {{Anchor|Drug comparison and pharmacokinetics}} {| class="wikitable" border="1" |+ 表1：ARB薬物動態の比較 |- ! 薬剤 ! 生物学的半減期 [h] ! タンパク質結合率 [%] ! 生物学的利用能 [%] ! 腎/肝クリアランス [%] ! 食物の影響 ! 容量/日 [mg] |- | ロサルタン | 2 | 98.7 | 33 | 10/90 | ミネラル | 50-100 |- | EXP 3174/ja | 6-9 | 99.8 | -...")
11:14, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/38/ja (Created page with "AT1受容体に対する親和性はカンデサルタンとオルメサルタンが最も高く、次いでイルベサルタンとエプロサルタンである。バルサルタン、テルミサルタン、EXP3174は、カンデサルタンより約10倍低い親和性である。ロサルタンは最も親和性が低い。ARBのAT2受容体に対する親和性は、一般にAT1サブタイプに対する親和性よりもはるか...")
11:14, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/37/ja (Created page with "'''構造活性相関（SAR）''' ほとんどのARBは同じファーマコフォアを持っているため、その生化学的効果や生理学的効果の違いは、ほとんどが異なる置換基によるものである。薬物の活性は、基質部位に対する親和性と、その部位に結合する時間の長さに依存する。イミダゾ...")
11:09, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/36/ja (Created page with "===ファーマコフォアと構造活性相関=== '''ファーマコフォア''' ARBには3つの官能基がある。 ARBの生理活性にとって最も重要な部分は3つの官能基であり、詳細は図1を参照されたい。 1つ目はイミダゾール環で、ヘリックス7（Asn295）のアミノ酸に結合する。第二の基はビフェニルメチル基で、ヘリックス6と7の両方の...")
11:07, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/35/ja (Created page with "オルメサルタンメドキソミルは1995年に三共によって開発され、2002年に発売された最も新しいARBである。カンデサルタンシレキセチルと同様のエステル型プロドラッグである。生体内では、このプロドラッグは完全かつ速やかに加水分解され、活性酸型のオルメサルタン（RNH-6270）となる。オルメサル...")
11:06, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/34/ja (Created page with "テルミサルタンは1991年にBoehringer Ingelheimによって発見・開発され、ビフェニル酸性基としてカルボン酸を有する。ARBの中で最も消失半減期が長く、約24時間である。")
11:06, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/33/ja (Created page with "カンデサルタンシレキセチル（TCV 116）は、武田薬品で開発されたベンズイミダゾール系のエステル炭酸塩プロドラッグである。生体内では、より強力な7-カルボン酸カンデサルタンに速やかに変換される。カンデサルタンとAT1受容体との相互作用では、ベンズイミダゾール環の...")
11:05, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/32/ja (Created page with "イルベサルタンはSanofiによって開発された。バルサルタンやロサルタンよりも作用時間が長く、ロサルタンのヒドロキシメチル基の代わりにカルボニル基が水素結合受容体として機能するイミダゾリノン環を持つ。イルベサルタンは非競合阻害薬である。")
11:05, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/31/ja (Created page with "Novartisが最初に販売したバルサルタンは、非複素環式ARBである。ロサルタンのイミダゾールをアシル化アミノ酸で置き換えたARBである。")
11:04, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/30/ja (Created page with "バルサルタン、カンデサルタン、イルベサルタンはいずれも1990年に開発された。")
11:04, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/29/ja (Created page with "ロサルタンはその一部が5-カルボン酸代謝物 EXP 3174となる。EXP3174は、親化合物よりも強力なAT1受容体拮抗薬であり、他のいくつかのARBを開発し続けるモデルとなっている。")
11:03, 28 March 2024 Fire talk contribs created page Translations:Discovery and development of angiotensin receptor blockers/28/ja (Created page with "===ロサルタンから他の薬物への発展=== ロサルタン、バルサルタン、カンデサルタン、イルベサルタン、テルミサルタン、オルメサルタンはすべてビフェニルメチル基を含む。")