Calcitroic acid: Difference between revisions
Created page with "<languages /> <translate> {{chembox | ImageFile=Calcitroic acid.png | ImageSize=200px | IUPACName=(''3R'')-3-[(''1R,3aR,4E,7aR'')- 4-[(''2Z'')-2-[(''3R,5R'')-3,5- Dihydroxy-2-methylene-cyclohexylidene]ethylidene] -7a-methyl-2,3,3a,5,6,7-hexahydro-1''H'' -inden-1-yl]butanoic acid | OtherNames= |Section1={{Chembox Identifiers | ChemSpiderID = 4947800 | InChI = 1/C23H34O4/c1-14(11-22(26)27)19-8-9-20-16(5-4-10-23(19,20)3)6-7-17-12-18(24)13-21(25)15(17)2/h6-7,14,18-21,24-25H,..." |
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'''Calcitroic acid''' (1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D<sub>3</sub>) is a major [[metabolite]] of [[calcitriol|1α,25-dihydroxyvitamin D<sub>3</sub>]] (calcitriol). Around 1980, scientists first reported the isolation of calcitroic acid from the aqueous extract of radioactively treated animals' livers and intestines. Subsequent researches confirmed calcitroic acid to be a part of [[enterohepatic circulation]]. Often synthesized in the liver and kidneys, calcitroic acid is generated in the body after [[vitamin D]] is first converted into calcitriol, an intermediate in the fortification of bone through the formation and regulation of calcium in the body. These pathways managed by calcitriol are thought to be inactivated through its hydroxylation by the [[enzyme]] [[CYP24A1]], also called calcitriol 24-hydroxylase.Specifically, It is thought to be the major route to inactivate vitamin D metabolites. The hydroxylation and oxidation reactions will yield either calcitroic acid via the C24 oxidation pathway or 1,25(OH2)D3-26,23-lactone via the C23 lactone pathway. | '''Calcitroic acid''' (1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D<sub>3</sub>) is a major [[metabolite]] of [[calcitriol|1α,25-dihydroxyvitamin D<sub>3</sub>]] (calcitriol). Around 1980, scientists first reported the isolation of calcitroic acid from the aqueous extract of radioactively treated animals' livers and intestines. Subsequent researches confirmed calcitroic acid to be a part of [[enterohepatic circulation]]. Often synthesized in the liver and kidneys, calcitroic acid is generated in the body after [[vitamin D]] is first converted into calcitriol, an intermediate in the fortification of bone through the formation and regulation of calcium in the body. These pathways managed by calcitriol are thought to be inactivated through its hydroxylation by the [[enzyme]] [[CYP24A1]], also called calcitriol 24-hydroxylase.Specifically, It is thought to be the major route to inactivate vitamin D metabolites. The hydroxylation and oxidation reactions will yield either calcitroic acid via the C24 oxidation pathway or 1,25(OH2)D3-26,23-lactone via the C23 lactone pathway. | ||
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Hydroxylation and further metabolism of calcitriol in the liver and the kidneys yields calcitroic acid, a water-soluble compound that is excreted in [[bile]]. | Hydroxylation and further metabolism of calcitriol in the liver and the kidneys yields calcitroic acid, a water-soluble compound that is excreted in [[bile]]. | ||
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In case where a higher concentration of this acid is used in vitro, studies determined that calcitroic acid binds to vitamin D receptor (VDR) and induces gene transcription. | In case where a higher concentration of this acid is used in vitro, studies determined that calcitroic acid binds to vitamin D receptor (VDR) and induces gene transcription. | ||
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The compound has been prepared in the laboratory. | The compound has been prepared in the laboratory. | ||
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{{Vitamins}} | {{Vitamins}} | ||
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{{二次利用|date=11 December 2023}} | {{二次利用|date=11 December 2023}} | ||
[[Category:Secosteroids]] | [[Category:Secosteroids]] | ||