Adenosylcobalamin: Difference between revisions
Created page with "{{Short description|Biologically active form of vitamin B12}} {{Drugbox | Verifiedfields = changed | verifiedrevid = 447929261 | IUPAC_name = Coα-[α-(5,6-dimethylbenzimidazolyl)]-Coβ-<br>(5'-deoxy-5'-adenosyl)cobamide | image = AdoCbl-ColorCoded.png | image2 = Cobamamide 3D sticks.png <!--Clinical data--> | tradename = | Drugs.com = {{drugs.com|international|cobamamide}} | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = <!-- A / B / C..." |
Marked this version for translation |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
<languages /> | |||
<translate> | |||
<!--T:1--> | |||
{{Short description|Biologically active form of vitamin B12}} | {{Short description|Biologically active form of vitamin B12}} | ||
{{Drugbox | {{Drugbox | ||
| Line 50: | Line 53: | ||
'''Adenosylcobalamin''' (AdoCbl), also known as '''coenzyme B<sub>12</sub>''', '''cobamamide''', and '''dibencozide''', is, along with [[methylcobalamin]] (MeCbl), one of the biologically active forms of [[vitamin B12|vitamin B<sub>12</sub>]]. | '''Adenosylcobalamin''' (AdoCbl), also known as '''coenzyme B<sub>12</sub>''', '''cobamamide''', and '''dibencozide''', is, along with [[methylcobalamin]] (MeCbl), one of the biologically active forms of [[vitamin B12|vitamin B<sub>12</sub>]]. | ||
<!--T:2--> | |||
Adenosylcobalamin participates as a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These processes require the formation of the [[deoxyadenosyl radical]] through homolytic dissociation of the carbon-cobalt bond. This bond is exceptionally weak, with a bond dissociation energy of 31 kcal/mol, which is further lowered in the chemical environment of an enzyme [[active site]]. An [[enzyme]] that uses adenosylcobalamin as a [[Cofactor (biochemistry)|cofactor]] is [[methylmalonyl-CoA mutase]] (MCM). | Adenosylcobalamin participates as a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These processes require the formation of the [[deoxyadenosyl radical]] through homolytic dissociation of the carbon-cobalt bond. This bond is exceptionally weak, with a bond dissociation energy of 31 kcal/mol, which is further lowered in the chemical environment of an enzyme [[active site]]. An [[enzyme]] that uses adenosylcobalamin as a [[Cofactor (biochemistry)|cofactor]] is [[methylmalonyl-CoA mutase]] (MCM). | ||
Further experimentation has also determined adenosylcobalamin's role in regulating expression of some bacterial genes. By binding to CarH, | <!--T:3--> | ||
Further experimentation has also determined adenosylcobalamin's role in regulating expression of some bacterial genes. By binding to CarH, AdoCbl can modulate [[carotenoid]] genes, which confer warm colors onto various plants. Carotenoid transcription is activated by sunlight, due to the response from AdoCbl. There are other photoreceptors across different bacterial communities, aside from CarH, that also have reactive capability when bound to AdoCbl. For instance, AerR is another factor that uses AdoCbl to give off purple pigmentation. Additional examination of adenosylcobalamin-bound enzymes and the development of this cofactor over time may prove to hold regulatory function of DNA and RNA. | |||
== See also == | == See also == <!--T:4--> | ||
* [[Methylcobalamin]] | * [[Methylcobalamin]] | ||
* [[Hydroxocobalamin]] | * [[Hydroxocobalamin]] | ||
| Line 62: | Line 67: | ||
* [[Nitric oxide]] | * [[Nitric oxide]] | ||
== External links == | == External links == <!--T:5--> | ||
* {{ATC|B03|BA04}} | * {{ATC|B03|BA04}} | ||
<!--T:6--> | |||
{{Enzyme cofactors}} | {{Enzyme cofactors}} | ||
{{Vitamin}} | {{Vitamin}} | ||
<!--T:7--> | |||
{{二次利用|date=25 March 2024}} | {{二次利用|date=25 March 2024}} | ||
[[Category:B vitamins]] | [[Category:B vitamins]] | ||
| Line 74: | Line 81: | ||
[[Category:Vitamers]] | [[Category:Vitamers]] | ||
[[Category:Vitamin B12]] | [[Category:Vitamin B12]] | ||
</translate> | |||