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Message definition (Glucagon-like peptide-1 ) [[Sugars]] have been associated with various [[signalling pathways]], which initiate [[depolarisation]] of the L-cell membrane causing an elevated concentration of [[cytosolic]] Ca<sup>2+</sup> which in turn induce GLP-1 secretion. [[Fatty acids]] have been associated with the mobilisation of [[intracellular]] Ca<sup>2+</sup> stores and subsequently release of Ca<sup>2+</sup> into the [[cytosol]]. The mechanisms of protein-triggered GLP-1 secretion are less clear, but the [[amino acid]] proportion and composition appear important to the stimulatory effect.
糖 は様々なシグナル伝達経路 と関連しており、L細胞膜の脱分極 を引き起こし、細胞質 濃度の上昇を引き起こす。Ca2+ の上昇を引き起こし、GLP-1の分泌を誘導する。脂肪酸 は細胞内 のCa<up>2+</up>の動員に関連付けられている。Ca2+ 貯蔵とそれに続くCa2+ の細胞質 への放出に関連している。タンパク質をトリガーとしたGLP-1分泌のメカニズムはあまり明らかではないが、アミノ酸 の割合と組成が刺激作用に重要であるようだ。