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23:10, 12 April 2024 Fire talk contribs created page paricalcitol (Q22025) (wbeditentity-create:2|en: paricalcitol, chemical compound)
23:09, 12 April 2024 Fire talk contribs created page Template:Clear left (Created page with "{{Clear|left}}<noinclude> {{Documentation|Template:Clear/doc}} </noinclude>")
23:08, 12 April 2024 Fire talk contribs created page Paricalcitol (Created page with "{{short description|Chemical compound}} {{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 445909355 | IUPAC_name = (1''R'',3''R'',7''E'',17β)-17-[(1''R'',2''E'',4''S'')-5-hydroxy-1,4,5-trimethylhex-2-en-1-yl]-9,10-secoestra-5,7-diene-1,3-diol | image = Paricalcitol.svg | width = 200px | image2 = Paricalcitol3Dan.gif | width2 = 200px  | tradename = Zemplar | Drugs.com = {{drugs.com|monograph|paricalcitol}} | MedlinePlus...")
23:05, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/12/ja (Created page with "Category:Secosteroids Category:Vitamin D {{Vitamins}}")
23:04, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/11/ja (Created page with "{{Antipsoriatics/ja}} {{Vitamin D receptor modulators/ja}}")
23:04, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/10/ja (Created page with "また、白斑やハイリーハイリー病にも使用されている。")
23:04, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/9/ja (Created page with "==用途{{Anchor|Uses}}== 皮膚細胞の過剰なターンオーバーを抑える作用があるため、通常、乾癬や慢性ひび割れ唇などの重度の乾燥肌の治療薬として、開業医や皮膚科医から処方される。軟膏またはローションとして入手できる。")
23:03, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/8/ja (Created page with "==メカニズム{{Anchor|Mechanism}}== タカルシトールは、ケラチノサイト上のビタミンD受容体と相互作用することによって、表皮の過剰な細胞のターンオーバーを抑える。")
23:03, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/7/ja (Created page with "世界保健機関の必須医薬品リストに掲載されている。")
23:02, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/6/ja (Created page with "'''タカルシトール'''（'''Tacalcitol'''）（1,24-dihydroxyvitamin D3）は合成ビタミンD3類似体である。タカルシトールは'''Curatoderm'''や'''Bonalfa'''などの名称で販売されている。")
23:02, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/5/ja (Created page with " | C=27 | H=44 | O=3 | synonyms = (1α,24''R'')-1,24-Dihydroxyvitamin D3 | smiles = O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,...")
23:02, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/4/ja (Created page with " | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 57333-96-7 | ATC_prefix = D05 | ATC_suffix = AX04 | PubChem = 5283734 | IUPHAR_ligand = 2780 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = C2W72OJ5ZU | ChEBI = 32176 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 340361 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4446823")
23:02, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/3/ja (Created page with " | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion =")
23:02, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/2/ja (Created page with " | tradename = | Drugs.com = {{drugs.com|international|tacalcitol}} | pregnancy_AU =  | pregnancy_US =  | pregnancy_category = | legal_AU =  | legal_CA =  | legal_UK =  | legal_US = <!-- OTC...")
23:02, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/1/ja (Created page with "{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 376121485 | IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol | image = Tacalcitol.svg")
23:02, 12 April 2024 Fire talk contribs created page Tacalcitol/ja (Created page with "タカルシトール") Tags: Mobile edit Mobile web edit
23:02, 12 April 2024 Fire talk contribs created page Translations:Tacalcitol/Page display title/ja (Created page with "タカルシトール")
23:02, 12 April 2024 Fire talk contribs marked Tacalcitol for translation
23:02, 12 April 2024 Fire talk contribs set the priority languages for translatable page Tacalcitol to Japanese
23:00, 12 April 2024 Fire talk contribs created page tacalcitol (Q22024) (wbeditentity-create:2|en: tacalcitol, chemical compound)
22:58, 12 April 2024 Fire talk contribs created page Tacalcitol (Created page with "<languages /> <translate> {{Short description|Chemical compound}} {{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 376121485 | IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol | image = Tacalcitol.svg  | tradename = | Drugs.com = {{drugs.com|international|tacalcitol}} | pregnancy_AU =  | pregnancy_US = <!-- A / B / C / D /...")
22:55, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/25/ja (Created page with "カルシポトリオールの代謝物は親化合物より作用が弱い。")
22:55, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/24/ja (Created page with "===薬物動態=== 適用および全身への取り込み後、カルシポトリオールは急速な肝代謝を受ける。カルシポトリオールはMC1046（α,β-不飽和ケトン類似体）に代謝され、続いてその一次代謝物である飽和ケトン類似体MC1080に代謝される。MC1080はその後ゆっくりと代謝されてカルシトロイン酸となる。")
22:55, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/23/ja (Created page with "マウス実験において、カルシポトリオールの耳および背部皮膚への局所投与は、ケラチノサイトによる上皮細胞由来サイトカインTSLPの産生を用量依存的に増加させ、高濃度ではアトピー性皮膚炎を誘発した。カルシポトリオール塗布によるTSLP産生のこのアップレギュレーションは、Calcitriol r...")
22:52, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/22/ja (Created page with "寛解型乾癬におけるカルシポトリオールの正確な機序はよくわかっていない。しかしながら、ビタミンD受容体（VDR）に対する親和性はカルシトリオールと同程度であり、カルシウム代謝を調節する活性はカルシトリオールの1％以下であることが示されている。ビタミンD受容体はステロイド/甲状腺受容体スーパー...")
22:52, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/21/ja (Created page with "===作用機序=== 乾癬の治療におけるカルシポトリオールの有効性は、骨粗鬆症の研究において、様々なビタミンDを投与された患者の観察から初めて注目された。予期せぬことに、乾癬の患者も病変数が劇的に減少した。")
22:52, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/20/ja (Created page with "==薬理学== {{Anchor|Pharmacology}}")
22:52, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/19/ja (Created page with "薬物相互作用は知られていない。")
22:51, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/18/ja (Created page with "== 相互作用 == {{Anchor|Interactions}}")
22:51, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/17/ja (Created page with ";まれである（頻度0.1%未満）： {{div col|colwidth=18em}} * アレルギー性接触皮膚炎。 * 高カルシウム血症 * 光線過敏症 * 色素沈着の変化 * 皮膚萎縮 {{div col end}}")
22:50, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/16/ja (Created page with ";一般的でない（頻度0.1-1％）： * 乾癬の増悪。")
22:50, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/15/ja (Created page with ";一般的である（1-10%の頻度）： {{div col|colwidth=18em}} * 皮膚炎 * 乾燥肌 * 紅斑 * 紅斑 * 顔面/頭皮を含む乾癬の悪化 * 発疹 {{div col end}}")
22:49, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/14/ja (Created page with "==副作用{{Anchor|Adverse effects}}== 頻度別の副作用: ;非常に多い（頻度10％以上）： * 熱感 * かゆみ * 皮膚刺激")
22:49, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/13/ja (Created page with "カルシポトリオールが光線過敏症を引き起こす可能性があるため、過度の自然光や人工光にさらされることに注意が必要である。")
22:48, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/12/ja (Created page with "==禁忌{{Anchor|Contraindications}}== 過敏症、顔面への使用、高カルシウム血症、またはビタミンD毒性の証拠は、カルシポトリオール使用の唯一の禁忌である。")
22:48, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/26/ja (Created page with "==化学{{Anchor|Chemistry}}== カルシポトリオールは白色からほぼ白色の結晶性化合物である。")
22:47, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/27/ja (Created page with "== 外部リンク == * {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/calcipotriene | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Calcipotriene }}")
22:47, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/28/ja (Created page with "{{Antipsoriatics/ja}} {{Vitamins/ja}} {{Vitamin D receptor modulators/ja}} {{Portal bar | Medicine}}")
22:47, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/29/ja (Created page with "Category:Vitamin D Category:Indanes Category:Secondary alcohols Category:Secosteroids Category:Cyclopropanes Category:World Health Organization essential medicines")
22:47, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/11/ja (Created page with "==医薬用途{{Anchor|Medical uses}}== 慢性尋常性乾癬はカルシポトリオールの主な医薬品用途である。また、円形脱毛症の治療にも使用され成功を収めている。")
22:46, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/10/ja (Created page with "カルシポトリオールは、合成コルチコステロイドベタメタゾンジプロピオン酸エステルとの固定用量合剤カルシポトリオール/ベタメタゾンジプロピオン酸エステルとしても利用可能である。この合剤は、斑状乾癬の治療に使用される。")
22:42, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/9/ja (Created page with "世界保健機関の必須医薬品リストに掲載されている。")
22:42, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/8/ja (Created page with " 1985年に特許を取得し、1991年に医療用として承認された。米国では「Dovonex」、北米以外では「Daivonex」、ドイツでは「Psorcutan」の商品名で販売されている。")
22:42, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/7/ja (Created page with " '''カルシポトリオール'''（'''Calcipotriol'''）は、ビタミンDの一種であるカルシトリオールの合成誘導体である。乾癬の治療に用いられる。乾癬性皮膚疾患への長期投与は安全である。")
22:41, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/6/ja (Created page with " | IUPAC_name = (1''R'',3''S'',5''E''<nowiki>)-5-{2-[(1</nowiki>''R'',3a''S'',4''Z'',7a''R'')-1-[(2''R'',3''E'')-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1''H''-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol | C = 27 | H = 40 | O = 3 | smiles = O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]4([C@H]2CC[C@@H]4[C@@H](/C=C/[C@@H](O)C3CC3)C)C | StdInChI_Ref...")
22:41, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/5/ja (Created page with " | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 112965-21-6 | PubChem = 5288783 | IUPHAR_ligand = 2778 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB02300 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4450880 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 143NQ3779B | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG...")
22:41, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/4/ja (Created page with " | bioavailability = 5 to 6% | metabolism = Liver/ja | excretion = 胆道")
22:41, 12 April 2024 Fire talk contribs created page Calcipotriol/ja (Created page with "カルシポトリオール")
22:41, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/3/ja (Created page with "| legal_AU = S4 | legal_CA = Rx-only | legal_UK = POM | legal_US = Rx-only | legal_status =")
22:41, 12 April 2024 Fire talk contribs created page Translations:Calcipotriol/2/ja (Created page with " | tradename = Daivonex, Dovonex, Sorilux | Drugs.com = {{drugs.com|monograph|calcitriol}} | MedlinePlus = a608018 | licence_EU = | DailyMedID = Calcipotriene | licence_US = | pregnancy_AU = B3 | pregnancy_category = | routes_of_administration = Topical administration/ja | ATC_prefix = D05 | ATC_suffix = AX02")

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