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• 19:16, 5 April 2024 FuzzyBot talk contribs created page Translations:Levomefolic acid/2/en (Importing a new version from external source)
• 19:16, 5 April 2024 FuzzyBot talk contribs created page Translations:Levomefolic acid/1/en (Importing a new version from external source)
• 19:16, 5 April 2024 FuzzyBot talk contribs created page Translations:Levomefolic acid/Page display title/en (Importing a new version from external source)
• 19:16, 5 April 2024 Fire talk contribs marked Levomefolic acid for translation
• 19:16, 5 April 2024 Fire talk contribs limited languages for translatable page Levomefolic acid to Japanese
• 19:15, 5 April 2024 Fire talk contribs created page Category:Patent case law (Created page with "{{Cat main|List of patent case law}} Case law")
• 19:15, 5 April 2024 Fire talk contribs created page Category:Medical food (Created page with "{{cat main}} {{Commons category|Medical food}} Category:Foods by type Category:Enteral feeding")
• 19:12, 5 April 2024 Fire talk contribs created page 5-methyltetrahydrofolic acid (Q21795) (wbeditentity-create:2|en: 5-methyltetrahydrofolic acid, group of stereoisomers)
• 19:10, 5 April 2024 Fire talk contribs created page levomefolic acid (Q21794) (wbeditentity-create:2|en: levomefolic acid, chemical compound)
• 19:10, 5 April 2024 Fire talk contribs created page Template:Citation/make link (Created page with "{{#if:{{{1|}}} |[{{{1}}} {{{2}}}] |{{{2}}} }}<noinclude><!-- Code notes (here so that people /read/ it) 1. Parameter #2 is always nonempty when called from {{Citation/core}}. 2. It's up to {{Citation/core}} to stop italicized "'foo' & 'bar'" from becoming "'''foo' & 'bar'''". Citation/core does this by having a <nowiki></nowiki> at both beginning and end of the call to this template. Since this is only needed once, it's more efficient to do it in {...")
• 19:09, 5 April 2024 Fire talk contribs created page Template:Citation/styles.css (Created page with "* This page is a convenient place for the "citation" styles that are * available in many of our citation templates. This page can be considered the * authoritative source for those styles. Template:Citation, like all CS1/2 * templates, is styled from Module:Citation/CS1/styles.css, *not* here.: Break long urls, etc., rather than overflowing box: .citation { word-wrap: break-word; } /* Highlight linked elements (such as clicked references) in blue...")
• 19:09, 5 April 2024 Fire talk contribs created page Template:Cite patent/core (Created page with "<templatestyles src="Citation/styles.css"/><span class="citation patent"{{#ifeq:{{{Ref|}}}|none||{{#if:{{{Ref|}}}|id="{{anchorencode:{{{Ref|}}}}}"|{{#if:{{{Surname1|}}}{{{EditorSurname1|}}} |id="CITEREF{{anchorencode:{{#if:{{{Surname1|}}} |{{{Surname1}}}{{{Surname2|}}}{{{Surname3|}}}{{{Surname4|}}} |{{{EditorSurname1|}}}{{{EditorSurname2|}}}{{{EditorSurname3|}}}{{{EditorSurname4|}}} }}{{#if:{{{RefDate|}}}|{{#time:Y|{{{RefDate|}}}}}}}}}"}}}}}}>{{citation/make_link | 1={...")
• 19:08, 5 April 2024 Fire talk contribs created page Template:UnitedStatesCodeSub (Created page with "<span class=plainlinksneverexpand>{{#if:{{{pipe|}}}|[https://www.law.cornell.edu/uscode/text/{{Trim|{{{1}}}}}/{{Trim|{{{2}}}}}{{#if:{{{3|}}}|#{{Trim|{{{3}}}}}{{#if:{{{4|}}}|_{{Trim|{{{4}}}}}{{#if:{{{5|}}}|_{{Trim|{{{5}}}}}{{#if:{{{6|}}}|_{{Trim|{{{6}}}}}{{#if:{{{7|}}}|_{{Trim|{{{7}}}}}{{#if:{{{8|}}}|_{{Trim|{{{8}}}}}|}}|}}|}}|}}|}}|}} {{{pipe}}}]|{{#switch:{{{1}}}| 26 = 26 U.S.C. |[[Title {{{1}}} of the United States Code|{{{1}}} U.S.C.]]}}&...")
• 19:08, 5 April 2024 Fire talk contribs created page Template:Uscsub (Redirected page to Template:UnitedStatesCodeSub) Tag: New redirect
• 19:08, 5 April 2024 Fire talk contribs created page Template:Cite patent (Created page with "<includeonly>{{cite patent/core |Surname1 = {{#if:{{{inventor|}}}|{{{inventor}}}|{{{inventor-surname|{{{inventor1-surname|{{{inventor-last|{{{inventor1-last|{{{inventor-last1|{{{invent-1|{{{invent1|}}}}}}}}}}}}}}}}}}}}} }} |Surname2={{{inventor2-surname|{{{inventor2-last|{{{inventor-last2|{{{inventor2|{{{invent2|}}}}}}}}}}}}}}} |Surname3={{{inventor3-surname|{{{inventor3-last|{{{inventor-last3|{{{inventor3|{{{invent3|}}}}}}}}}}}}}}} |Surname4={{{inventor4-surname|{{{...")
• 19:07, 5 April 2024 Fire talk contribs created page Template:Patent (Created page with "<includeonly>{{Cite patent |1={{{1|US}}} |2={{{2|0}}} |3={{#ifeq:{{{3}}}|application|application}} }}{{#ifeq:{{{3}}}|application |{{#if:{{{4|}}}| {{{4}}}}} |{{#if:{{{3|}}}| {{{3}}}}} }}</includeonly><noinclude> {{Documentation}} </noinclude>")
• 19:06, 5 April 2024 Fire talk contribs created page Template:Chembox Legal status/format (Redirected page to Template:Infobox drug/legal status) Tag: New redirect
• 19:06, 5 April 2024 Fire talk contribs created page Template:Chembox Legal status (Created page with "| Legal status | {{Chembox Legal status/format<!-- redirects to Template:Infobox drug/legal status --> |legal_AU={{{legal_AU|}}} |legal_BR={{{legal_BR|}}} |legal_CA={{{legal_CA|}}} |legal_DE={{{legal_DE|}}} |legal_NZ={{{legal_NZ|}}} |legal_UK={{{legal_UK|}}} |legal_US={{{legal_US|}}} |legal_EU={{{legal_EU|}}} |legal_UN={{{legal_UN|}}} |legal_AU_comment={{{legal_AU_comment|}}} |legal_BR_comment={{{legal_BR_comment|}}} |legal...")
• 19:05, 5 April 2024 Fire talk contribs created page Levomefolic acid (Created page with "<languages /> <translate> {{chembox | ImageFile=5-Methyltetrahydrofolate.png | ImageSize=220px | IUPACName=(2''S'')-2-[ [4-[(2-Amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl) methylamino]benzoyl]amino]pentanedioic acid | OtherNames=(<small>L</small>-5-Me-THFA, <small>L</small>-5-Me-H₄FA),<br />anion: <small>L</small>-5-methyltetrahydrofolate (<small>L</small>-5-Me-THF, <small>L</small>-5-Me-H₄F), <small>L</small>-methylfolate<br>Metafolin |Se...")
• 19:00, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/24/ja (Created page with "フォリン酸にはデキストロ異性体とレボロタリ異性体がある。レボロイコボリン（レボロタリ異性体）とラセミ体フォリン酸（両異性体の混合物）は、いずれも同様の有効性と忍容性を有する。レボロイコボリンは2008年にFDAによって承認された。")
• 19:00, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/23/ja (Created page with "したがって、フォリン酸は、ジヒドロ葉酸還元酵素阻害の存在下でも、ある程度のプリン/ピリミジン合成を可能にし、正常なDNA複製過程を進行させることができる。")
• 18:59, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/22/ja (Created page with "そのメカニズムはあまり明らかではないが、悪性細胞におけるメトトレキサートとジヒドロ葉酸のポリグルタミル化は、正常細胞におけるフォリン酸によるジヒドロ葉酸還元酵素の選択的再活性化に重要な役割を果たしていると考えられている。")
• 18:59, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/21/ja (Created page with "== 作用機序 == {{Anchor|Mechanism of action}} フォリン酸はテトラヒドロ葉酸の5-ホルミル誘導体である。他の還元型葉酸誘導体（5,10-メチレンテトラヒドロ葉酸、5-メチルテトラヒドロ葉酸など）に容易に変換されるため、葉酸と同等のビタミン活性を有する。その変換にはdihydrofolate reduc...")
• 18:58, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/20/ja (Created page with "スルファメトキサゾール-トリメトプリム： スルファメトキサゾール-トリメトプリムとフォリン酸の併用には潜在的な薬物相互作用が存在する。フォリン酸は、AIDS患者の肺炎の一般的な原因である''ニューモシスチス・ジロベシイ''（旧称'''ニューモシスチス・カリニイ'''）の治療におけるスルファメト...")
• 18:57, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/19/ja (Created page with "== 薬物相互作用 == {{Anchor|Drug interactions}} フルオロウラシル： この2つを一緒に投与すると、コリン酸はフルオロウラシルに関連する毒性を増大させることがある。特に高齢の患者で発生した副作用には、重度の腸炎、下痢、脱水がある。")
• 18:56, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/18/ja (Created page with "がん患者では、まれにフォリン酸に対する過敏症反応が報告されている。")
• 18:56, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/17/ja (Created page with "== 副作用 == フォリン酸は髄腔内投与すべきではない。重篤な副作用を引き起こす可能性があり、死に至ることもある。")
• 18:55, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/25/ja (Created page with "== 歴史 == {{Anchor|History}} フォリン酸は、1948年にザウバーリッヒとバウマンによって、細菌''Leuconostoc citrovorum''に必要な増殖因子として発見された。その結果、シトロボルム増殖因子を意味する「シトロボルム因子」と呼ばれるようになった。シトロボルム因子は未知の構造を持つが、葉酸の誘導体であり、肝臓で代謝されなければ''...")
• 18:18, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/16/ja (Created page with "ピリドキシン依存性てんかんでは、ピリドキシンまたはピリドキサールリン酸が発作を完全に制御できない場合、追加療法としてフォリン酸が使用されることがある。")
• 18:18, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/15/ja (Created page with "また、葉酸を使用しても5-MTHFの脳脊髄液レベルを正常化できない症候群である脳性葉酸欠乏症の治療にも用いられる。")
• 18:17, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/14/ja (Created page with "また、トリメトプリムやピリメタミンなどの抗菌薬ジヒドロ葉酸還元酵素阻害薬の高用量投与による毒性作用を防ぐために、コリン酸が使用されることもあるが、この適応に対する価値は明確に確立されていない。 葉酸拮抗薬であるピリメタミンやスルファジアジンとの併用...")
• 18:15, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/13/ja (Created page with "フォリン酸はまた、結腸がんの治療において化学療法剤5-フルオロウラシルと併用される。この場合、フォリン酸は「救済」目的で使用されるのではなく、むしろチミジル酸合成酵素を阻害することによって5-フルオロウラシルの効果を増強する。")
• 18:15, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/12/ja (Created page with "さらに、フォリン酸は関節リウマチ患者におけるメトトレキサートの副作用を軽減するために用いられることもある。これには、吐き気、腹痛、肝血液検査異常、口内炎の軽減が含まれる。")
• 18:14, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/11/ja (Created page with "特にメトトレキサートの解毒剤ではないが、フォリン酸は急性メトトレキサート過量投与の治療にも有用である。さまざまな投与プロトコールが用いられるが、メトトレキサート濃度が5×10^-8 M未満になるまで、フォリン酸を再投与すべきである。")
• 18:14, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/10/ja (Created page with "== 医療用途 == {{Anchor|Medical use}} thumb|レボフォリン酸 フォリン酸は、骨髄抑制または消化管粘膜の炎症から保護する可能性があり、総化学療法計画の一部としてメトトレキサートに続いて投与される。既存のメトトレキサート誘発性の腎毒性に対する明らかな効果はみられない...")
• 18:12, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/9/ja (Created page with "<!-- History and culture --> フォリニック酸は1945年に初めて製造された。世界保健機関の必須医薬品リストに掲載されている。")
• 18:12, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/8/ja (Created page with "<!-- Side effects and mechanism --> 副作用には、睡眠障害、アレルギー反応、または発熱が含まれることがある。妊娠中または授乳中の使用は一般的に安全とみなされている。貧血に使用する場合は、まず原因として悪性貧血を除外することが推奨される。コリン酸はdihydrofolate reductase...")
• 18:10, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/27/ja (Created page with "一般に、カルシウム塩またはナトリウム塩として投与される（フォリナートカルシウム（INN）、フォリナートナトリウム、ロイコボリンカルシウム、ロイコボリンナトリウム）。")
• 18:10, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/26/ja (Created page with "==名称== フォリン酸は葉酸（ビタミンB₉）と区別されるべきである。しかし、フォリン酸は葉酸のビタマーであり、このビタミンの完全なビタミン活性を持つ。レボホリニック酸とその塩は分子の2S形である。これらは、生物学的に活性であることが知られている分子の唯一の形態である。")
• 18:02, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/28/ja (Created page with "== 外部リンク == * {{cite web | title=Leucovorin | website=MedlinePlus | url=https://medlineplus.gov/druginfo/meds/a682336.html }}")
• 18:02, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/29/ja (Created page with "{{Detoxifying agents for antineoplastic treatment/ja}} {{Vitamin/ja}} {{Portal bar|Medicine}}")
• 18:02, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/30/ja (Created page with "Category:Chemotherapeutic adjuvants Category:Folates Category:World Health Organization essential medicines Category:Wikipedia medicine articles ready to translate")
• 18:01, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/7/ja (Created page with "<!-- Definition and medical uses --> '''ロイコボリン'''としても知られる'''フォリン酸'''は、メトトレキサートとピリメタミンの毒性作用を低下させるために用いられる医薬品である。また、大腸がんや膵臓がんの治療に5-フルオロウラシルと併用されたり、貧血を引き起こすfolate deficie...")
• 17:59, 5 April 2024 Fire talk contribs created page Folinic acid/ja (Created page with "{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470454241 | image = Folinic acid.svg | alt = フォリン酸の骨格式 | width = 250 | image2 = Leucovorin molecule ball.png | alt2 = フォリン酸分子のボール＆スティック・モデル")
• 17:59, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/6/ja (Created page with "<!--Chemical data--> | IUPAC_name = (''2S'')-2-<nowiki/>{[4-[(2-amino-5-formyl-4-oxo-5,6,7,8-<br />tetrahydro-1''H''-pteridin-6-yl)methylamino]<br />benzoyl]amino}pentanedioic acid | C=20 | H=23 | N=7 | O=7 | SMILES = O=C(O)[C@@H](NC(=O)c1ccc(cc1)NCC3N(/C2=C(/N/C(=N\C2=O)N)NC3)C=O)CCC(=O)O | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h...")
• 17:59, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/5/ja (Created page with "<!--Identifiers--> | IUPHAR_ligand = 4816 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 1492-18-8 | PubChem = 6006 | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = DB00650 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 5784 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = RPR1R4C0P4 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1679 | synonyms = citrovorum factor, 5-formyltetrahydrofolate")
• 17:58, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/4/ja (Created page with "<!-- Pharmacokinetic data --> | bioavailability = Dose dependent | protein_bound = ~15% | metabolism = | elimination_half-life = 6.2 hours | excretion = Kidney/ja")
• 17:58, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/3/ja (Created page with "<!-- Legal status --> | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> | legal_AU_comment = | legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> | legal_BR_comment = | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA_comment = | legal_DE = <!-- Anlage I, II, III or Unscheduled --> | legal_DE_comment = | legal_NZ = <!-- Class A, B, C --> | legal_NZ_comment = | legal_UK = <!-- GSL, P, POM,...")
• 17:58, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/2/ja (Created page with "<!--Clinical data--> | pronounce = Leucovorin {{IPAc-en|ˌ|lj|uː|k|oʊ|ˈ|v|ɔː|r|ɪ|n}} | tradename = Many | Drugs.com = {{drugs.com|monograph|leucovorin-calcium}} | MedlinePlus = a608038 | DailyMedID = Leucovorin calcium | pregnancy_AU = A | routes_of_administration = 静脈内注射, IM, 口から | ATC_prefix = V03 | ATC_suffix = AF03")
• 17:58, 5 April 2024 FuzzyBot talk contribs created page Folinic acid/en (Updating to match new version of source page)