Paricalcitol: Difference between revisions

Line 23:

| routes_of_administration = Oral, Intravenous

| bioavailability = 72%~~<ref name = MSR/>~~

| bioavailability = 72%

| protein_bound = 99.8%~~<ref name = MSR/>~~

| protein_bound = 99.8%

| metabolism = [[Hepatic]]~~<ref name = MSR/>~~

| metabolism = [[Hepatic]]

| elimination_half-life = 14-20 hours~~<ref name = MSR/>~~

| elimination_half-life = 14-20 hours

| excretion = Faeces (74%), urine (16%)~~<ref name = MSR/>~~

| excretion = Faeces (74%), urine (16%)

| CAS_number_Ref = {{cascite|correct|??}}

Line 199:

==Overdose==

Electrolyte abnormalities (e.g. [[hypercalcaemia]] and [[hyperphosphataemia]]) are common overdose symptoms. Treatment is mostly supportive, with particular attention being paid to correcting electrolyte anomalies and reducing intake of calcium in both the form of supplementation and diet.~~<ref name = EMC/>~~ As it is so heavily bound to plasma proteins [[haemodialysis]] is unlikely to be helpful in cases of overdose.

Electrolyte abnormalities (e.g. [[hypercalcaemia]] and [[hyperphosphataemia]]) are common overdose symptoms. Treatment is mostly supportive, with particular attention being paid to correcting electrolyte anomalies and reducing intake of calcium in both the form of supplementation and diet. As it is so heavily bound to plasma proteins [[haemodialysis]] is unlikely to be helpful in cases of overdose.

Early symptoms of overdose can include:

@@ Line 23: / Line 23: @@
 | routes_of_administration = Oral, Intravenous
 <!--Pharmacokinetic data-->
-| bioavailability = 72%<ref name = MSR/>
+| bioavailability = 72%
-| protein_bound = 99.8%<ref name = MSR/>
+| protein_bound = 99.8%
-| metabolism = [[Hepatic]]<ref name = MSR/>
+| metabolism = [[Hepatic]]
-| elimination_half-life = 14-20 hours<ref name = MSR/>
+| elimination_half-life = 14-20 hours
-| excretion = Faeces (74%), urine (16%)<ref name = MSR/>
+| excretion = Faeces (74%), urine (16%)
 <!--Identifiers-->
 | CAS_number_Ref = {{cascite|correct|??}}
@@ Line 199: / Line 199: @@
 ==Overdose==
-Electrolyte abnormalities (e.g. [[hypercalcaemia]] and [[hyperphosphataemia]]) are common overdose symptoms. Treatment is mostly supportive, with particular attention being paid to correcting electrolyte anomalies and reducing intake of calcium in both the form of supplementation and diet.<ref name = EMC/> As it is so heavily bound to plasma proteins [[haemodialysis]] is unlikely to be helpful in cases of overdose.
+Electrolyte abnormalities (e.g. [[hypercalcaemia]] and [[hyperphosphataemia]]) are common overdose symptoms. Treatment is mostly supportive, with particular attention being paid to correcting electrolyte anomalies and reducing intake of calcium in both the form of supplementation and diet. As it is so heavily bound to plasma proteins [[haemodialysis]] is unlikely to be helpful in cases of overdose.
 Early symptoms of overdose can include: