Methylcobalamin: Difference between revisions

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'''Methylcobalamin''' (mecobalamin, MeCbl, or MeB{{sub|12}}) is a [[cobalamin]], a form of [[vitamin B12|vitamin B{{sub|12}}]]. It differs from [[cyanocobalamin]] in that the [[cyanide|cyano group]] at the cobalt is replaced with a [[methyl group]]. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals.~~<ref name="MechB12" />~~ From the perspective of [[coordination chemistry]], methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. [[Nickel]]–methyl intermediates have been proposed for the final step of [[methanogenesis]].

'''Methylcobalamin''' (mecobalamin, MeCbl, or MeB{{sub|12}}) is a [[cobalamin]], a form of [[vitamin B12|vitamin B{{sub|12}}]]. It differs from [[cyanocobalamin]] in that the [[cyanide|cyano group]] at the cobalt is replaced with a [[methyl group]]. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. From the perspective of [[coordination chemistry]], methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. [[Nickel]]–methyl intermediates have been proposed for the final step of [[methanogenesis]].

Methylcobalamin is equivalent physiologically to vitamin B{{sub|12}}, and can be used to prevent or treat pathology arising from a lack of vitamin B{{sub|12}} intake ([[vitamin B12 deficiency|vitamin B<sub>12</sub> deficiency]]).

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 | C=63 | H=91 | Co=1 | N=13 | O=14 | P=1
 |drug_name=|alt=|caption=|type=|MedlinePlus=|licence_EU=|licence_US=}}
-'''Methylcobalamin''' (mecobalamin, MeCbl, or MeB{{sub|12}}) is a [[cobalamin]], a form of [[vitamin B12|vitamin B{{sub|12}}]]. It differs from [[cyanocobalamin]] in that the [[cyanide|cyano group]] at the cobalt is replaced with a [[methyl group]]. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals.<ref name="MechB12" />  From the perspective of [[coordination chemistry]], methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. [[Nickel]]–methyl intermediates have been proposed for the final step of [[methanogenesis]].
+'''Methylcobalamin''' (mecobalamin, MeCbl, or MeB{{sub|12}}) is a [[cobalamin]], a form of [[vitamin B12|vitamin B{{sub|12}}]]. It differs from [[cyanocobalamin]] in that the [[cyanide|cyano group]] at the cobalt is replaced with a [[methyl group]]. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals.  From the perspective of [[coordination chemistry]], methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. [[Nickel]]–methyl intermediates have been proposed for the final step of [[methanogenesis]].
 Methylcobalamin is equivalent physiologically to vitamin B{{sub|12}}, and can be used to prevent or treat pathology arising from a lack of vitamin B{{sub|12}} intake ([[vitamin B12 deficiency|vitamin B<sub>12</sub> deficiency]]).