Citric acid cycle/ja: Difference between revisions

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== 循環乳酸を介してTCAサイクルに供給されるグルコース ==

== Glucose feeds the TCA cycle via circulating lactate ==

~~The~~ [[~~Metabolic pathway~~|~~metabolic~~]] ~~role of~~ [[~~Lactic acid~~|~~lactate~~]] ~~is well recognized as a fuel for~~ [[Tissue (biology)|~~tissue~~]]s, [[~~mitochondrial disease~~|~~mitochondrial cytopathies~~]] ~~such as~~ [[~~DPH Cytopathy~~]]~~, and the scientific field of~~ [[oncology]] ([[Neoplasm|~~tumor~~]]~~s). In the classical~~ [[~~Cori~~ cycle]]~~, muscles produce lactate which is then taken up by the~~ [[liver]] ~~for~~ [[gluconeogenesis]]~~. New studies suggest that lactate can be used as a source of~~ [[carbon]] ~~for the TCA cycle.~~

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== 進化 ==

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+== 循環乳酸を介してTCAサイクルに供給されるグルコース ==
-== Glucose feeds the TCA cycle via circulating lactate ==
+{{Anchor|Glucose feeds the TCA cycle via circulating lactate}}
-The [[Metabolic pathway|metabolic]] role of [[Lactic acid|lactate]] is well recognized as a fuel for [[Tissue (biology)|tissue]]s, [[mitochondrial disease|mitochondrial cytopathies]] such as [[DPH Cytopathy]], and the scientific field of [[oncology]] ([[Neoplasm|tumor]]s). In the classical [[Cori cycle]], muscles produce lactate which is then taken up by the [[liver]] for [[gluconeogenesis]]. New studies suggest that lactate can be used as a source of [[carbon]] for the TCA cycle.
+[[Lactic acid/ja|乳酸]]の[[Metabolic pathway/ja|代謝]]的役割は、[[Tissue (biology)/ja|組織]]、[[DPH Cytopathy/ja|DPH細胞症]]などの[[mitochondrial disease/ja|ミトコンドリア細胞症]]、および[[oncology/ja|腫瘍学]]の科学分野（[[Neoplasm/ja|腫瘍]]）の燃料としてよく認識されている。古典的な[[cori cycle/ja|コリサイクル]]では、筋肉が乳酸を産生し、それが[[liver/ja|肝臓]]で[[gluconeogenesis/ja|糖新生]]のために取り込まれる。新しい研究では、乳酸はTCAサイクルの[[carbon/ja|炭素]]源として使用できることが示唆されている。
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 == 進化 ==