Prosultiamine/ja: Difference between revisions

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'''~~Prosultiamine~~''' ([[International Nonproprietary Name|INN]]~~; also known as~~ '''~~thiamine propyl disulfide~~''' or '''TPD'''~~; brand name~~ '''~~Jubedel~~'''~~,) is a~~ [[disulfide]] [[thiamine]] [[derivative (chemistry)|~~derivative~~]] ~~discovered in garlic in [[Japan]] in the 1950s, and is similar to~~ [[allithiamine]]~~. It was developed as a treatment for~~ [[Thiamine#Deficiency|~~vitamin B~~<sub>1</sub> ~~deficiency~~]]~~. It has improved~~ [[lipid]] [[solubility]] ~~relative to thiamine and is not rate-limited by dependency on intestinal~~ [[membrane transport protein|~~transporter~~]]~~s for absorption, hence the reasoning for its development.~~

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+'''プロスルチアミン'''（[[:en:International Nonproprietary Name|INN]]、別名'''チアミンプロピルジスルフィド'''または'''TPD'''、商品名'''ジュベデル'''）は、1950年代に[[:ja:日本|日本]]のニンニクから発見された[[disulfide/ja|ジスルフィド]][[thiamine/ja|チアミン]][[derivative (chemistry)/ja|誘導体]]である。[[allithiamine/ja|アリチアミン]]に類似している。[[Thiamine/ja#Deficiency|ビタミンB<sub>1</sub>欠乏症]]の治療薬として開発された。[[lipid/ja|脂質]][[solubility/ja|溶解性]]が改善されており、吸収のための腸管[[membrane transport protein/ja|トランスポーター]]への依存による速度制限がないことが開発の理由である。
-'''Prosultiamine''' ([[International Nonproprietary Name|INN]]; also known as '''thiamine propyl disulfide''' or '''TPD'''; brand name '''Jubedel''',) is a [[disulfide]] [[thiamine]] [[derivative (chemistry)|derivative]] discovered in garlic in [[Japan]] in the 1950s, and is similar to [[allithiamine]]. It was developed as a treatment for [[Thiamine#Deficiency|vitamin B<sub>1</sub> deficiency]]. It has improved [[lipid]] [[solubility]] relative to thiamine and is not rate-limited by dependency on intestinal [[membrane transport protein|transporter]]s for absorption, hence the reasoning for its development.
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