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Message definition (Sulfonylurea ) Sulfonylureas bind to and close [[ATP-sensitive potassium channel|ATP-sensitive K<sup>+</sup>]] (K<sub>ATP</sub>) channels on the cell membrane of pancreatic [[beta cell]]s, which depolarizes the cell by preventing potassium from exiting. This [[depolarization]] opens voltage-gated [[calcium|Ca]]<sup>2+</sup> channels. The rise in intracellular calcium leads to increased fusion of [[insulin]] granules with the cell membrane, and therefore increased [[Insulin#Synthesis|secretion]] of mature insulin.
スルホニル尿素は、膵β細胞 の細胞膜上のATP感受性K+ (KATP )チャネルに結合して閉じ、カリウムが外に出るのを妨げることによって細胞を脱分極させる。この脱分極 は、電位依存性Ca 2+ チャネルを開く。細胞内カルシウムの上昇は、インスリン 顆粒と細胞膜の融合を増加させ、成熟インスリンの分泌 を増加させる。