Main public logs

Combined display of all available logs of Azupedia. You can narrow down the view by selecting a log type, the username (case-sensitive), or the affected page (also case-sensitive).

23:06, 22 April 2024 Fire talk contribs created page Translations:Collagen/56/ja (Created page with "* Category:Structural proteins Category:Edible thickening agents Category:Aging-related proteins")
23:06, 22 April 2024 Fire talk contribs created page Translations:Collagen/3/ja (Created page with "==語源{{Anchor|Etymology}}== thumb|コラーゲン")
23:05, 22 April 2024 Fire talk contribs created page Translations:Collagen/2/ja (Created page with "'''コラーゲン'''({{IPAc-en|ˈ|k|ɒ|l|ə|dʒ|ə|n}})は、主に軟骨、骨、腱、靭帯、皮膚などの身体の様々な結合組織に見られる細胞外マトリックスの主要な構造タンパク質である。結合組織の主成分として、哺乳類において最も豊富なタンパク質であり、全身...")
22:56, 22 April 2024 Fire talk contribs created page Translations:Collagen/1/ja (Created page with "thumb|upright=1.5|トロポコラーゲン分子：3つの左巻きプロコラーゲン（赤、緑、青）が結合し、右巻き三重らせんトロポコラーゲンを形成する。")
22:56, 22 April 2024 Fire talk contribs created page Collagen/ja (Created page with "コラーゲン")
22:55, 22 April 2024 Fire talk contribs created page Translations:Collagen/Page display title/ja (Created page with "コラーゲン")
22:55, 22 April 2024 Fire talk contribs marked Collagen for translation
22:55, 22 April 2024 Fire talk contribs limited languages for translatable page Collagen to Japanese
22:51, 22 April 2024 Fire talk contribs created page Saimiri transformation-associated protein (Q22175) (wbeditentity-create:2|en: Saimiri transformation-associated protein, InterPro Family)
22:50, 22 April 2024 Fire talk contribs created page Collagen triple helix repeat (Q22174) (wbeditentity-create:2|en: Collagen triple helix repeat, InterPro Repeat)
22:49, 22 April 2024 Fire talk contribs created page collagen triple helix repeat, protein family (Q22173) (wbeditentity-create:2|en: collagen triple helix repeat, protein family, protein family)
22:48, 22 April 2024 Fire talk contribs created page extracellular matrix proteins (Q22172) (wbeditentity-create:2|en: extracellular matrix proteins, macromolecules forming an intricate meshwork in which cells are embedded to construct tissues)
22:47, 22 April 2024 Fire talk contribs created page collagen (Q22171) (wbeditentity-create:2|en: collagen, group of fibrous proteins that occur in vertebrates as the chief constituent of connective tissue fibrils and in bones and yield gelatin and glue upon boiling with water)
22:46, 22 April 2024 Fire talk contribs created page Template:See also cat (Redirected page to Template:Category see also) Tag: New redirect
22:46, 22 April 2024 Fire talk contribs created page Category:Aging-related proteins (Created page with "{{See also cat|Aging-related genes}} Category:Senescence Category:Proteins by function")
22:45, 22 April 2024 Fire talk contribs created page Template:Category main section (Created page with "{{Hatnote|extraclasses=relarticle mainarticle|The main section for this category is {{#ifeq:{{{article|}}}|no|on the page|in the article}} [[{{{1}}}]], in the section titled [[{{{1}}}#{{{2}}}|{{{2}}}]].}}<noinclude>  {{Documentation}} </noinclude>")
22:45, 22 April 2024 Fire talk contribs created page Category:Structural proteins (Created page with "{{Category main section|Protein|Structural proteins}} {{Commons category|Structural proteins}} Category:Proteins by function")
22:44, 22 April 2024 Fire talk contribs created page Category:Collagens (Created page with "{{Commons category|Collagen}} Category:Extracellular matrix proteins")
22:43, 22 April 2024 Fire talk contribs created page Template:Fibrous proteins/ja (Created page with "{{Navbox | name = Fibrous proteins/ja | title = タンパク質: scleroprotein/ja | bodyclass = hlist | titlestyle = background:#e7dcc3 | basestyle = background-color: AntiqueWhite | group1 = 細胞外 マトリックス | list1 = {{Navbox|subgroup | groupstyle = background-color: AntiqueWhite | group1 = コラーゲン | list1 = {{Navbox|subgroup | groupstyle = background-color: AntiqueWhite | group1...")
22:36, 22 April 2024 Fire talk contribs created page Template:Fibrous proteins (Created page with "{{Navbox | name = Fibrous proteins | title = Protein: scleroproteins | bodyclass = hlist | titlestyle = background:#e7dcc3 | basestyle = background-color: AntiqueWhite | group1 = Extracellular matrix | list1 = {{Navbox|subgroup | groupstyle = background-color: AntiqueWhite | group1 = Collagen | list1 = {{Navbox|subgroup | groupstyle = background-color: AntiqueWhite | group1 = Fibril forming...")
22:35, 22 April 2024 Fire talk contribs created page Collagen (Created page with "{{Short description|Most abundant structural protein in animals}} thumb|upright=1.5|Tropocollagen molecule: three left-handed procollagens (red, green, blue) join to form a right-handed triple helical tropocollagen. '''Collagen''' ({{IPAc-en|ˈ|k|ɒ|l|ə|dʒ|ə|n}}) is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component of connective tissue, it is the...")
20:40, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/18/ja (Created page with "Ipsenは2008年4月に欧州医薬品庁からフェブキソスタットの販売承認を取得し、武田薬品工業は2009年2月にFDAの承認を取得、帝人は2011年に日本の当局から承認を取得した。Ipsenは2009年にMenariniに欧州での独占的な権利をライセンスした。帝人は中国と東南アジアでの販売でアステラス製薬と提携...")
20:39, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/17/ja (Created page with "==歴史{{Anchor|History}}== thumb|right|250px|FEBURIC (Febuxostat) 80 mgタブレットフェブキソスタットは1998年に日本の製薬会社帝人の科学者によって発見された。帝人はこの薬物をアメリカではTAP Pharmaceuticals、ヨーロッパではIpsenと提携した。")
20:38, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/16/ja (Created page with "thumb|right|ヒトにおける[[active metabolite/ja|活性代謝物：67M-1、67M-2、67M-4（上から下へ）]] フェブキソスタットにはヒトにおいて3つの活性代謝物があり、それらは主に多くのチトクロームP450肝酵素（CYP1A1、1A2、2C8、2C9）によって生成される。そのうちの1つはdicarboxyl...")
20:36, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/15/ja (Created page with "=== 薬物動態 === 経口摂取後、フェブキソスタット用量の少なくとも84％が腸管で吸収され、60～90分後に最高血漿中濃度に達する。脂肪分の多い食事と一緒に摂取した場合、フェブキソスタットの体内濃度は低くなるが、これは臨床的な意義はないと考えられている。血中では、物質の99.2％が血漿タンパク質アルブミンと結合し...")
20:35, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/14/ja (Created page with "== 薬理学{{Anchor|Pharmacology}} == === 作用機序=== フェブキソスタットはキサンチンオキシダーゼの非プリン選択的阻害薬である。キサンチンオキシダーゼの活性部位であるモリブデンプテリン中心を非競合的阻害することで作用する。キサンチンオキシダーゼは、ヒポキサンチンと[...")
20:33, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/13/ja (Created page with "==薬物相互作用{{Anchor|Drug interactions}}== フェブキソスタットは、テオフィリンおよび化学療法薬、すなわちアザチオプリンおよび6-メルカプトプリンとの併用禁忌である。")
20:32, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/12/ja (Created page with "2017年11月、FDAは、安全性臨床試験の予備的結果において、心血管疾患の既往歴のある患者において、アロプリノールと比較してフェブキソスタットで心臓関連死のリスクが増加したことを示す安全性警告を発した。FDAは2009年にこの薬が承認された際、武田薬品にこの安全性試験の実施を要求した。承認前に実施された臨床試験では、フ...")
20:31, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/11/ja (Created page with "==副作用{{Anchor|Side effects}}== フェブキソスタット治療に伴う副作用には、吐き気、下痢、関節痛、頭痛、肝血清酵素値の上昇、発疹などがある。")
20:31, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/10/ja (Created page with "==医薬用途{{Anchor|Medical uses}}== フェブキソスタットは、慢性痛風および高尿酸血症の治療に用いられる。フェブキソスタットは通常、アロプリノールに耐えられない人にのみ推奨される。米国国立医療技術評価機構は、フェブキソスタットは標準用量のアロプリノールよ...")
20:29, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/20/ja (Created page with "米国でジェネリック医薬品になる前の2010年には、アロプリノールが1ヵ月あたり約14ドルだったのに対し、この薬は1ヵ月あたり約{{US$|160}}だった。")
20:29, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/19/ja (Created page with "== 社会と文化{{Anchor|Society and culture}} == === 経済学=== 英国では、NICEはフェブキソスタットの方がアロプリノールよりも費用対便益比が高いと判断し、その上でフェブキソスタットをアロプリノールを使用できない人の第二選択薬として推奨している。")
20:26, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/21/ja (Created page with "===商品名=== Febuxostatは、欧州、オーストラリア、ニュージーランド、パキスタンではAdenuricとして販売されている。パキスタンではSJGの姉妹会社であるSOLACE Pharmaceuticals社によって販売されている。米国ではUloric、中南米ではGoturic、Goutex、日本ではFeburic、エジプトではDonifoxateとして発売している。")
20:25, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/22/ja (Created page with "{{Antigout preparations/ja}} {{Purinergics/ja}} {{Portal bar | Medicine}}")
20:24, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/23/ja (Created page with "Category:Antigout agents Category:Xanthine oxidase inhibitors Category:Thiazoles Category:Drugs developed by Takeda Pharmaceutical Company Category:Carboxylic acids Category:Nitriles Category:Phenol ethers")
20:24, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/9/ja (Created page with " フェブキソスタットはEUでは2008年に、米国では2009年に医薬品として承認されている。")
20:24, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/8/ja (Created page with " 一般的な副作用には、肝障害、吐き気、関節痛、発疹などがある。重篤な副作用としては、アロプリノールと比較して死亡リスクが高まること、スティーブンス・ジョンソン症候群、アナフィラキシーなどがある。妊娠中や授乳中の使用は推奨されない。xant...")
20:23, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/7/ja (Created page with " '''フェブキソスタット'''（'''Febuxostat'''）は、高尿酸値による痛風の治療に長期的に使用される医薬品である。一般に、アロプリノールを服用できない人にのみ推奨される。開始当初は、痛風の再燃を防ぐためにNSAIDsなどの医薬品がしばしば推奨される。by mouth/ja|...")
20:21, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/6/ja (Created page with " | IUPAC_name = 2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acid | C=16 | H=16 | N=2 | Na= | O=3 | S=1 | smiles = N#Cc1c(OCC(C)C)ccc(c1)c2nc(c(s2)C(=O)O)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = BQSJTQLCZDPROO-UHFFFAOYS...")
20:21, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/5/ja (Created page with " | IUPHAR_ligand = 6817 | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 144060-53-7 | PubChem = 134018 | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = DB04854 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 118173 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 101V0R1N2E | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D01206 | ChEBI = 31596 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1164729")
20:21, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/4/ja (Created page with " | bioavailability = ≥84% absorbed | protein_bound = 99.2% to albumin | metabolism = via CYP1A1/ja, 1A2, 2C8, 2C9, UGT1A1/ja, 1A8, 1A9 | elimination_half-life = ~5–8 hours | excretion = 尿（～49％、大部分は代謝物として、3％は未変化体として）；糞便（～45％、大部分は代謝物として、12％は未変化体として）")
20:20, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/3/ja (Created page with "| legal_AU = S4 | legal_AU_comment = | legal_CA =  | legal_UK =  | legal_US = Rx-only | legal_EU = Rx-only | legal_status =")
20:20, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/2/ja (Created page with " | tradename = Uloric, Adenuric, others | Drugs.com = {{drugs.com|monograph|febuxostat}} | MedlinePlus = a609020 | licence_EU = yes | DailyMedID = Febuxostat | licence_US = Febuxostat | pregnancy_AU = B1 | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = 経口 | ATC_prefix = M04 | ATC_suffix = AA03 | ATC_supplemental =")
20:20, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/1/ja (Created page with "{{Drugbox | Verifiedfields = changed | verifiedrevid = 459437484 | image = Febuxostat.svg | alt =")
20:20, 22 April 2024 Fire talk contribs created page Febuxostat/ja (Created page with "フェブキソスタット") Tags: Mobile edit Mobile web edit
20:20, 22 April 2024 Fire talk contribs created page Translations:Febuxostat/Page display title/ja (Created page with "フェブキソスタット")
20:19, 22 April 2024 Fire talk contribs marked Febuxostat for translation
20:19, 22 April 2024 Fire talk contribs limited languages for translatable page Febuxostat to Japanese
20:18, 22 April 2024 Fire talk contribs created page Category:Phenol ethers (Created page with "{{Commons category}} {{cat main|Phenol ether}} {{Distinguish|Category:Phenol esters}} This category includes chemical compounds that are '''ethers''' of '''phenols'''. Phenols include phenol (C6H5OH), benzenediol etc., and polyphenols, with and without substituents. {{Category diffuse}} {{CatAutoTOC}} Category:Aromatic ethers Category:Phenyl compounds")
20:18, 22 April 2024 Fire talk contribs created page Category:Drugs developed by Takeda Pharmaceutical Company (Created page with "{{Commonscat}} {{Cat main|Takeda Pharmaceutical Company}} Category:Brands by company Category:Drug brand names Category:Health care brands Brands")