Main public logs
Combined display of all available logs of Azupedia. You can narrow down the view by selecting a log type, the username (case-sensitive), or the affected page (also case-sensitive).
- 18:59, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/21/ja (Created page with "== 作用機序 == {{Anchor|Mechanism of action}} フォリン酸はテトラヒドロ葉酸の5-ホルミル誘導体である。他の還元型葉酸誘導体（5,10-メチレンテトラヒドロ葉酸、5-メチルテトラヒドロ葉酸など）に容易に変換されるため、葉酸と同等のビタミン活性を有する。その変換にはdihydrofolate reduc...")
- 18:58, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/20/ja (Created page with "スルファメトキサゾール-トリメトプリム： スルファメトキサゾール-トリメトプリムとフォリン酸の併用には潜在的な薬物相互作用が存在する。フォリン酸は、AIDS患者の肺炎の一般的な原因である''ニューモシスチス・ジロベシイ''（旧称'''ニューモシスチス・カリニイ'''）の治療におけるスルファメト...")
- 18:57, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/19/ja (Created page with "== 薬物相互作用 == {{Anchor|Drug interactions}} フルオロウラシル： この2つを一緒に投与すると、コリン酸はフルオロウラシルに関連する毒性を増大させることがある。特に高齢の患者で発生した副作用には、重度の腸炎、下痢、脱水がある。")
- 18:56, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/18/ja (Created page with "がん患者では、まれにフォリン酸に対する過敏症反応が報告されている。")
- 18:56, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/17/ja (Created page with "== 副作用 == フォリン酸は髄腔内投与すべきではない。重篤な副作用を引き起こす可能性があり、死に至ることもある。")
- 18:55, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/25/ja (Created page with "== 歴史 == {{Anchor|History}} フォリン酸は、1948年にザウバーリッヒとバウマンによって、細菌''Leuconostoc citrovorum''に必要な増殖因子として発見された。その結果、シトロボルム増殖因子を意味する「シトロボルム因子」と呼ばれるようになった。シトロボルム因子は未知の構造を持つが、葉酸の誘導体であり、肝臓で代謝されなければ''...")
- 18:18, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/16/ja (Created page with "ピリドキシン依存性てんかんでは、ピリドキシンまたはピリドキサールリン酸が発作を完全に制御できない場合、追加療法としてフォリン酸が使用されることがある。")
- 18:18, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/15/ja (Created page with "また、葉酸を使用しても5-MTHFの脳脊髄液レベルを正常化できない症候群である脳性葉酸欠乏症の治療にも用いられる。")
- 18:17, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/14/ja (Created page with "また、トリメトプリムやピリメタミンなどの抗菌薬ジヒドロ葉酸還元酵素阻害薬の高用量投与による毒性作用を防ぐために、コリン酸が使用されることもあるが、この適応に対する価値は明確に確立されていない。 葉酸拮抗薬であるピリメタミンやスルファジアジンとの併用...")
- 18:15, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/13/ja (Created page with "フォリン酸はまた、結腸がんの治療において化学療法剤5-フルオロウラシルと併用される。この場合、フォリン酸は「救済」目的で使用されるのではなく、むしろチミジル酸合成酵素を阻害することによって5-フルオロウラシルの効果を増強する。")
- 18:15, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/12/ja (Created page with "さらに、フォリン酸は関節リウマチ患者におけるメトトレキサートの副作用を軽減するために用いられることもある。これには、吐き気、腹痛、肝血液検査異常、口内炎の軽減が含まれる。")
- 18:14, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/11/ja (Created page with "特にメトトレキサートの解毒剤ではないが、フォリン酸は急性メトトレキサート過量投与の治療にも有用である。さまざまな投与プロトコールが用いられるが、メトトレキサート濃度が5×10<sup>-8</sup> M未満になるまで、フォリン酸を再投与すべきである。")
- 18:14, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/10/ja (Created page with "== 医療用途 == {{Anchor|Medical use}} thumb|レボフォリン酸 フォリン酸は、骨髄抑制または消化管粘膜の炎症から保護する可能性があり、総化学療法計画の一部としてメトトレキサートに続いて投与される。既存のメトトレキサート誘発性の腎毒性に対する明らかな効果はみられない...")
- 18:12, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/9/ja (Created page with "<!-- History and culture --> フォリニック酸は1945年に初めて製造された。世界保健機関の必須医薬品リストに掲載されている。")
- 18:12, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/8/ja (Created page with "<!-- Side effects and mechanism --> 副作用には、睡眠障害、アレルギー反応、または発熱が含まれることがある。妊娠中または授乳中の使用は一般的に安全とみなされている。貧血に使用する場合は、まず原因として悪性貧血を除外することが推奨される。コリン酸はdihydrofolate reductase...")
- 18:10, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/27/ja (Created page with "一般に、カルシウム塩またはナトリウム塩として投与される（フォリナートカルシウム（INN）、フォリナートナトリウム、ロイコボリンカルシウム、ロイコボリンナトリウム）。")
- 18:10, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/26/ja (Created page with "==名称== フォリン酸は葉酸（ビタミンB<sub>9</sub>）と区別されるべきである。しかし、フォリン酸は葉酸のビタマーであり、このビタミンの完全なビタミン活性を持つ。レボホリニック酸とその塩は分子の2S形である。これらは、生物学的に活性であることが知られている分子の唯一の形態である。")
- 18:02, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/28/ja (Created page with "== 外部リンク == * {{cite web | title=Leucovorin | website=MedlinePlus | url=https://medlineplus.gov/druginfo/meds/a682336.html }}")
- 18:02, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/29/ja (Created page with "{{Detoxifying agents for antineoplastic treatment/ja}} {{Vitamin/ja}} {{Portal bar|Medicine}}")
- 18:02, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/30/ja (Created page with "Category:Chemotherapeutic adjuvants Category:Folates Category:World Health Organization essential medicines Category:Wikipedia medicine articles ready to translate")
- 18:01, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/7/ja (Created page with "<!-- Definition and medical uses --> '''ロイコボリン'''としても知られる'''フォリン酸'''は、メトトレキサートとピリメタミンの毒性作用を低下させるために用いられる医薬品である。また、大腸がんや膵臓がんの治療に5-フルオロウラシルと併用されたり、貧血を引き起こすfolate deficie...")
- 17:59, 5 April 2024 Fire talk contribs created page Folinic acid/ja (Created page with "{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470454241 | image = Folinic acid.svg | alt = フォリン酸の骨格式 | width = 250 | image2 = Leucovorin molecule ball.png | alt2 = フォリン酸分子のボール＆スティック・モデル")
- 17:59, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/6/ja (Created page with "<!--Chemical data--> | IUPAC_name = (''2S'')-2-<nowiki/>{[4-[(2-amino-5-formyl-4-oxo-5,6,7,8-<br />tetrahydro-1''H''-pteridin-6-yl)methylamino]<br />benzoyl]amino}pentanedioic acid | C=20 | H=23 | N=7 | O=7 | SMILES = O=C(O)[C@@H](NC(=O)c1ccc(cc1)NCC3N(/C2=C(/N/C(=N\C2=O)N)NC3)C=O)CCC(=O)O | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h...")
- 17:59, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/5/ja (Created page with "<!--Identifiers--> | IUPHAR_ligand = 4816 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 1492-18-8 | PubChem = 6006 | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = DB00650 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 5784 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = RPR1R4C0P4 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1679 | synonyms = citrovorum factor, 5-formyltetrahydrofolate")
- 17:58, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/4/ja (Created page with "<!-- Pharmacokinetic data --> | bioavailability = Dose dependent | protein_bound = ~15% | metabolism = | elimination_half-life = 6.2 hours | excretion = Kidney/ja")
- 17:58, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/3/ja (Created page with "<!-- Legal status --> | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> | legal_AU_comment = | legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> | legal_BR_comment = | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA_comment = | legal_DE = <!-- Anlage I, II, III or Unscheduled --> | legal_DE_comment = | legal_NZ = <!-- Class A, B, C --> | legal_NZ_comment = | legal_UK = <!-- GSL, P, POM,...")
- 17:58, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/2/ja (Created page with "<!--Clinical data--> | pronounce = Leucovorin {{IPAc-en|ˌ|lj|uː|k|oʊ|ˈ|v|ɔː|r|ɪ|n}} | tradename = Many | Drugs.com = {{drugs.com|monograph|leucovorin-calcium}} | MedlinePlus = a608038 | DailyMedID = Leucovorin calcium | pregnancy_AU = A | routes_of_administration = 静脈内注射, IM, 口から | ATC_prefix = V03 | ATC_suffix = AF03")
- 17:58, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/1/ja (Created page with "{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470454241 | image = Folinic acid.svg | alt = フォリン酸の骨格式 | width = 250 | image2 = Leucovorin molecule ball.png | alt2 = フォリン酸分子のボール＆スティック・モデル")
- 17:57, 5 April 2024 Fire talk contribs created page Translations:Folinic acid/Page display title/ja (Created page with "フォリン酸")
- 17:57, 5 April 2024 Fire talk contribs marked Folinic acid for translation
- 17:57, 5 April 2024 Fire talk contribs limited languages for translatable page Folinic acid to Japanese
- 17:55, 5 April 2024 Fire talk contribs created page Category:Chemotherapeutic adjuvants (Created page with "{{Detoxifying agents for antineoplastic treatment|state=collapsed}} {{Commons cat|Chemotherapeutic adjuvants}} {{Cat main|Adjuvant therapy}} Category:Antineoplastic drugs")
- 17:52, 5 April 2024 Fire talk contribs created page 5-formyltetrahydrofolate transport (Q21793) (wbeditentity-create:2|en: 5-formyltetrahydrofolate transport, The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore.)
- 17:51, 5 April 2024 Fire talk contribs created page 5-formyltetrahydrofolate transmembrane transporter activity (Q21792) (wbeditentity-create:2|en: 5-formyltetrahydrofolate transmembrane transporter activity, Enables the directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells.)
- 17:49, 5 April 2024 Fire talk contribs created page lactam (Q21791) (wbeditentity-create:2|en: lactam, class of chemical compounds)
- 17:47, 5 April 2024 Fire talk contribs created page benzamide (Q21790) (wbeditentity-create:2|en: benzamide, any chemical compound with benzamido group)
- 17:45, 5 April 2024 Fire talk contribs created page folinic acid (Q21789) (wbeditentity-create:2|en: folinic acid, group of stereoisomers)
- 17:42, 5 April 2024 Fire talk contribs created page Template:Detoxifying agents for antineoplastic treatment/ja (Created page with "{{Navbox | name = Detoxifying agents for antineoplastic treatment/ja | title = 化学療法治療におけるデトックス (V03AF) | state = {{{state<includeonly>|autocollapse</includeonly>}}} | listclass = hlist | group1 = Folic acid/ja / methotrexate/ja | list1 = * フォリン酸の塩 ** 葉酸カルシウム／レボホリナートカルシウム ** 葉酸ナト...")
- 17:37, 5 April 2024 Fire talk contribs created page Template:Detoxifying agents for antineoplastic treatment (Created page with "{{Navbox | name = Detoxifying agents for antineoplastic treatment | title = Detoxifying agents for chemotherapy treatment (V03AF) | state = {{{state<includeonly>|autocollapse</includeonly>}}} | listclass = hlist | group1 = Folic acid / methotrexate | list1 = * Salts of Folinic acid ** calcium folinate/calcium levofolinate ** sodium folinate/sodium levofolinate | group2 = Uric acid (Tumor lysis syndr...")
- 17:37, 5 April 2024 Fire talk contribs created page Folinic acid (Created page with "{{Short description|Derivative of folic acid used in cancer treatment}} {{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470454241 | image = Folinic acid.svg | alt = Skeletal formula of folinic acid | width = 250 | image2 = Leucovorin molecule ball.png | alt2 = Ball-and-stick model of the folinic acid molecule <!--Clinical data--> | pronounce = Leucovorin {{IPAc-en|ˌ|lj|uː|k|oʊ|ˈ|v|ɔː|r|ɪ|n}} | tradename = Many | Drugs.com = {{dr...")
- 16:24, 5 April 2024 Fire talk contribs created page Translations:Dihydrofolic acid/9/ja (Created page with "Category:EC 6.3.2 Category:Enzymes of known structure")
- 16:24, 5 April 2024 Fire talk contribs created page Translations:Dihydrofolic acid/8/ja (Created page with "{{Ligases CO CS and CN/ja}} {{Enzymes/ja}} {{Portal bar|Biology|border=no}}")
- 16:24, 5 April 2024 Fire talk contribs created page Translations:Dihydrofolic acid/7/ja (Created page with "==参照== * {{cite journal | vauthors = GRIFFIN MJ, BROWN GM | title = The Biosynthesis of Folic Acid. III. Enzymatic Formation of Dihydrofolic Acid from Dihydropteroic Acid and of Tetrahydropteroylpolyglutamic Acid Compounds from Tetrahydrofolic Acid | date = 1964 | journal = J. Biol. Chem. | volume = 239 | pages = 310–6 | doi = 10.1016/S0021-9258(18)51783-X | pmid = 14114858 | doi-access = free }} * {{cite journal | vauthors = Bognar AL, Osborne C, Shane B, Si...")
- 16:23, 5 April 2024 Fire talk contribs created page Translations:Dihydrofolic acid/6/ja (Created page with "2007年末現在、このクラスの酵素については3つの構造が解明されており、PDBのアクセッションコードは{{PDB link|1W78}}、{{PDB link|1W7K}}、{{PDB link|2BMB}}である。")
- 16:23, 5 April 2024 Fire talk contribs created page Translations:Dihydrofolic acid/5/ja (Created page with "==構造研究== {{Anchor|Structural studies}}")
- 16:23, 5 April 2024 Fire talk contribs created page Translations:Dihydrofolic acid/4/ja (Created page with "この酵素はリガーゼのファミリーに属し、特に酸-D-アミノ酸リガーゼ（ペプチド合成酵素）として炭素-窒素結合を形成する。 この酵素クラスの|系統名は'''7,8-ジヒドロテロエート:L-グルタミン酸リガーゼ（ADP形成）'''である。その他の一般的な名称としては、'''ジヒドロ葉酸合成酵素'''、'''7,8-ジヒドロ葉酸合成酵素'''、'''H2-...")
- 16:20, 5 April 2024 Fire talk contribs created page Translations:Dihydrofolic acid/3/ja (Created page with "この酵素の3つの基質はATP、7,8-ジヒドロテロエート、L-グルタミン酸であり、3つの産物はADP、リン酸、7,8-ジヒドロテロイルグルタミン酸である。")
- 16:18, 5 April 2024 Fire talk contribs created page Translations:Dihydrofolic acid/2/ja (Created page with ":ATP + 7,8-dihydropteroate + L-glutamate <math>\rightleftharpoons</math> ADP + phosphate + 7,8-dihydropteroylglutamate")
- 16:18, 5 April 2024 Fire talk contribs created page Translations:Dihydrofolic acid/1/ja (Created page with "{{infobox enzyme | Name = ジヒドロ葉酸合成酵素 | EC_number = 6.3.2.12 | CAS_number = 37318-62-0 | GO_code = 0008841 | image = 1w7k.jpg | width = 270 | caption = ジヒドロ葉酸合成酵素モノマー, 大腸菌 }} 酵素学において、'''ジヒドロ葉酸合成酵素'''（{{EnzExplorer|6.3.2.12}}）は、化学反応を触媒する酵素である。")
- 16:18, 5 April 2024 Fire talk contribs created page Dihydrofolic acid/ja (Created page with "ジヒドロ葉酸合成酵素")
