Main public logs
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- 13:52, 5 April 2024 Fire talk contribs created page Translations:Folate/68/ja (Created page with "== 外部リンク ==")
- 13:52, 5 April 2024 Fire talk contribs created page Translations:Folate/69/ja (Created page with ";生化学リンク *[https://web.archive.org/web/20030729120709/http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/misc/folate1.html Folate biosynthesis (early stages)] *[https://web.archive.org/web/20170806041915/http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/misc/folate2.html Folate biosynthesis (later stages)] *[https://web.archive.org/web/20031111105125/http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/misc/folate3.html Folate coenzymes] *[https://web.archive.org/web...")
- 13:52, 5 April 2024 Fire talk contribs created page Translations:Folate/70/ja (Created page with "{{ATC navboxes/ja|B03|V04}}{{Vitamins/ja}}{{Dietary supplement/ja}} {{Portal bar|Medicine}}")
- 13:51, 5 April 2024 Fire talk contribs created page Translations:Folate/71/ja (Created page with "{{DEFAULTSORT:Folic Acid}} Category:B vitamins Category:Dicarboxylic acids Category:World Health Organization essential medicines Category:Wikipedia medicine articles ready to translate")
- 13:51, 5 April 2024 Fire talk contribs created page Translations:Folate/7/ja (Created page with "<!-- Definition and uses --> '''葉酸'''は、'''ビタミンB<sub>9</sub>'''や'''フォラシン'''とも呼ばれ、ビタミンB群の1つである。体内で葉酸に変換される製造された'''葉酸'''は、加工時や保存時に安定性が高いため、栄養補助食品や食品強化に用いられる。葉酸は、体内でDNAとRNAを作り、cell division...")
- 13:49, 5 April 2024 Fire talk contribs created page Translations:Folate/6/ja (Created page with "<!-- Chemical and physical data --> | IUPAC_name = (2''S'')-2-<nowiki>[[</nowiki>4-[(2-Amino-4-oxo-1''H''-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid | C = 19 | H = 19 | N = 7 | O = 6 | SMILES = n1c2C(=O)NC(N)=Nc2ncc1CNc3ccc(cc3)C(=O)N[C@H](C(O)=O)CCC(O)=O | StdInChI = 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 |...")
- 13:49, 5 April 2024 Fire talk contribs created page Translations:Folate/5/ja (Created page with "<!-- Identifiers --> | index2_label = as salt | CAS_number = 59-30-3 | CAS_number2 = 6484-89-5 | CAS_supplemental = | PubChem = 6037 | IUPHAR_ligand = 4563 | DrugBank = DB00158 | DrugBank2 = DBSALT001918 | ChemSpiderID = 5815 | ChemSpiderID2 = 21512 | UNII = 935E97BOY8 | UNII2 = 9P9W8GGU78 | KEGG = D00070 | KEGG2 = D07985 | ChEBI = 27470 | ChEMBL = 1622 | NIAID_ChemDB = | PDB_ligand = FOL | synonyms = Wills factor, FA, ''N''-(4-<nowiki/>{[(2-amino-4-oxo-1,4-dihydropter...")
- 13:49, 5 April 2024 Fire talk contribs created page Translations:Folate/4/ja (Created page with "<!-- Pharmacokinetic data --> | bioavailability = 50–100% | protein_bound = | metabolism = Liver/ja | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion = Urine")
- 13:49, 5 April 2024 Fire talk contribs created page Translations:Folate/3/ja (Created page with "<!-- Legal status --> | legal_AU = S4 | legal_AU_comment = / S2 | legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> | legal_BR_comment = | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA_comment = | legal_DE = <!-- Anlage I, II, III or Unscheduled --> | legal_DE_comment = | legal_NZ = <!-- Class A, B, C --> | legal_NZ_comment = | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD...")
- 13:49, 5 April 2024 Fire talk contribs created page Translations:Folate/2/ja (Created page with "<!-- Clinical data --> | pronounce = {{IPAc-en|ˈ|f|oʊ|l|ɪ|k|,_|ˈ|f|ɒ|l|ɪ|k}} | tradename = Folicet, Folvite | Drugs.com = {{drugs.com|monograph|folic-acid}} | MedlinePlus = a682591 | DailyMedID = Folic acid | pregnancy_AU = A | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = 口から, 筋肉内, 静脈内, 皮下 | class =...")
- 13:48, 5 April 2024 Fire talk contribs created page Translations:Folate/1/ja (Created page with "{{Infobox drug | drug_name = Folic acid | image = Folic acid.svg | width = 260 | alt = 骨格式 | caption = | image2 = Folic-acid-from-xtal-3D-bs-17.png | width2 = 280 | alt2 =")
- 13:48, 5 April 2024 Fire talk contribs created page Folate/ja (Created page with "葉酸")
- 13:48, 5 April 2024 Fire talk contribs created page Translations:Folate/Page display title/ja (Created page with "葉酸")
- 13:48, 5 April 2024 Fire talk contribs marked Folate for translation
- 13:48, 5 April 2024 Fire talk contribs limited languages for translatable page Folate to Japanese
- 13:46, 5 April 2024 Fire talk contribs created page Category:Dicarboxylic acids (Created page with "{{Cat main|dicarboxylic acid}} {{Commons cat|Dicarboxylic acids}} Category:Carboxylic acids")
- 13:46, 5 April 2024 Fire talk contribs created page Category:Folates (Created page with "{{Commons category|Folate}} '''Folates''' are derivatives of folic acid. For folate-analogue drugs see antifolates. Category:Pteridines Category:Amines Category:Amides Category:Glutamates")
- 13:44, 5 April 2024 Fire talk contribs created page Module:ATC code to template name/ja (Created page with "-- this module provides a lookup from ATC codes to their associated navbox templates -- local data = mw.loadData("Module:ATC code to template name/data/ja") p = {} function p.translate(frame) local name = frame.args[1] for _, v in pairs(data) do if v.code == name then if v.template then return frame:expandTemplate{ title = v.template } else error("ATC code not specific enough - please use one further character (example: instead of M01, use M01A)")...")
- 13:43, 5 April 2024 Fire talk contribs created page Module:ATC code to template name/data/ja (Created page with "return { { code="A01", template="Stomatological preparations/ja",}, { code="A02A", template="Antacids/ja", }, { code="A02B", template="Drugs for peptic ulcer and GORD/ja", }, { code="A03", template="Drugs for functional gastrointestinal disorders/ja", }, { code="A04", template="Antiemetics/ja", }, { code="A05", template="Bile and liver therapy/ja", }, { code="A06", template="Laxatives/ja", }, { code="A07", template="Antidiarrheals, intestinal anti-inflammatory an...")
- 13:39, 5 April 2024 Fire talk contribs created page Template:Antianemic preparations/ja (Created page with "{{Navbox | name = Antianemic preparations/ja | title = 抗血液製剤 (B03) | state = {{{state<includeonly>|autocollapse</includeonly>}}} | listclass = hlist | group1 = Erythropoietin/ja | list1 = * Erythropoietin/ja * Darbepoetin alfa/ja * Methoxy polyethylene glycol-epoetin beta/ja * Peginesatide/ja | group2 = Iron supplement/ja | list2 = * 水酸化鉄 * Fe...")
- 13:34, 5 April 2024 Fire talk contribs created page Template:Diagnostic agents/ja (Created page with "{{Navbox | name = Diagnostic agents/ja | title = 診断エージェント (V04) | state = {{{state|autocollapse}}} | listclass = hlist | groupwidth = 10em | group1 = 消化器系 | list1 = {{Navbox|subgroup | groupwidth = 16em | group1 = 糖尿病 | list1 = * Glucose/ja * Tolbutamide/ja | group2 = 脂肪吸収 | list2 = * Vitamin A/ja|ビタ...")
- 13:27, 5 April 2024 Fire talk contribs created page Template:Diagnostic agents (Created page with "{{Navbox | name = Diagnostic agents | title = Diagnostic agents (V04) | state = {{{state|autocollapse}}} | listclass = hlist | groupwidth = 10em | group1 = Digestive system | list1 = {{Navbox|subgroup | groupwidth = 16em | group1 = Diabetes | list1 = * Glucose * Tolbutamide | group2 = Fat absorption | list2 = * Vitamin A concentrates | group3 = Bile d...")
- 13:26, 5 April 2024 Fire talk contribs created page Template:Antianemic preparations (Created page with "{{Navbox | name = Antianemic preparations | title = Antianemic preparations (B03) | state = {{{state<includeonly>|autocollapse</includeonly>}}} | listclass = hlist | group1 = Erythropoietins | list1 = * Erythropoietin * Darbepoetin alfa * Methoxy polyethylene glycol-epoetin beta * Peginesatide | group2 = Iron supplements | list2 = * Ferric hydroxide * Ferric maltol *...")
- 13:24, 5 April 2024 Fire talk contribs created page Module:ATC code to template name/data (Created page with "return { { code="A01", template="Stomatological preparations",}, { code="A02A", template="Antacids", }, { code="A02B", template="Drugs for peptic ulcer and GORD", }, { code="A03", template="Drugs for functional gastrointestinal disorders", }, { code="A04", template="Antiemetics", }, { code="A05", template="Bile and liver therapy", }, { code="A06", template="Laxatives", }, { code="A07", template="Antidiarrheals, intestinal anti-inflammatory and anti-infective agen...")
- 13:24, 5 April 2024 Fire talk contribs created page Module:ATC code to template name (Created page with "-- this module provides a lookup from ATC codes to their associated navbox templates -- local data = mw.loadData("Module:ATC code to template name/data") p = {} function p.translate(frame) local name = frame.args[1] for _, v in pairs(data) do if v.code == name then if v.template then return frame:expandTemplate{ title = v.template } else error("ATC code not specific enough - please use one further character (example: instead of M01, use M01A)") ret...")
- 13:18, 5 April 2024 Fire talk contribs created page Template:ATC navboxes/ja (Created page with "{{navboxes |title = 解剖学的治療化学分類（ATCコード）による関連薬物 |state = collapsed |list = {{ #if: {{{1|}}} | {{#invoke:ATC code to template name|translate|{{{1}}}}} | No codes given<includeonly>Category:ATC navbox wrappers with no codes</includeonly> }} {{ #if: {{{2|}}} | {{#invoke:ATC code to template name|translate|{{{2}}}}} | }} {{ #if: {{{3|}}} | {{#invoke:ATC code to template name|translate|{{{3}}}}} | }} {{ #if: {{{4|}...")
- 13:17, 5 April 2024 Fire talk contribs created page Template:ATC navboxes (Created page with "{{navboxes |title = Related drugs by Anatomical Therapeutic Chemical classification (ATC code) |state = collapsed |list = {{ #if: {{{1|}}} | {{#invoke:ATC code to template name|translate|{{{1}}}}} | No codes given<includeonly>Category:ATC navbox wrappers with no codes</includeonly> }} {{ #if: {{{2|}}} | {{#invoke:ATC code to template name|translate|{{{2}}}}} | }} {{ #if: {{{3|}}} | {{#invoke:ATC code to template name|translate|{{{3}}}}} | }} {{ #if: {{{4...")
- 13:17, 5 April 2024 Fire talk contribs created page Folate (Created page with "{{Short description|Vitamin B9; nutrient essential for DNA synthesis}} {{Infobox drug | drug_name = Folic acid | image = Folic acid.svg | width = 260 | alt = Skeletal formula | caption = | image2 = Folic-acid-from-xtal-3D-bs-17.png | width2 = 280 | alt2 = <!-- Clinical data --> | pronounce = {{IPAc-en|ˈ|f|oʊ|l|ɪ|k|,_|ˈ|f|ɒ|l|ɪ|k}} | tradename = Folicet, Folvite | Drugs.com = {{drugs.com|monograph|folic-acid}} | MedlinePlus = a682591 | DailyMedID = Folic acid | pr...")
- 12:55, 5 April 2024 Fire talk contribs created page Translations:Biotin/37/ja (Created page with "1994年に制定された栄養補助食品健康教育法では、米国食品医薬品局（FDA）は製品ラベルに「構造：機能」（S:F）と表現される健康強調表示を許可しなければならないと定めている。例えば ビオチンは健康な皮膚、髪、爪の維持を助ける。S:Fを主張する場合、ラベルに「この記述は食品医薬品局（FDA）によっ...")
- 12:54, 5 April 2024 Fire talk contribs created page Translations:Biotin/36/ja (Created page with "===髪、爪、皮膚=== 米国では、ビオチンは毛髪と爪の強化のための栄養補助食品として宣伝されているが、ヒトにおけるこれらの結果を支持する科学的データは非常に弱い。指の爪に関する文献のレビューでは、プラセボ対照の比較群なしに、2.5 mg/日の経口栄養補助食品を数ヶ月間投与した1990年以前の2つの臨床試験...")
- 12:54, 5 April 2024 Fire talk contribs created page Translations:Biotin/35/ja (Created page with "===多発性硬化症=== 脱髄性自己免疫疾患である多発性硬化症の治療に、高用量のビオチン（300 mg/日＝食事摂取基準の10,000倍）が臨床試験で用いられている。その仮説は、ビオチンが神経細胞のミエリン鞘の再髄鞘化を促進し、神経変性を遅らせるか、あるいは逆転させるのではな...")
- 12:53, 5 April 2024 Fire talk contribs created page Translations:Biotin/34/ja (Created page with "==研究== {{Anchor|Research}}")
- 12:52, 5 April 2024 Fire talk contribs created page Translations:Biotin/33/ja (Created page with "''大腸菌''を用いた生合成経路は、1968年にRolfeとEisenbergによって提案された。最初の段階は、ピメリル-CoAとアラニンの縮合で7-オキソ-8-アミノペラルゴン酸が形成されると説明された。そこから3段階の過程を経て、最後に硫黄原子を導入してテトラヒドロチオフェン環を形成すると説明した。")
- 12:52, 5 April 2024 Fire talk contribs created page Translations:Biotin/32/ja (Created page with "1936年、Fritz KöglとBenno Tönnisは、"{{Lang|de|Darstellung von krystallisiertem biotin aus eigelb|italic=no}}（卵黄から結晶化したビオチンの表現）"というタイトルの学術論文で、酵母成長因子を単離したことを記録した。''ビオチン''という名前は、ギリシャ語の{{Transliteration|grc|bios}}('生きる')と接尾辞"-in"(有機化学で使われる一般的な化学接尾辞)に由来する。他の研究グル...")
- 12:49, 5 April 2024 Fire talk contribs created page Translations:Biotin/31/ja (Created page with "==歴史== {{Anchor|History}} {{Further/ja|Vitamin/ja#History}} 1916年、W.G.ベイトマンは、生の卵白を多く含む食事が、犬、猫、ウサギ、そして人間に毒性症状を引き起こすことを観察した。1927年までに、マルガレーテ・ボアスやヘレン・パーソンズといった科学者たちが、"卵白障害 "に関連する症状を実証する実験を行った。彼らは、唯一のタンパク...")
- 12:48, 5 April 2024 Fire talk contribs created page Translations:Biotin/30/ja (Created page with "==医療検査結果への干渉== {{Anchor|Interference with medical laboratory results}} 人々が栄養補助食品に含まれる高レベルのビオチンを摂取している場合、その結果として、ビオチン-ストレプトアビジン技術を使用する|診断血液検査に臨床的に重大な干渉が起こる可能性がある。この方法は、甲状腺ホルモンのような...")
- 12:47, 5 April 2024 Fire talk contribs created page Translations:Biotin/29/ja (Created page with "==バイオテクノロジーにおける利用== {{Anchor|Use in biotechnology}} ビオチンの化学修飾バージョンは、生化学的アッセイのためにタンパク質や非タンパク質化合物を単離するためにバイオテクノロジー産業全体で広く使用されている。卵由来のアビジンはビオチンと解離定数''K''<sub>d</sub>≈10<sup>-15</sup>&...")
- 12:45, 5 April 2024 Fire talk contribs created page Translations:Biotin/28/ja (Created page with "これらの代謝異常の生化学的および臨床症状には、ケト乳酸アシドーシス、有機酸尿、高アンモニア血症、発疹、筋緊張低下、痙攣、発達遅延、脱毛症、昏睡が含まれる。")
- 12:44, 5 April 2024 Fire talk contribs created page Translations:Biotin/27/ja (Created page with "ビオチン依存性カルボキシラーゼの活性欠損を特徴とする遺伝性代謝異常症は多発性カルボキシラーゼ欠損症と呼ばれる。これらには酵素ホロカルボキシラーゼ合成酵素の欠損が含まれる。ホロカルボキシラーゼ合成酵素欠損症は、体内の細胞がビオチンを効果的に...")
- 12:44, 5 April 2024 Fire talk contribs created page Translations:Biotin/26/ja (Created page with "重度のビオチニダーゼ欠損症は、血清酵素活性が正常値の10％未満と定義され、7.1nmol/min/mLと報告されている。発症率は40,000人から60,000人に1人であるが、近親婚（2番目のいとこまたはそれに近い親族）の多い国では10,000人に1人という高率である。部分的ビオチニダーゼ欠乏症は、血清活性が正常の10％から30％と定義されている。発生率のデータは、政...")
- 12:43, 5 April 2024 Fire talk contribs created page Translations:Biotin/25/ja (Created page with "===代謝異常の結果としての欠乏症=== ビオチニダーゼ欠損症は、ビオチンを再利用する酵素の欠損症であり、遺伝的変異の結果である。ビオチニダーゼは、ビオシチンとビオチニルペプチド（各ホロカルボキシラーゼのタンパク質分解産物）からのビオチンの切断を触媒し、それによってビオチンを再利用する。また、食事中のタン...")
- 12:43, 5 April 2024 Fire talk contribs created page Translations:Biotin/24/ja (Created page with "===診断=== 血清および尿中ビオチンの低下は、ビオチン摂取不足の感度の高い指標ではない。しかし、血清検査は、ビオチンを含む栄養補助食品の摂取の確認や、サプリメントの使用を控える期間が薬物検査の妨げになる可能性を排除するのに十分な期間であるかどうかを確認するのに有用である。間接的な測定は、カルボキシラーゼのビオチン要求量に...")
- 12:42, 5 April 2024 Fire talk contribs created page Translations:Biotin/23/ja (Created page with "食事からの摂取が不十分な場合（まれ）は別として、ビオチン代謝に影響を及ぼす遺伝的疾患によってビオチンの欠乏が引き起こされることがある。これらの中で最も一般的なのはビオチニダーゼ欠損症である。この酵素の活性が低いために、ビオシチンからビオチンをリサイクルすることができない。まれにカルボキ...")
- 12:42, 5 April 2024 Fire talk contribs created page Translations:Biotin/22/ja (Created page with "==欠乏症== {{Anchor|Deficiency}} {{main/ja|Biotin deficiency/ja}} ビオチンは非常に多くの食品に含まれているため、一次的なビオチン欠乏症はまれである。不顕性欠乏症は、髪が薄くなる、爪がもろくなる、皮膚に発疹ができる（典型的には顔にできる）といった軽い症状を引き起こすことがある。")
- 12:41, 5 April 2024 Fire talk contribs created page Translations:Biotin/21/ja (Created page with "核内クロマチンにおけるヒストンタンパク質のビオチン化は、クロマチンの安定性と遺伝子発現に関与する翻訳後修飾である。")
- 12:41, 5 April 2024 Fire talk contribs created page Translations:Biotin/20/ja (Created page with "最初の2つについては、ビオチンは炭酸水素塩をアセチル-CoAに移動させ、脂肪酸合成のためのマロニル-CoAに変換する役割を担う補因子として機能する。PCは糖新生に関与する。MCCはロイシン代謝の一段階を触媒する。PCCはpropionyl-CoA/ja|プロ...")
- 12:38, 5 April 2024 Fire talk contribs created page Translations:Biotin/19/ja (Created page with "==補因子生化学=== 酵素ホロカルボキシラーゼ合成酵素は5つのヒトカルボキシラーゼにビオチンを共有結合させる。酵素にビオチンを共有結合させる： * アセチル-CoAカルボキシラーゼα (ACC1) * アセチル-CoAカルボキシラーゼβ（ACC2） * Pyruvate carboxylase/ja|ピルビ...")
- 12:37, 5 April 2024 Fire talk contribs created page Translations:Biotin/18/ja (Created page with "生合成は2つの前駆体、アラニンとピメロイル-CoAから始まる。これらは7-ケト-8-アミノペラルゴン酸（KAPA）を形成する。KAPAは植物のペルオキシソームからミトコンドリアに運ばれ、そこで酵素BioAの助けを借りて7,8-ジアミノペラルゴン酸（DAPA）に変換される。デチオビオチン合成酵素は、ATPで活性化されたDAPAのカルバメートを...")
- 12:36, 5 April 2024 Fire talk contribs created page Translations:Biotin/17/ja (Created page with "==生合成== {{Anchor|Biosynthesis}} ビオチンは植物体内で合成され、植物の成長と発育に不可欠である。細菌もビオチンを合成しており、大腸に常在する細菌がビオチンを合成し、宿主生物に吸収・利用されると考えられている。")
- 12:36, 5 April 2024 Fire talk contribs created page Translations:Biotin/16/ja (Created page with "===ビオチン必要量に影響する因子==== 慢性的なアルコール使用は、血漿ビオチンの有意な減少と関連している。腸内ビオチン取り込みはまた、抗てんかん薬物カルバマゼピンとプリミドンの効果に敏感であるようである。また、胃部分切除術を受けた患者や他の原因で無胃酸症になっ...")