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Combined display of all available logs of Azupedia. You can narrow down the view by selecting a log type, the username (case-sensitive), or the affected page (also case-sensitive).
- 13:15, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/22/ja (Created page with "NADH1モルが酸化されると、158.2{{nbsp}}kJのエネルギーが放出される。")
- 13:15, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/21/ja (Created page with "NAD<sup>+</sup>は、栄養素と細胞のエネルギー通貨であるアデノシン三リン酸（ATP）との間のエネルギーの相互変換を仲介する電子キャリアとして働く。酸化還元反応において、補酵素の活性部分はニコチンアミドである。NAD<sup>+</sup>では、芳香族ニコチンアミド環の窒素がアデニンジヌクレオチドと共有結合している。窒素上の形式...")
- 13:14, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/20/ja (Created page with "=== 生化学 === thumb|upright=1.3|NAD<sup>+</sup>分子上の活性ニコチンアミド基は、多くの代謝経路で酸化を受ける。 ニコチンアミドは、補酵素ニコチンアミドアデニンジヌクレオチド（NADH / NAD<sup>+</sup>）の一部として、生命維持に不可欠である。細胞内では、ニコチンアミドはNAD<sup>+</sup>とnicotinami...")
- 13:10, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/25/ja (Created page with "== 食品源 == {{Anchor|Food sources}} ナイアシンアミドは、主に肉類、魚類、ナッツ類、キノコ類に微量に含まれる。ナイアシンアミドは、一般的にシリアルなどに添加されている。多くのマルチビタミンには20～30{{nbsp}}mgのビタミンB<sub>3</sub>が含まれており、より高用量のものもある。")
- 13:10, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/19/ja (Created page with "===工業生産=== ニコチノニトリルの加水分解は、''ロドコッカス''J1由来の酵素ニトリルヒドラターゼによって触媒される。動物飼料用に年間3500トンのニコチンアミドが生産される。この酵素により、アミドからニコチン酸へのさらなる加水分解が避けられるため、より選択的な合...")
- 13:08, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/18/ja (Created page with "ニコチノニトリルからは五酸化リンとの反応によって、3-アミノピリジンからは臭素と水酸化ナトリウムから''その場で''調製した次亜臭素酸ナトリウムの溶液との反応によって得られる。 File:Nicotinamide highlighted in NAD+.svg|thumb|right|NAD<sup>+</sup> は、[[nic...")
- 13:06, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/17/ja (Created page with ":500px")
- 13:06, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/16/ja (Created page with "== 化学 == {{Anchor|Chemistry}} ニコチンアミドの構造は、ピリジン環に一級アミド基が''メタ''位に結合したものである。ニコチン酸のアミドである。芳香族化合物であるため、求電子芳香族置換反応を起こし、2つのfunctional group/...")
- 13:03, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/15/ja (Created page with "== 副作用 == {{Anchor|Side effects}} ナイアシンアミドは副作用が少ない。3g/日を超える超高用量では、急性肝毒性が少なくとも1例記録されている。通常量は妊娠中にも安全である。")
- 13:03, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/14/ja (Created page with "=== 皮膚がん === ナイアシンアミドは1日500～1000{{nbsp}}mgの用量で、メラノーマ以外の皮膚がんのリスクが高い人のリスクを低下させる。")
- 13:03, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/13/ja (Created page with "ナイアシンアミドは、試験管内ではヒトケラチノサイトにおけるセラミドの生合成を増加させ、生体内では表皮透過性バリアを改善する。2％と4週間のナイアシンアミド局所塗布は、皮脂排泄率の低下に有効であることが判明している。ナイアシンアミドは、''アクネ菌''によるTLR2/ja|トー...")
- 13:01, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/12/ja (Created page with "=== にきび === ナイアシンアミドクリームはにきびの治療薬として用いられる。")
- 13:01, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/11/ja (Created page with "=== ナイアシン欠乏症 === ナイアシンアミドは、ナイアシン欠乏によって引き起こされるペラグラの治療薬として好まれている。")
- 13:00, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/26/ja (Created page with "== 公定書収載状況 == {{Anchor|Compendial status}} * British Pharmacopoeia/ja * Japanese Pharmacopoeia/ja")
- 12:58, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/31/ja (Created page with "研究では、ナイアシンアミドがHIVの治療に一役買う可能性が示唆されている。")
- 12:58, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/30/ja (Created page with "にきび、酒さ、自己免疫性水疱症、老化皮膚、アトピー性皮膚炎の治療にナイアシンアミドの役割が期待できるという暫定的な証拠がある。ナイアシンアミドはまた、放射線や化学療法によって誘発されたDNA鎖切断の再結合に関与する酵素であるポリ（ADP-リボース）ポリメラーゼ（PARP-1）を阻害する。ARCON（加速放射線療法＋カル...")
- 12:57, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/29/ja (Created page with "ナイアシンアミドは乾癬の治療に有効かもしれない。")
- 12:57, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/28/ja (Created page with "ナイアシンアミドは、水疱性類天疱瘡非メラノーマ皮膚がんの治療など、さらに多くの疾患に対して研究されている。")
- 12:57, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/27/ja (Created page with "== 研究 == {{Anchor|Research}} 2015年の試験で、ナイアシンアミドは非黒色腫皮膚癌と光線性角化症の新規発生率を減少させることが明らかになった。")
- 12:56, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/32/ja (Created page with "{{Vitamins/ja}} {{Estrogen receptor modulators/ja}} {{GABAAR PAMs/ja}} {{HDAC inhibitors/ja}} {{Portal bar|Medicine}}")
- 12:56, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/33/ja (Created page with " Category:B vitamins Category:CYP2D6 inhibitors Category:CYP3A4 inhibitors Category:GABAA receptor positive allosteric modulators Category:GPER agonists Category:World Health Organization essential medicines Category:Wikipedia medicine articles ready to translate")
- 12:56, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/10/ja (Created page with "== 医療用途 == {{Anchor|Medical uses}}")
- 12:56, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/9/ja (Created page with "<!-- History and culture --> ナイアシンアミドは1935年から1937年にかけて発見された。世界保健機関の必須医薬品リストに掲載されている。ナイアシンアミドはジェネリック医薬品および市販薬として入手可能である。商業的には、ナイアシンアミドはニコチン酸（ナイ...")
- 12:54, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/8/ja (Created page with "<!-- Side effects and mechanism --> 副作用はほとんどない。高用量では肝障害が起こることがある。通常量は妊娠中の使用にも安全である。ナイアシンアミドはビタミンB系列の医薬品、特にビタミンB<sub>3</sub>複合体に属する。ニコチン酸のアミドである。ナイアシンアミドを含む食品には、...")
- 11:52, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/7/ja (Created page with "<!-- Definition and medical uses --> ナイアシンアミド（'''Niacinamide'''）または'''ニコチンアミド'''（'''nicotinamide'''）は、食品に含まれるビタミンB<sub>3</sub>の一種であり、栄養補助食品や医薬品として用いられる。サプリメントとしては、ペラグラ（ナイアシン欠乏症）を予防・治療するために経口で使用される。この...")
- 11:50, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/6/ja (Created page with "<!-- Chemical and physical data --> | IUPAC_name = pyridine-3-carboxamide | C = 6 | H = 6 | N = 2 | O = 1 | SMILES = c1cc(cnc1)C(=O)N | StdInChI = 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | StdInChIKey = DFPAKSUCGFBDDF-UHFFFAOYSA-N | density = 1.40 g/cm<sup>3</sup> | density_notes = | melting_point = 129.5 | melting_high = | melting_...")
- 11:50, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/5/ja (Created page with "<!-- Identifiers --> | CAS_number = 98-92-0 | CAS_supplemental = {{cascite|correct|CAS}} | PubChem = 936 | IUPHAR_ligand = | DrugBank = DB02701 | ChemSpiderID = 911 | UNII = 25X51I8RD4 | KEGG = D00036 | ChEBI = 17154 | ChEMBL = 1140 | NIAID_ChemDB = | synonyms = NAM, 3-pyridinecarboxamide<br />niacinamide<br />nicotinic acid amide<br />vitamin PP<br />nicotini...")
- 11:50, 3 April 2024 Fire talk contribs created page Nicotinamide/ja (Created page with "| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_AU_comment = | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA_comment = | legal_DE = <!-- Anlage I, II, III or Unscheduled--> | legal_DE_comment = | legal_NZ = <!-- Class A, B, C --> | legal_NZ_comment = | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM...")
- 11:49, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/4/ja (Created page with "<!-- Pharmacokinetic data --> | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion =")
- 11:49, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/3/ja (Created page with "| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_AU_comment = | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA_comment = | legal_DE = <!-- Anlage I, II, III or Unscheduled--> | legal_DE_comment = | legal_NZ = <!-- Class A, B, C --> | legal_NZ_comment = | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM...")
- 11:49, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/2/ja (Created page with "<!-- Clinical data --> | pronounce = {{IPAc-en|ˌ|n|aɪ|ə|ˈ|s|ɪ|n|ə|m|aɪ|d}}, {{IPAc-en|ˌ|n|ɪ|k|ə|ˈ|t|ɪ|n|ə|m|aɪ|d}} | tradename = | Drugs.com = {{Drugs.com|cdi|niacinamide}} | MedlinePlus = | DailyMedID = Niacinamide | pregnancy_AU = <!-- A/B1/B2/B3/C/D/X --> | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth, topical | class =...")
- 11:49, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/1/ja (Created page with "{{Infobox drug | image = Nicotinamid.svg | width = | alt = | image2 = Nicotinamide-from-xtal-2011-Mercury-3D-sf.png | width2 = | alt2 = | caption =")
- 11:49, 3 April 2024 Fire talk contribs created page Translations:Nicotinamide/Page display title/ja (Created page with "ニコチンアミド")
- 11:49, 3 April 2024 Fire talk contribs marked Nicotinamide for translation
- 11:49, 3 April 2024 Fire talk contribs limited languages for translatable page Nicotinamide to Japanese
- 11:48, 3 April 2024 Fire talk contribs created page Category:Nicotinamides (Created page with "{{Commons category|Nicotinamides}} {{Cat main|Nicotinamide}} Category:3-Pyridyl compounds Category:Carboxamides")
- 11:47, 3 April 2024 Fire talk contribs created page Template:Histone deacetylase inhibitors/ja (Created page with "{{Navbox | name = Histone deacetylase inhibitors/ja | title = Histone deacetylase inhibitor/ja | state = {{{state<includeonly>|collapsed</includeonly>}}} | listclass = hlist | bodyclass = hlist | groupstyle = text-align:center; | border = {{{border|}}}<!--for embedding in other navbox templates--> | list1 = * 3,3'-Diindolylmethane/ja <!--* 4SC-202--> * β-ヒドロキシ酪酸 (β-ヒドロキシ酪酸) * [[Abexinostat/ja]...")
- 11:44, 3 April 2024 Fire talk contribs created page Template:Histone deacetylase inhibitors (Created page with "{{Navbox | name = Histone deacetylase inhibitors | title = Histone deacetylase inhibitors | state = {{{state<includeonly>|collapsed</includeonly>}}} | listclass = hlist | bodyclass = hlist | groupstyle = text-align:center; | border = {{{border|}}}<!--for embedding in other navbox templates--> | list1 = * 3,3'-Diindolylmethane <!--* 4SC-202--> * β-Hydroxybutyric acid (β-hydroxybutyrate) * Abexinostat * Acetoacetic acid...")
- 11:44, 3 April 2024 Fire talk contribs created page Template:HDAC inhibitors/ja (Redirected page to Template:Histone deacetylase inhibitors/ja) Tag: New redirect
- 11:43, 3 April 2024 Fire talk contribs created page Template:HDAC inhibitors (Redirected page to Template:Histone deacetylase inhibitors) Tag: New redirect
- 11:43, 3 April 2024 Fire talk contribs created page Template:GABAAR PAMs/ja (Created page with "{{Navbox | name = GABAA receptor positive modulators/ja | title = {{abbr|GABA|γ-Aminobutyric acid/ja }}<sub>A</sub>受容体陽性モジュレーター | listclass = hlist | state = {{{state<includeonly>|collapsed</includeonly>}}} | groupstyle = text-align: center; | group1 = アルコール | list1 = * Brometone/ja * ブタノール * Chloralodol/ja * Chloro...")
- 11:19, 3 April 2024 Fire talk contribs created page Template:GABAAR PAMs (Created page with "{{Navbox | name = GABAA receptor positive modulators | title = {{abbr|GABA|γ-Aminobutyric acid }}<sub>A</sub> receptor positive modulators | listclass = hlist | state = {{{state<includeonly>|collapsed</includeonly>}}} | groupstyle = text-align: center; | group1 = Alcohols | list1 = * Brometone * Butanol * Chloralodol * Chlorobutanol (cloretone) * Alc...")
- 11:18, 3 April 2024 Fire talk contribs created page Nicotinamide (Created page with "<languages /> <translate> {{Short description|Dietary supplement and medication}} {{Infobox drug | image = Nicotinamid.svg | width = | alt = | image2 = Nicotinamide-from-xtal-2011-Mercury-3D-sf.png | width2 = | alt2 = | caption = <!-- Clinical data --> | pronounce = {{IPAc-en|ˌ|n|aɪ|ə|ˈ|s|ɪ|n|ə|m|aɪ|d}}, {{IPAc-en|ˌ|n|ɪ|k|ə|ˈ|t|ɪ|n|ə|m|aɪ|d}} | tradename...")
- 11:08, 3 April 2024 Fire talk contribs created page Translations:Sulbutiamine/17/ja (Created page with "Category:Aromatic amines Category:Formamides Category:Isobutyrate esters Category:Nootropics Category:Organic disulfides Category:Pyrimidines Category:Thiamine")
- 11:08, 3 April 2024 Fire talk contribs created page Translations:Sulbutiamine/16/ja (Created page with "{{Vitamins/ja}}")
- 11:08, 3 April 2024 Fire talk contribs created page Translations:Sulbutiamine/15/ja (Created page with "== こちらも参照 == * ビタミンB<sub>1</sub>類似体 * ピリチノール")
- 11:07, 3 April 2024 Fire talk contribs created page Translations:Sulbutiamine/14/ja (Created page with "非対照臨床試験において、スルブチアミンが多発性硬化症患者の疲労軽減に有効であることが報告された。")
- 11:07, 3 April 2024 Fire talk contribs created page Translations:Sulbutiamine/13/ja (Created page with "スルブチアミンの薬理学は様々なマウスやラットで研究されており、2014年時点では、スルブチアミンがベンフォチアミンやフルスルチアミンよりも脳内のチアミンリン酸濃度を上げる効果があるように思われたが、これは完全には検証されていない。オックスフォード大学の研究では、網膜神経節細胞において、栄養因子の...")
- 11:06, 3 April 2024 Fire talk contribs created page Translations:Sulbutiamine/12/ja (Created page with "スルブチアミンは慢性疲労症候群の潜在的治療薬として臨床試験で検討されている。また 加齢に伴う概日系の変化を逆転させることへの影響も評価されている。")
- 11:06, 3 April 2024 Fire talk contribs created page Translations:Sulbutiamine/11/ja (Created page with "==研究== {{Anchor|Research}} チアミン欠乏症は、記憶やその他の認知機能に問題を引き起こすため、チアミンやスルブチアミンのような類似物質は、1980年代と1990年代に、加齢に伴う認知機能低下に対する臨床試験で研究されてきた。")
