...ulator/ja|モジュレーター]]が含まれる。 酵素標的機構には、[[enzyme activator/ja|活性化剤]]または[[enzyme inhibitor/ja|阻害剤]]が含まれる。イオンチャネル調節薬には、[[channel opener/ja|開口薬]]または[[channel blocker/ja
* [[5-alpha-reductase inhibitor/ja|5-α-還元酵素阻害薬]]
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9 KB (422 words) - 17:29, 25 March 2024
...et mechanisms include [[enzyme activator|activator]] or [[enzyme inhibitor|inhibitor]]. Ion channel modulators include [[channel opener|opener]] or [[channel bl
* [[5-alpha-reductase inhibitor|5-Alpha-reductase inhibitor]]
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7 KB (941 words) - 10:47, 25 March 2024
...et mechanisms include [[enzyme activator|activator]] or [[enzyme inhibitor|inhibitor]]. Ion channel modulators include [[channel opener|opener]] or [[channel bl
* [[5-alpha-reductase inhibitor|5-Alpha-reductase inhibitor]]
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7 KB (907 words) - 10:49, 25 March 2024
...され、最近まで[[dihydrofolate reductase/ja|ジヒドロ葉酸還元酵素]]を[[Dihydrofolate reductase inhibitor/ja|阻害]]することで作用すると考えられていた。その例には以下が含まれる：
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8 KB (367 words) - 19:05, 23 April 2024
* [[Statin]]s (HMG-CoA reductase inhibitors) are particularly well suited for lowering LDL, the cholesterol
* [[Ezetimibe]] is a selective inhibitor of dietary cholesterol absorption.
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6 KB (794 words) - 10:24, 16 April 2024
...tetrahydrofolate/ja|5,10-メチレンテトラヒドロ葉酸]]（MTHF）から[[methylenetetrahydrofolate reductase/ja|メチレンテトラヒドロ葉酸還元酵素]]（MTHFR）によって生成され、[[methionine synthase/ja|メチオニン合成酵素]]（M
...erotonin reuptake inhibitor/ja|SSRI]] や[[Serotonin–norepinephrine reuptake inhibitor/ja|SNRI]]による治療効果が一部に限られる場合の一部の患者に対して、[[First line agent/ja|第一選択]]の[[antidep
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10 KB (665 words) - 19:37, 5 April 2024
...ic form of folate, and must undergo enzymatic reduction by [[dihydrofolate reductase]] (DHFR) to become biologically active.
Levomefolic acid is generated by [[methylenetetrahydrofolate reductase]] (MTHFR) from [[5,10-methylenetetrahydrofolate]] (MTHF) and used to recycl
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8 KB (1,024 words) - 19:18, 5 April 2024
* [[Statin]]s (HMG-CoA reductase inhibitors) are particularly well suited for lowering LDL, the cholesterol
* [[Ezetimibe]] is a selective inhibitor of dietary cholesterol absorption.
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6 KB (772 words) - 10:25, 16 April 2024
...ic form of folate, and must undergo enzymatic reduction by [[dihydrofolate reductase]] (DHFR) to become biologically active.
Levomefolic acid is generated by [[methylenetetrahydrofolate reductase]] (MTHFR) from [[5,10-methylenetetrahydrofolate]] (MTHF) and used to recycl
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8 KB (1,066 words) - 19:16, 5 April 2024
...o work by [[Dihydrofolate reductase inhibitor|inhibiting]] [[dihydrofolate reductase]]. Examples include:
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7 KB (877 words) - 19:03, 23 April 2024
...o work by [[Dihydrofolate reductase inhibitor|inhibiting]] [[dihydrofolate reductase]]. Examples include:
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6 KB (835 words) - 19:05, 23 April 2024
細胞が（現在の内部[[HMG-CoA reductase/ja|HMGCoA]]産生経路を超えて）さらなるコレステロールを必要とする場合、細胞は必要な[[LDL receptor/ja|LDL受容体]]を合成
...経路]]はコレステロールを含む多くの分子の生合成の基礎となる。酵素3-ヒドロキシ-3-メチルグルタリルコエンザイムAレダクターゼ（[[HMG CoA reductase/ja|HMG CoAレダクターゼ]]）は必須成分であり、コレステロール生成経路の37段階のうち最初のステップを実行し、すべての動物細胞に存在する。
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31 KB (829 words) - 20:09, 8 March 2024
...olled trials/ja|ランダム化比較試験]]から得られた限られたエビデンスは、[[selective serotonin reuptake inhibitor/ja|選択的セロトニン再取り込み阻害薬]]（SSRI）に加えて葉酸を使用することが有益である可能性を示した。
...葉酸の生物学的活性は、葉酸を[[tetrahydrofolate/ja|テトラヒドロ葉酸]]（THF）に変換する肝臓の[[dihydrofolate reductase/ja|ジヒドロ葉酸還元酵素]]の作用に依存する。この作用はヒトでは律速的であるため、サプリメントや強化食品からの摂取量が米国の[[Dietary Re
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53 KB (1,932 words) - 15:27, 5 April 2024
=== HMG-CoA reductase inhibitors ([[statin]]s) ===
Statins competitively inhibit hydroxymethylglutaryl (HMG) CoA reductase which is used in the biosynthesis of cholesterol and they include atorvasta
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16 KB (2,114 words) - 17:52, 13 April 2024
=== HMG-CoA reductase inhibitors ([[statin]]s) ===
Statins competitively inhibit hydroxymethylglutaryl (HMG) CoA reductase which is used in the biosynthesis of cholesterol and they include atorvasta
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15 KB (2,054 words) - 17:52, 13 April 2024
...剤]], [[antiflatulent|鼓腸薬]], [[dopamine antagonist|坑ドーパミン薬]], [[proton pump inhibitor|プロトンポンプ阻害剤]] (PPIs), [[H2 receptor antagonist|H<sub>2</sub>-受容体拮抗薬]], [[Cyt
* [[blood pressure|血圧]] に影響する／[[antihypertensive drug|降圧薬]]: [[ACE inhibitor/ja|ACE阻害薬]]、[[Angiotensin II receptor antagonist/ja|アンジオテンシン受容体拮抗薬]]、[[beta
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58 KB (1,845 words) - 17:09, 5 November 2023
| -parib || [[PARP inhibitor]] || [[olaparib]], [[veliparib]]
| -rafenib || [[BRAF inhibitor]]s<ref name=<ref8>{{cite web |title=Rafenib |url=https://druginfo.nlm.nih.g
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25 KB (3,297 words) - 17:05, 3 January 2023
...after being reduced by [[cytochrome b5 reductase|cytochrome b<sub>5</sub> reductase]] (CYB<sub>5</sub>R).
;Mitochondrial P450 systems: which employ [[adrenodoxin reductase]] and [[adrenodoxin]] to transfer electrons from NADPH to P450.
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38 KB (5,401 words) - 20:37, 15 March 2024
...after being reduced by [[cytochrome b5 reductase|cytochrome b<sub>5</sub> reductase]] (CYB<sub>5</sub>R).
;Mitochondrial P450 systems: which employ [[adrenodoxin reductase]] and [[adrenodoxin]] to transfer electrons from NADPH to P450.
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39 KB (5,513 words) - 20:35, 15 March 2024
...ancer, 2-hydroxyglutarate serves as a [[Competitive inhibition|competitive inhibitor]] for a number of enzymes that facilitate reactions via alpha-ketoglutarate
...to the oxidation of succinate to fumarate. Following, [[Trans-2-enoyl-CoA reductase (NADPH)|trans-Enoyl-CoA]] is hydrated across the double bond to beta-hydrox
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38 KB (5,368 words) - 11:38, 31 March 2024