Low-density lipoprotein/ja: Difference between revisions

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===構造===

===~~Structure~~===

それぞれのネイティブLDL粒子は乳化を可能にし、すなわち運ばれる脂肪酸を取り囲み、これらの脂肪が細胞外の水中で体内を移動することを可能にする。各粒子には1個の[[apolipoprotein/ja|アポリポ蛋白質]]が含まれている。B-100分子（[[Apolipoprotein B/ja|Apo B-100]]、4536個の[[amino acid/ja|アミノ酸]]残基と514[[:en:Atomic mass unit|kDa]]の質量を持つ蛋白質）と80から100個の補助蛋白質が含まれている。各LDLは、[[Linoleic acid/ja|リノレイン酸]]として知られる[[Polyunsaturated fat/ja|多価不飽和脂肪酸]]と、数百から数千（平均値として一般的に引用される約1500）の[[ester/ja|エステル]]化および非エステル化コレステロール分子から成る高度に疎水性のコアを持つ。

Each native LDL particle enables emulsification, i.e. surrounding the fatty acids being carried, enabling these fats to move around the body within the water outside cells. Each particle contains a single [[apolipoprotein]] B-~~100 molecule (~~[[Apolipoprotein B|Apo B-100]]~~, a protein that has 4536~~ [[amino acid]] ~~residues and a mass of 514~~ [[Atomic mass unit|kDa]]~~), along with 80 to 100 additional ancillary proteins. Each LDL has a highly hydrophobic core consisting of~~ [[~~Polyunsaturated fat~~|~~polyunsaturated fatty acid~~]] ~~known as~~ [[~~Linoleic acid~~|~~linoleate~~]] ~~and hundreds to thousands (about 1500 commonly cited as an average) of~~ [[ester]]ified and unesterified cholesterol molecules. This core also carries varying numbers of triglycerides and other fats and is surrounded by a shell of phospholipids and unesterified cholesterol, as well as the single copy of Apo B-100. LDL particles are approximately 22 nm (0.00000087 in.) to 27.5 nm in diameter and have a mass of about 3 million daltons. Since LDL particles contain a variable and changing number of fatty acid molecules, there is a distribution of LDL particle mass and size. Determining the structure of LDL has been a tough task because of its heterogeneous structure. However, the structure of LDL at human body temperature in native condition, with a resolution of about 16 [[Angstroms]] using [[cryogenic electron microscopy]], has been described in 2011.

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+===構造===
-===Structure===
+それぞれのネイティブLDL粒子は乳化を可能にし、すなわち運ばれる脂肪酸を取り囲み、これらの脂肪が細胞外の水中で体内を移動することを可能にする。各粒子には1個の[[apolipoprotein/ja|アポリポ蛋白質]]が含まれている。B-100分子（[[Apolipoprotein B/ja|Apo B-100]]、4536個の[[amino acid/ja|アミノ酸]]残基と514[[:en:Atomic mass unit|kDa]]の質量を持つ蛋白質）と80から100個の補助蛋白質が含まれている。各LDLは、[[Linoleic acid/ja|リノレイン酸]]として知られる[[Polyunsaturated fat/ja|多価不飽和脂肪酸]]と、数百から数千（平均値として一般的に引用される約1500）の[[ester/ja|エステル]]化および非エステル化コレステロール分子から成る高度に疎水性のコアを持つ。
-Each native LDL particle enables emulsification, i.e. surrounding the fatty acids being carried, enabling these fats to move around the body within the water outside cells. Each particle contains a single [[apolipoprotein]] B-100 molecule ([[Apolipoprotein B|Apo B-100]], a protein that has 4536 [[amino acid]] residues and a mass of 514 [[Atomic mass unit|kDa]]), along with 80 to 100 additional ancillary proteins. Each LDL has a highly hydrophobic core consisting of [[Polyunsaturated fat|polyunsaturated fatty acid]] known as [[Linoleic acid|linoleate]] and hundreds to thousands (about 1500 commonly cited as an average) of [[ester]]ified and unesterified cholesterol molecules. This core also carries varying numbers of triglycerides and other fats and is surrounded by a shell of phospholipids and unesterified cholesterol, as well as the single copy of Apo B-100. LDL particles are approximately 22&nbsp;nm (0.00000087&nbsp;in.) to 27.5&nbsp;nm in diameter and have a mass of about 3 million daltons. Since LDL particles contain a variable and changing number of fatty acid molecules, there is a distribution of LDL particle mass and size. Determining the structure of LDL has been a tough task because of its heterogeneous structure. However, the structure of LDL at human body temperature in native condition, with a resolution of about 16 [[Angstroms]] using [[cryogenic electron microscopy]], has been described in 2011.
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