Collagen/ja: Difference between revisions

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[[Knobloch syndrome/ja|ノブロッホ症候群]] - コラーゲンXVIIIの産生をコードする[[COL18A1/ja|COL18A1]]遺伝子の変異によって引き起こされる。脳組織の突出と網膜の変性がみられる。家族にこの疾患の患者がいる場合、遺伝的な関連性があるため、自分自身が発症するリスクが高くなる。

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==特徴{{Anchor|Characteristics}}==

==Characteristics==

~~Collagen is one of the long,~~ [[fibrous protein|~~fibrous structural proteins~~]] ~~whose functions are quite different from those of~~ [[~~globular protein~~]]~~s, such as~~ [[~~enzyme~~]]~~s. Tough bundles of collagen called~~ ''~~collagen fibers~~'' ~~are a major component of the~~ [[extracellular matrix]] ~~that supports most tissues and gives cells structure from the outside, but collagen is also found inside certain cells. Collagen has great~~ [[tensile strength]]~~, and is the main component of~~ [[fascia]], [[cartilage]], [[ligament]]s, [[tendon]]s, [[bone]] ~~and skin. Along with~~ [[elastin]] ~~and soft~~ [[keratin]]~~, it is responsible for skin strength and elasticity, and its degradation leads to~~ [[~~wrinkle~~]]~~s that accompany~~ [[~~aging~~]]~~. It strengthens~~ [[blood vessel]]~~s and plays a role in~~ [[biological tissue|~~tissue~~]] ~~development. It is present in the~~ [[cornea]] ~~and lens of the eye in~~ [[crystal]]~~line form. It may be one of the most abundant proteins in the fossil record, given that it appears to fossilize frequently, even in bones from the~~ [[Mesozoic]] ~~and~~ [[Paleozoic]].

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 [[Knobloch syndrome/ja|ノブロッホ症候群]] - コラーゲンXVIIIの産生をコードする[[COL18A1/ja|COL18A1]]遺伝子の変異によって引き起こされる。脳組織の突出と網膜の変性がみられる。家族にこの疾患の患者がいる場合、遺伝的な関連性があるため、自分自身が発症するリスクが高くなる。
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+==特徴{{Anchor|Characteristics}}==
-==Characteristics==
+コラーゲンは長い[[fibrous protein/ja|繊維構造タンパク質]]の一つであり、その機能は[[enzyme/ja|酵素]]などの[[globular protein/ja|球状タンパク質]]とは全く異なる。''コラーゲン線維''と呼ばれる丈夫なコラーゲンの束は、ほとんどの組織を支え、細胞に外側から構造を与える[[extracellular matrix/ja|細胞外マトリックス]]の主要な構成要素であるが、コラーゲンはある種の細胞内部にも存在する。コラーゲンは大きな[[tensile strength/ja|引っ張り強度]]を持ち、[[fascia/ja|筋膜]]、[[cartilage/ja|軟骨]]、[[ligament/ja|靭帯]]、[[tendon/ja|腱]]、[[bone/ja|骨]]、皮膚の主成分である。[[elastin/ja|エラスチン]]や柔らかい[[keratin/ja|ケラチン]]とともに皮膚の強度と弾力性を担っており、その劣化は[[aging/ja|老化]]に伴う[[wrinkle/ja|しわ]]の原因となる。[[blood vessel/ja|血管]]を強化し、[[biological tissue/ja|組織]]の発達に関与する。眼の[[cornea/ja|角膜]]や水晶体には[[crystal/ja|結晶]]線状で存在する。[[Mesozoic/ja|中生代]]や[[Paleozoic/ja|古生代]]の骨でも頻繁に化石化することから、化石記録では最も豊富なタンパク質の1つかもしれない。
-Collagen is one of the long, [[fibrous protein|fibrous structural proteins]] whose functions are quite different from those of [[globular protein]]s, such as [[enzyme]]s. Tough bundles of collagen called ''collagen fibers'' are a major component of the [[extracellular matrix]] that supports most tissues and gives cells structure from the outside, but collagen is also found inside certain cells. Collagen has great [[tensile strength]], and is the main component of [[fascia]], [[cartilage]], [[ligament]]s, [[tendon]]s, [[bone]] and skin. Along with [[elastin]] and soft [[keratin]], it is responsible for skin strength and elasticity, and its degradation leads to [[wrinkle]]s that accompany [[aging]]. It strengthens [[blood vessel]]s and plays a role in [[biological tissue|tissue]] development. It is present in the [[cornea]] and lens of the eye in [[crystal]]line form. It may be one of the most abundant proteins in the fossil record, given that it appears to fossilize frequently, even in bones from the [[Mesozoic]] and [[Paleozoic]].
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