Translations:Antihypertensive drug/9/ja: Difference between revisions

Latest revision as of 18:23, 2 November 2023

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Message definition (Antihypertensive drug)

==ACE inhibitors==
[[File:Captopril skeletal.svg|thumb|[[Captopril]], the prototypical ACE inhibitor]]
[[ACE inhibitor]]s inhibit the activity of [[angiotensin-converting enzyme]] (ACE), an enzyme responsible for the conversion of angiotensin I into [[angiotensin]] II, a potent [[vasoconstrictor]].
* [[captopril]]
* [[enalapril]]
* [[fosinopril]]
* [[lisinopril]]
* [[moexipril]]
* [[perindopril]]
* [[quinapril]]
* [[ramipril]]
* [[trandolapril]]
* [[benazepril]]
A systematic review of 63 trials with over 35,000 participants indicated ACE inhibitors significantly reduced doubling of serum creatinine levels compared to other drugs (ARBs, α blockers, β blockers, etc.), and the authors suggested this as a first line of defense. The AASK trial showed that ACE inhibitors are more effective at slowing down the decline of [[kidney function]] compared to [[calcium channel blockers]] and [[beta blockers]]. As such, ACE inhibitors should be the drug treatment of choice for patients with [[chronic kidney disease]] regardless of race or diabetic status.

ACE阻害薬

ACE阻害薬は、アンジオテンシンIから強力な血管収縮物質であるアンジオテンシンIIへの変換を担う酵素であるアンジオテンシン変換酵素（ACE）の活性を阻害する。

35,000人以上が参加した63の試験のシステマティックレビューでは、ACE阻害薬は他の薬物（ARB、α遮断薬、β遮断薬など）に比べて血清クレアチニン値の倍加を有意に抑制することが示され、著者らはこれを第一選択薬として推奨している。AASK試験では、ACE阻害薬はカルシウム拮抗薬やβ遮断薬に比べて腎機能の低下を遅らせる効果があることが示された。そのため、ACE阻害薬は人種や糖尿病の有無にかかわらず、慢性腎臓病患者に選択されるべき薬物治療である。

Translations:Antihypertensive drug/9/ja: Difference between revisions

Latest revision as of 18:23, 2 November 2023

ACE阻害薬

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