Translations:Vitamin D5/1/ja: Difference between revisions

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Created page with "{{DISPLAYTITLE:ビタミンD<sub>5</sub>}} {{chembox | Verifiedfields = changed | verifiedrevid = 470631138 | Name=Vitamin D<sub>5</sub> | ImageFile=Vitamin D5 structure.svg | ImageSize= | IUPACName=(1''S'',3''Z'')-3-[(2''E'')-2-[(1''R'',3a''S'',7a''R'')-1-[(1''R'',4''S'')-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1''H''-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol | OtherNames= Sitocalciferol <br> (5''Z'',7''E'')-(3''S'')-9,10-secoporiferasta..."
 
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Latest revision as of 21:39, 10 April 2024

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Message definition (Vitamin D5)
{{short description|Fat soluble vitamin}}{{DISPLAYTITLE:Vitamin D<sub>5</sub>}}
{{chembox
| Verifiedfields = changed
| verifiedrevid = 470631138
| Name=Vitamin D<sub>5</sub>
| ImageFile=Vitamin D5 structure.svg
| ImageSize=
| IUPACName=(1''S'',3''Z'')-3-[(2''E'')-2-[(1''R'',3a''S'',7a''R'')-1-[(1''R'',4''S'')-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1''H''-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol
| OtherNames= Sitocalciferol <br> (5''Z'',7''E'')-(3''S'')-9,10-secoporiferasta-5,7,10(19)-trien-3-ol
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 7826639
| ChEBI = 33279
| InChI = 1/C29H48O/c1-7-23(20(2)3)12-10-22(5)27-16-17-28-24(9-8-18-29(27,28)6)13-14-25-19-26(30)15-11-21(25)4/h13-14,20,22-23,26-28,30H,4,7-12,15-19H2,1-3,5-6H3/b24-13+,25-14-/t22-,23+,26+,27-,28+,29-/m1/s1
| InChIKey = RMDJVOZETBHEAR-GHTRHTQZBN
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C29H48O/c1-7-23(20(2)3)12-10-22(5)27-16-17-28-24(9-8-18-29(27,28)6)13-14-25-19-26(30)15-11-21(25)4/h13-14,20,22-23,26-28,30H,4,7-12,15-19H2,1-3,5-6H3/b24-13+,25-14-/t22-,23+,26+,27-,28+,29-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = RMDJVOZETBHEAR-GHTRHTQZSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo=71761-06-3
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 0W2I161LCL
| PubChem=9547700
| SMILES = O[C@@H]1CC(\C(=C)CC1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@H](CC)C(C)C)C
}}
|Section2={{Chembox Properties
| C=29 | H=48 | O=1
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
  }}
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
  }}
}}
'''Vitamin D<sub>5</sub>''' ('''sitocalciferol''') is a form of [[vitamin D]].
== Research ==
[[structural analog|Analogs]] of [[calcitriol]], a form of vitamin D<sub>3</sub>, have been proposed for use as antitumor agents. Studies on vitamin D<sub>3</sub> have shown inhibition of cell proliferation in [[prostate cancer]], but high doses of vitamin D<sub>3</sub> result in [[Hypercalcaemia|hypercalcemia]]. The effects of vitamin D<sub>5</sub> on prostate cancer have also been studied, and unlike vitamin D<sub>3</sub>, vitamin D<sub>5</sub> does not cause [[Hypercalcaemia|hypercalcemia]] while inhibiting tumor cell proliferation. The most researched analogue of vitamin D<sub>5</sub> as an antitumor agent is 1α-hydroxyvitamin D<sub>5.</sub>
Vitamin D5
Names
IUPAC name
(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol
Other names
Sitocalciferol
(5Z,7E)-(3S)-9,10-secoporiferasta-5,7,10(19)-trien-3-ol
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
UNII
Properties
C29H48O
Molar mass 412.702 g·mol−1

ビタミンD5（sitocalciferol）はビタミンDの一種である。

研究

ビタミンD3の一種であるカルシトリオールのアナログが抗腫瘍剤として使用されることが提案されている。ビタミンD3に関する研究では、前立腺がんにおける細胞増殖の阻害が示されているが、ビタミンD3の高用量投与は高カルシウム血症を引き起こす。前立腺がんに対するビタミンD5の効果も研究されており、ビタミンD3とは異なり、ビタミンD5は腫瘍細胞の増殖を阻害する一方で高カルシウム血症を引き起こさない。抗腫瘍剤として最も研究されているビタミンD5の類似体は1α-ヒドロキシビタミンD5.である。

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