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Message definition (Thiamine pyrophosphate ) Thiamine pyrophosphate is synthesized in the [[cytosol]] and is required in the cytosol for the activity of transketolase and in the mitochondria for the activity of pyruvate-, oxoglutarate- and branched chain keto acid dehydrogenases. To date, the yeast ThPP carrier (Tpc1p) the human Tpc and the ''[[Drosophila melanogaster]]'' have been identified as being responsible for the mitochondrial transport of ThPP and ThMP. It was first discovered as an [[essential nutrient]] ([[vitamin]]) in humans through its link with the [[peripheral nervous system]] [[disease]] [[beriberi]], which results from a deficiency of thiamine in the [[Diet (nutrition)|diet]].
チアミンピロリン酸は細胞質 で合成され、細胞質ではトランスケトラーゼの活性に、ミトコンドリアではピルビン酸、オキソグルタル酸、分岐鎖ケト酸デヒドロゲナーゼの活性に必要である。現在までに、ThPPとThMPのミトコンドリア輸送を担うものとして、酵母ThPPキャリアー（Tpc1p）、ヒトTpc、ショウジョウバエ 食事療法 におけるチアミンの欠乏に起因する末梢神経系 の病気 脚気 との関連性から、ヒトの必須栄養素 （ビタミン ）として初めて発見された。