Translations:Methylcobalamin/4/ja: Difference between revisions

Revision as of 14:00, 7 April 2024

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Message definition (Methylcobalamin)

| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 13422-55-4
| ATC_prefix = B03
| ATC_suffix = BA05
| PubChem = 6436232
| ChemSpiderID = 29368587
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = BR1SN1JS2W
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1697757
| StdInChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;-1;+3/p-2
| StdInChIKey = ZFLASALABLFSNM-UHFFFAOYSA-L
| SMILES = [CH3-].CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3]

| C=63 | H=91 | Co=1 | N=13 | O=14 | P=1
|drug_name=|alt=|caption=|type=|MedlinePlus=|licence_EU=|licence_US=}}
'''Methylcobalamin''' (mecobalamin, MeCbl, or MeB{{sub|12}}) is a [[cobalamin]], a form of [[vitamin B12|vitamin B{{sub|12}}]]. It differs from [[cyanocobalamin]] in that the [[cyanide|cyano group]] at the cobalt is replaced with a [[methyl group]]. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. From the perspective of [[coordination chemistry]], methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. [[Nickel]]–methyl intermediates have been proposed for the final step of [[methanogenesis]].

| CAS_number_Ref = ^Y | CAS_number = 13422-55-4 | ATC_prefix = B03 | ATC_suffix = BA05 | PubChem = 6436232 | ChemSpiderID = 29368587 | DrugBank_Ref = ^Y | DrugBank = | UNII_Ref = ^N | UNII = BR1SN1JS2W | ChEMBL_Ref = ^N | ChEMBL = 1697757 | StdInChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;-1;+3/p-2 | StdInChIKey = ZFLASALABLFSNM-UHFFFAOYSA-L | SMILES = [CH3-].CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3] | C=63 | H=91 | Co=1 | N=13 | O=14 | P=1 |drug_name=|alt=|caption=|type=|MedlinePlus=|licence_EU=|licence_US=}} メチルコバラミン（Methylcobalamin, メコバラミン、MeCbl、MeB₁₂）は、[[Vitamin B12|ビタミンB₁₂]の一種であるコバラミンである。］コバルトのシアノ基がメチル基に置換されている点でシアノコバラミンとは異なる。メチルコバラミンは八面体のコバルト(III)中心を持ち、明るい赤色の結晶として得られる。配位化学の観点からは、メチルコバラミンが金属-アルキル結合を含む化合物の珍しい例として注目される。ニッケル-メチル中間体は、メタン生成の最終段階として提案されている。

Translations:Methylcobalamin/4/ja: Difference between revisions

Revision as of 14:00, 7 April 2024

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