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Message definition (Obesity ) Health consequences fall into two broad categories: those attributable to the effects of increased fat mass (such as [[osteoarthritis]], [[obstructive sleep apnea]], social stigmatization) and those due to the increased number of [[fat cells]] ([[diabetes mellitus|diabetes]], [[cancer]], [[cardiovascular disease]], [[non-alcoholic fatty liver disease]]). Increases in body fat alter the body's response to insulin, potentially leading to [[insulin resistance]]. Increased fat also creates a [[inflammation|proinflammatory state]], and a [[thrombosis|prothrombotic]] state. {| class="wikitable" |- ! Medical field ! Condition ! Medical field ! Condition |- | width="10%" | [[Cardiology]] | * [[Coronary heart disease]]: [[angina pectoris|angina]] and [[myocardial infarction]] * [[Congestive heart failure]] * [[High blood pressure]] * [[Dyslipidemia|Abnormal cholesterol levels]] * [[Deep vein thrombosis]] and [[pulmonary embolism]] | [[Dermatology]] | * [[Acanthosis nigricans]] * [[Lymphedema]] * [[Cellulitis]] * [[Hirsutism]] * [[Intertrigo]] |- | [[Endocrinology]] and [[reproductive medicine]] | * [[Diabetes mellitus]] * [[Polycystic ovarian syndrome]] * [[menstruation|Menstrual]] disorders * [[Infertility]] * [[Maternal obesity|Complications during pregnancy]] * [[Birth defects]] * [[Stillbirth|Intrauterine fetal death]] | <!--Alphabetized-->[[Gastroenterology]] | * [[Gastroesophageal reflux disease]] * [[Non-alcoholic fatty liver disease|Fatty liver disease]] * [[Cholelithiasis]] (gallstones) |- | [[Neurology]] | style="width:40%;" | * [[Stroke]] * [[Meralgia paresthetica]] * [[Migraines]] * [[Carpal tunnel syndrome]] * [[Dementia]] * [[Idiopathic intracranial hypertension]] * [[Multiple sclerosis]] | [[Oncology]] | * [[esophageal cancer|Esophageal]] * [[colorectal cancer|Colorectal]] * [[pancreatic cancer|Pancreatic]] * [[Gallbladder cancer|Gallbladder]] * [[Endometrial cancer|Endometrial]] * [[Renal cell carcinoma|Kidney]] * [[Leukemia]] * [[Hepatocellular carcinoma]] * [[Malignant melanoma]] |- | style="width:10%;" |[[Psychiatry]] | style="width:40%;" | * [[Major depressive disorder|Depression]] in women * Social [[Social stigma|stigmatization]] | [[Respirology]] | * [[Sleep apnea|Obstructive sleep apnea]] * [[Obesity hypoventilation syndrome]] * [[Asthma]] * Increased complications during [[general anaesthesia]] * increased risk of severe COVID-19 |- | [[Rheumatology]] and [[orthopedics]] | * [[Gout]] * Poor mobility * [[Osteoarthritis]] * [[Low back pain]] | [[Urology]] and [[Nephrology]] | * [[Erectile dysfunction]] * [[Urinary incontinence]] * [[Chronic renal failure]] * [[Hypogonadism]] * [[Buried penis]] |}
健康への影響は大きく2つのカテゴリーに分類される:脂肪量の増加の影響に起因するもの(変形性関節症 、閉塞性睡眠時無呼吸症候群 、社会的汚名など)と脂肪細胞 の増加によるもの(糖尿病 、がん 、心血管系疾患 、非アルコール性脂肪肝疾患 )。体脂肪の増加はインスリンに対する身体の反応を変化させ、潜在的にインスリン抵抗性 を引き起こす。脂肪の増加はまた、炎症性状態 や血栓性状態 を引き起こす。