Pantothenic acid/en: Difference between revisions
Pantothenic acid/en
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# PPC is [[Decarboxylation|decarboxylated]] to [[4'-phosphopantetheine|4′-phosphopantetheine]] by [[phosphopantothenoylcysteine decarboxylase]] | # PPC is [[Decarboxylation|decarboxylated]] to [[4'-phosphopantetheine|4′-phosphopantetheine]] by [[phosphopantothenoylcysteine decarboxylase]] | ||
# 4′-Phosphopantetheine is adenylated (or more properly, [[Adenylation|AMPylated]]) to form dephospho-CoA by the enzyme [[Pantetheine-phosphate adenylyltransferase|phosphopantetheine adenylyl transferase]] | # 4′-Phosphopantetheine is adenylated (or more properly, [[Adenylation|AMPylated]]) to form dephospho-CoA by the enzyme [[Pantetheine-phosphate adenylyltransferase|phosphopantetheine adenylyl transferase]] | ||
# Finally, dephospho-CoA is phosphorylated to coenzyme A by the enzyme [[dephospho-CoA kinase|dephosphocoenzyme A kinase]]. This final step also requires ATP. | # Finally, dephospho-CoA is phosphorylated to coenzyme A by the enzyme [[dephospho-CoA kinase|dephosphocoenzyme A kinase]]. This final step also requires ATP. | ||
This pathway is suppressed by [[end-product inhibition]], meaning that CoA is a competitive inhibitor of pantothenate kinase, the enzyme responsible for the first step. | This pathway is suppressed by [[end-product inhibition]], meaning that CoA is a competitive inhibitor of pantothenate kinase, the enzyme responsible for the first step. | ||