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- chemical compound5 statements, 0 sitelinks - 07:59, 22 December 2023
- Catalysis of the reaction: isopenicillin N = penicillin N.6 statements, 0 sitelinks - 08:00, 22 December 2023
- Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate.11 statements, 0 sitelinks - 07:59, 22 December 2023
- The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of med4 statements, 0 sitelinks - 19:40, 21 December 2023
- The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the cult5 statements, 0 sitelinks - 07:54, 22 December 2023
- Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate.4 statements, 0 sitelinks - 08:02, 22 December 2023
- ...on, Pennsylvania|ペンシルバニア州エクストン]]に本社を置いている。Westは開発初期に、注射剤の包装用ゴム部品を製造し、[[:en:penicillin|ぺニシリン]]や[[:en:insulin|インスリン]]の生産者に無菌環境を提供していた。 ...6 KB (590 words) - 08:58, 19 January 2024
- ...r = [[Drugs.com]] | access-date = 2013-01-01 | date = 2010-12-15 | title = Penicillin }}</ref> ...25 KB (3,297 words) - 17:05, 3 January 2023
- 戦間期には、[[sulpha/ja|スルファ]]抗生物質などの最初の抗菌剤が開発された。第二次世界大戦では、[[penicillin/ja|ペニシリン]]系抗生物質の開発と大量生産により、広範囲で効果的な抗菌療法が導入された。戦争の圧力と、イギリスの科学者とアメリカの[[pharma ...xin/ja|抗毒素]]、少数の生物学的ワクチン、少数の合成薬があった。1930年代には、まず[[sulfa drug/ja|サルファ剤]]、次に[[penicillin/ja|ペニシリン]]などの抗生物質が登場した。医薬品は次第に「医療行為の中心」となっていった。1950年代には、[[inflammation/ja|炎 ...58 KB (1,845 words) - 17:09, 5 November 2023
- ...ja|不可逆的阻害剤]]は、通常タンパク質に[[covalent bond/ja|共有結合]]を形成することによって、酵素を永久的に不活性化する。[[penicillin/ja|ペニシリン]]や[[aspirin/ja|アスピリン]]はこの方法で作用する一般的な薬物である。 ...of gene expression/ja|遺伝子調節]]の形態を[[enzyme induction/ja|酵素誘導]]と呼ぶ。例えば、細菌が[[penicillin/ja|ペニシリン]]などの[[antibiotic resistance/ja|抗生物質耐性]]になるのは、ペニシリン分子内の重要な[[Beta-la ...64 KB (2,204 words) - 15:33, 22 February 2024
- ...eria and other microorganisms by a chemical substance of microbial origin. Penicillin, introduced a few years later, provided a broader spectrum of activity comp ...microbial therapy with the development and mass production of [[penicillin|penicillin]] antibiotics, made possible by the pressures of the war and the collaborat ...52 KB (6,923 words) - 17:09, 5 November 2023
- ...eria and other microorganisms by a chemical substance of microbial origin. Penicillin, introduced a few years later, provided a broader spectrum of activity comp ...microbial therapy with the development and mass production of [[penicillin|penicillin]] antibiotics, made possible by the pressures of the war and the collaborat ...54 KB (7,245 words) - 17:08, 5 November 2023
- ...ogical Laboratoriesを買収し、[[:en:Allies of World War II|第二次世界大戦の連合軍]]向けに[[:en:penicillin|ペニシリン]]を生産するために工場を改造した。 戦後、同社は1945年に工場を[[Wikipedia:Bristol Laboratories|Bri ...31 KB (1,756 words) - 14:11, 5 October 2023
- ...vates the enzyme, usually by forming a [[covalent bond]] to the protein. [[Penicillin]] and [[aspirin]] are common drugs that act in this manner. ...ced that hydrolyse the crucial [[Beta-lactam|beta-lactam ring]] within the penicillin molecule. Another example comes from enzymes in the [[liver]] called [[cyto ...52 KB (7,533 words) - 19:19, 21 February 2024
- ...vates the enzyme, usually by forming a [[covalent bond]] to the protein. [[Penicillin]] and [[aspirin]] are common drugs that act in this manner. ...ced that hydrolyse the crucial [[Beta-lactam|beta-lactam ring]] within the penicillin molecule. Another example comes from enzymes in the [[liver]] called [[cyto ...54 KB (7,773 words) - 19:18, 21 February 2024
- ...y [[serendipity|serendipitous]] discovery, [[History of penicillin|as with penicillin]]. More recently, [[chemical library|chemical libraries]] of synthetic [[sm ...antibiotic discovered as a defense mechanism against another microbe is [[penicillin]] in bacterial cultures contaminated by ''[[Penicillium]]'' fungi in 1928.{ ...55 KB (7,244 words) - 08:05, 4 January 2023
- ====Early anti-infective research: Salvarsan, Prontosil, Penicillin and vaccines==== In 1928, [[Alexander Fleming]] discovered the antibacterial effects of [[penicillin]], but its exploitation for the treatment of human disease awaited the deve ...60 KB (8,551 words) - 22:13, 8 January 2023
- ...ウハウを身につけていった。この技術は、[[:en:World War II|第二次世界大戦]]中、負傷した連合軍兵士の治療に必要な抗生物質[[:en:penicillin|ペニシリン]]の大量生産にも応用された。Pfizerは、深層タンク発酵によるペニシリンの大量生産に成功したのである。その成功により、終戦までに連合軍の ...63 KB (2,369 words) - 10:05, 3 January 2024
- ...ne programs have greatly reduced the prevalence of infections resistant to penicillin or other first-line antibiotics.<ref>{{cite web|url=https://www.nature.com/ ...128 KB (17,153 words) - 16:41, 3 January 2023