...いが、[[virtual screening/ja|バーチャルスクリーニング]]（VS）では高いヒット率を得ることができる。例えば[[virtual screening/ja|VS]]は、[[dipeptidyl peptidase-4/ja|DPP-4]]のS1およびS2部位に配置できる[[wikt:part|フラグ
[[pyrrolidine/ja|ピロリジン]]型の[[DPP-4 inhibitor/ja|DPP-4阻害剤]]は、[[High throughput screening/ja|HTS]]の後に初めて発見された。研究により、[[pyrrolidine/ja|ピロリジン]]環が化合物の[[binding site/ja|結
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41 KB (1,558 words) - 17:16, 12 March 2024
...espond to more than 5,000 genes). It also contains RNA interference (RNAi) screening assays that target over 15,000 genes.<ref>{{Cite journal |last1=Kim |first1
...nology Information|access-date = 7 January 2011}}</ref>) [[high-throughput screening]] programs with several million values.
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11 KB (1,477 words) - 15:23, 14 November 2023
...t combined with several exposed [[aromatic]] [[side chain]]s for achieving high affinity small molecule binding.
...ence in size and shape of the pocket that indicates that the S1-pocket has high specificity for [[proline]] residues
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32 KB (4,417 words) - 10:31, 12 March 2024
...t combined with several exposed [[aromatic]] [[side chain]]s for achieving high affinity small molecule binding.
...ence in size and shape of the pocket that indicates that the S1-pocket has high specificity for [[proline]] residues
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33 KB (4,561 words) - 10:30, 12 March 2024
...purified proteins, it has become common practice to use [[high throughput screening]] of large compounds libraries against isolated [[biological target]]s whic
...nity Agonist of the Nuclear Receptor RORα (NR1F1). Journal of Biomolecular Screening. 2014;19(3):399–406. https://doi.org/10.1177/1087057113497095.</ref> [[medi
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55 KB (7,244 words) - 08:05, 4 January 2023
...become common practice to use [[high throughput screening|high throughput screening]] of large compounds libraries against isolated [[biological target|biologi
Modern drug discovery involves the identification of screening hits, [[medicinal chemistry|medicinal chemistry]] and optimization of those
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52 KB (6,923 words) - 17:09, 5 November 2023
...become common practice to use [[high throughput screening|high throughput screening]] of large compounds libraries against isolated [[biological target|biologi
Modern drug discovery involves the identification of screening hits, [[medicinal chemistry|medicinal chemistry]] and optimization of those
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54 KB (7,245 words) - 17:08, 5 November 2023
...される単離された[[biological target/ja|生物学的標的]]に対して、大量の化合物ライブラリーを[[high throughput screening/ja|ハイスループットスクリーニング]]することが一般的になった。このようなスクリーニングで得られたヒット化合物は、細胞で、そして動物で[[effic
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58 KB (1,845 words) - 17:09, 5 November 2023
* A drug's characteristics make a clear distinction between tissues with high and low blood flow.
...herefore necessary to adjust the dose or other treatment parameters when a high dosage is required.
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44 KB (6,066 words) - 12:21, 15 November 2023
...ットとしてアミノ酸の芳香族オキシム誘導体を使用し、成長するペプチド鎖に順番に付加していく。ペプチドのライブラリーは[[high-throughput screening/ja|ハイスループットスクリーニング]]を通じて薬物発見に使われる。
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59 KB (2,228 words) - 10:59, 31 March 2024
...ded in sequencing the highly complex structure of [[RNA polymerase]] using high intensity X-rays from [[synchrotrons]].
...ynthesis]] techniques such as [[chemical ligation]] to produce peptides in high yield. Chemical synthesis allows for the introduction of non-natural amino
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55 KB (7,841 words) - 18:41, 23 April 2024
...ded in sequencing the highly complex structure of [[RNA polymerase]] using high intensity X-rays from [[synchrotrons]].
...ynthesis]] techniques such as [[chemical ligation]] to produce peptides in high yield. Chemical synthesis allows for the introduction of non-natural amino
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56 KB (8,015 words) - 18:40, 23 April 2024
...tion of [[tyrosine]] (Tyr, Y). The hydroxyl of tyrosine can deprotonate at high pH forming the negatively charged phenolate. Because of this one could plac
...Libraries of peptides are used in drug discovery through [[high-throughput screening]].
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47 KB (6,761 words) - 10:25, 29 March 2024
...tion of [[tyrosine]] (Tyr, Y). The hydroxyl of tyrosine can deprotonate at high pH forming the negatively charged phenolate. Because of this one could plac
...Libraries of peptides are used in drug discovery through [[high-throughput screening]].
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49 KB (6,979 words) - 10:25, 29 March 2024
...|last1 =Da Silva|display-authors=etal|first1=Cecilia |year=2013|title =The High Polyphenol Content of Grapevine Cultivar Tannat Berries Is Conferred Primar
...thumb|upright|The anticancer drug [[Paclitaxel|taxol]] was developed after screening of the Pacific yew, ''[[Taxus brevifolia]]'' (foliage and fruit shown) in 1
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72 KB (9,763 words) - 10:14, 3 January 2023