アデノシルコバラミン
Adenosylcobalamin/ja
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| Routes of administration | Oral |
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| Formula | C72H100CoN18O17P |
| Molar mass | 1579.608 g·mol−1 |
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Adenosylcobalamin (AdoCbl), also known as coenzyme B12, cobamamide, and dibencozide, is, along with methylcobalamin (MeCbl), one of the biologically active forms of vitamin B12.
アデノシルコバラミンは、ラジカルを介した1,2-炭素骨格の転位において補因子として関与する。これらのプロセスには、炭素-コバルト結合のホモ分解によるデオキシアデノシルラジカルの形成が必要である。この結合は非常に弱く、結合解離エネルギーは31kcal/molであり、酵素活性部位の化学環境ではさらに低下する。アデノシルコバラミンを補因子として用いる酵素にメチルマロニル-CoAミューターゼ（MCM）がある。
Further experimentation has also determined adenosylcobalamin's role in regulating expression of some bacterial genes. By binding to CarH, AdoCbl can modulate carotenoid genes, which confer warm colors onto various plants. Carotenoid transcription is activated by sunlight, due to the response from AdoCbl. There are other photoreceptors across different bacterial communities, aside from CarH, that also have reactive capability when bound to AdoCbl. For instance, AerR is another factor that uses AdoCbl to give off purple pigmentation. Additional examination of adenosylcobalamin-bound enzymes and the development of this cofactor over time may prove to hold regulatory function of DNA and RNA.
See also
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