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Catecholamine and trace amine biosynthesis
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Biosynthetic pathways for
catecholamines
and
trace amines
in the
human brain
L
-Phenylalanine
L
-Tyrosine
L
-DOPA
Epinephrine
Phenethylamine
p
-Tyramine
Dopamine
Norepinephrine
N
-Methylphenethylamine
N
-Methyltyramine
p
-Octopamine
Synephrine
3-Methoxytyramine
AADC
AADC
AADC
primary
pathway
PNMT
PNMT
PNMT
PNMT
AAAH
AAAH
brain
CYP2D6
minor
pathway
COMT
DBH
DBH
In humans,
catecholamines
and phenethylaminergic
trace amines
are derived from the
amino acid
L-phenylalanine
.
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