Dietary fiber: Difference between revisions
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{{short description|Portion of plant-derived food that cannot be completely digested}} | {{short description|Portion of plant-derived food that cannot be completely digested}} | ||
[[File:Fruit, Vegetables and Grain NCI Visuals Online.jpg|thumb|Foods rich in fibers: fruits, vegetables and grains]] | [[File:Fruit, Vegetables and Grain NCI Visuals Online.jpg|thumb|Foods rich in fibers: fruits, vegetables and grains]] | ||
[[File:WheatBran.jpg|thumb|[[Wheat]] [[bran]] has a high content of dietary fiber.]] | [[File:WheatBran.jpg|thumb|[[Wheat]] [[bran]] has a high content of dietary fiber.]] | ||
'''Dietary fiber''' (in [[English in the Commonwealth of Nations|Commonwealth English]] '''fibre''') or '''roughage''' is the portion of plant-derived [[food]] that cannot be completely broken down by human [[digestive enzyme]]s. | '''Dietary fiber''' (in [[English in the Commonwealth of Nations|Commonwealth English]] '''fibre''') or '''roughage''' is the portion of plant-derived [[food]] that cannot be completely broken down by human [[digestive enzyme]]s. Dietary fibers are diverse in chemical composition, and can be grouped generally by their [[solubility]], [[viscosity]], and [[Fermentation#Biological role|fermentability]], which affect how fibers are processed in the body. Dietary fiber has two main components: soluble fiber and insoluble fiber, which are components of plant-based foods, such as [[legume]]s, [[whole grain]]s and [[cereal]]s, [[vegetable]]s, [[fruit]]s, and [[nut (fruit)|nuts]] or [[seed]]s. A diet high in regular fiber consumption is generally associated with supporting health and lowering the risk of several diseases. Dietary fiber consists of non-[[starch]] [[polysaccharide]]s and other plant components such as [[cellulose]], [[resistant starch]], resistant [[dextrin]]s, [[inulin]], [[lignin]]s, [[chitin]]s (in [[fungi]]), [[pectin]]s, [[beta-glucan]]s, and [[oligosaccharide]]s. | ||
Food sources of dietary fiber have traditionally been divided according to whether they provide soluble or insoluble fiber. Plant foods contain both types of fiber in varying amounts, according to the fiber characteristics of viscosity and fermentability. | Food sources of dietary fiber have traditionally been divided according to whether they provide soluble or insoluble fiber. Plant foods contain both types of fiber in varying amounts, according to the fiber characteristics of viscosity and fermentability. Advantages of consuming fiber depend upon which type of fiber is consumed and which benefits may result in the gastrointestinal system. Bulking fibers – such as [[cellulose]] and [[hemicellulose]] (including [[psyllium]]) – absorb and hold water, promoting bowel movement regularity. Viscous fibers – such as beta-glucan and psyllium – thicken the fecal mass. Fermentable fibers – such as [[resistant starch]], [[xanthan gum]], and [[inulin]] – feed the bacteria and [[microbiota]] of the [[large intestine]], and are [[metabolism|metabolized]] to yield short-chain fatty acids, which have diverse roles in gastrointestinal health. | ||
Soluble fiber (''fermentable fiber'' or ''prebiotic fiber'') – which dissolves in water – is generally fermented in the [[colon (anatomy)|colon]] into gases and physiologically active [[by-product]]s, such as [[short-chain fatty acid]]s produced in the colon by [[Gut flora|gut bacteria]]. Examples are [[beta-glucan]]s (in oats, barley, and mushrooms) and raw [[guar gum]]. [[Psyllium]] {{ndash}} a soluble, viscous, nonfermented fiber {{ndash}} is a bulking fiber that retains water as it moves through the [[digestive system]], easing [[defecation]]. Soluble fiber is generally [[viscous]] and delays [[Stomach#Function|gastric emptying]] which, in humans, can result in an extended feeling of fullness. | Soluble fiber (''fermentable fiber'' or ''prebiotic fiber'') – which dissolves in water – is generally fermented in the [[colon (anatomy)|colon]] into gases and physiologically active [[by-product]]s, such as [[short-chain fatty acid]]s produced in the colon by [[Gut flora|gut bacteria]]. Examples are [[beta-glucan]]s (in oats, barley, and mushrooms) and raw [[guar gum]]. [[Psyllium]] {{ndash}} a soluble, viscous, nonfermented fiber {{ndash}} is a bulking fiber that retains water as it moves through the [[digestive system]], easing [[defecation]]. Soluble fiber is generally [[viscous]] and delays [[Stomach#Function|gastric emptying]] which, in humans, can result in an extended feeling of fullness. [[Inulin]] (in [[chicory]] root), [[wheat dextrin]], [[oligosaccharide]]s, and [[resistant starch]]es (in legumes and bananas), are soluble non-viscous fibers. Regular intake of soluble fibers, such as [[beta-glucan]]s from oats or [[barley]], has been established to lower blood levels of [[low-density lipoprotein|LDL]] [[cholesterol]], a risk factor for [[cardiovascular disease]]s. Soluble fiber supplements also significantly lower LDL cholesterol. | ||
Insoluble fiber – which does not dissolve in water – is inert to digestive enzymes in the upper [[gastrointestinal tract]]. Examples are wheat bran, [[cellulose]], and [[lignin]]. Coarsely ground insoluble fiber triggers the secretion of mucus in the large intestine, providing bulking. Finely ground insoluble fiber does not have this effect and can actually have a constipating effect. | Insoluble fiber – which does not dissolve in water – is inert to digestive enzymes in the upper [[gastrointestinal tract]]. Examples are wheat bran, [[cellulose]], and [[lignin]]. Coarsely ground insoluble fiber triggers the secretion of mucus in the large intestine, providing bulking. Finely ground insoluble fiber does not have this effect and can actually have a constipating effect. Some forms of insoluble fiber, such as resistant starches, can be fermented in the colon. | ||
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==Definition== | ==Definition== | ||
Dietary fiber is defined to be plant components that are not broken down by human digestive enzymes. | Dietary fiber is defined to be plant components that are not broken down by human digestive enzymes. In the late 20th century, only [[lignin]] and some [[polysaccharide]]s were known to satisfy this definition, but in the early 21st century, [[resistant starch]] and [[oligosaccharide]]s were included as dietary fiber components. The most accepted definition of dietary fiber is "all polysaccharides and lignin, which are not digested by the endogenous secretion of the human digestive tract". Currently, most animal nutritionists are using either a physiological definition, "the dietary components resistant to degradation by mammalian enzymes", or a chemical definition, "the sum of non-starch polysaccharides (NSP) and lignin". | ||
==Types and sources== | ==Types and sources== | ||
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|- | |- | ||
|- style="background:#E0E0E0;" | |- style="background:#E0E0E0;" | ||
|align="left" |[[Resistant starch]] || || align="left" | Can be starch protected by seed or shell (type RS1), granular starch (type RS2) or retrograded starch (type RS3) | |align="left" |[[Resistant starch]] || || align="left" | Can be starch protected by seed or shell (type RS1), granular starch (type RS2) or retrograded starch (type RS3) | ||
|- | |- | ||
|align="left" | [[Resistant starch]] || — || align="left" | high amylose corn, [[barley]], high amylose wheat, legumes, raw bananas, cooked and cooled pasta and potatoes | |align="left" | [[Resistant starch]] || — || align="left" | high amylose corn, [[barley]], high amylose wheat, legumes, raw bananas, cooked and cooled pasta and potatoes | ||
|- | |- | ||
|- style="background:#B9FFC5;" | |- style="background:#B9FFC5;" | ||
|align="center" colspan=3 | '''water-soluble dietary fibers''' | |align="center" colspan=3 | '''water-soluble dietary fibers''' | ||
|- style="background:#E0E0E0;" | |- style="background:#E0E0E0;" | ||
|align="left" |[[Arabinoxylan]] (a [[hemicellulose]])|| — || align="left" | [[psyllium]] | |align="left" |[[Arabinoxylan]] (a [[hemicellulose]])|| — || align="left" | [[psyllium]] | ||
|- style="background:#E0E0E0;" | |- style="background:#E0E0E0;" | ||
|align="left" |[[Fructan]]s || || align="left" | replace or complement in some [[plant]] taxa the [[starch]] as storage carbohydrate | |align="left" |[[Fructan]]s || || align="left" | replace or complement in some [[plant]] taxa the [[starch]] as storage carbohydrate | ||
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[[File:Kids ‘n Fiber (6121371164).jpg|thumb|Children eating fiber-rich food]] | [[File:Kids ‘n Fiber (6121371164).jpg|thumb|Children eating fiber-rich food]] | ||
Dietary fiber is found in fruits, vegetables and [[whole grains]]. The amounts of fiber contained in common foods are listed in the following table: | Dietary fiber is found in fruits, vegetables and [[whole grains]]. The amounts of fiber contained in common foods are listed in the following table: | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
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! Food group || Serving mean || Fibermass per serving | ! Food group || Serving mean || Fibermass per serving | ||
|- | |- | ||
| Fruit || 120 [[:millilitre|mL]] (0.5 cup) | | Fruit || 120 [[:millilitre|mL]] (0.5 cup) || 1.1 [[Gram|g]] | ||
|- | |- | ||
| Dark green vegetables || 120 mL (0.5 cup) || 6.4 g | | Dark green vegetables || 120 mL (0.5 cup) || 6.4 g | ||
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|} | |} | ||
Dietary fiber is found in plants, typically eaten whole, raw or cooked, although fiber can be added to make [[dietary supplement]]s and fiber-rich [[processed foods]]. Grain bran products have the highest fiber contents, such as crude corn bran (79 g per 100 g) and crude wheat bran (43 g per 100 g), which are ingredients for manufactured foods. | Dietary fiber is found in plants, typically eaten whole, raw or cooked, although fiber can be added to make [[dietary supplement]]s and fiber-rich [[processed foods]]. Grain bran products have the highest fiber contents, such as crude corn bran (79 g per 100 g) and crude wheat bran (43 g per 100 g), which are ingredients for manufactured foods. Medical authorities, such as the [[Mayo Clinic]], recommend adding fiber-rich products to the [[Standard American Diet]] (SAD) because it is rich in processed and artificially sweetened foods, with minimal intake of vegetables and legumes. | ||
===Plant sources=== | ===Plant sources=== | ||
Some plants contain significant amounts of soluble and insoluble fiber. For example, [[plum]]s and [[prune]]s have a thick skin covering a juicy pulp. The skin is a source of insoluble fiber, whereas soluble fiber is in the pulp. Grapes also contain a fair amount of fiber. | Some plants contain significant amounts of soluble and insoluble fiber. For example, [[plum]]s and [[prune]]s have a thick skin covering a juicy pulp. The skin is a source of insoluble fiber, whereas soluble fiber is in the pulp. Grapes also contain a fair amount of fiber. | ||
==== Soluble fiber ==== | ==== Soluble fiber ==== | ||
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* vegetables such as [[green bean]]s, [[cauliflower]], [[zucchini]] (courgette), [[celery]], and [[nopal]] | * vegetables such as [[green bean]]s, [[cauliflower]], [[zucchini]] (courgette), [[celery]], and [[nopal]] | ||
* some fruits including [[avocado]], and unripe [[banana]]s | * some fruits including [[avocado]], and unripe [[banana]]s | ||
* the skins of some fruits, including [[kiwifruit]], [[grape]]s and [[tomato]]es | * the skins of some fruits, including [[kiwifruit]], [[grape]]s and [[tomato]]es | ||
===Supplements=== | ===Supplements=== | ||
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==== Soluble fiber ==== | ==== Soluble fiber ==== | ||
Soluble fiber supplements may be beneficial for alleviating symptoms of [[irritable bowel syndrome]], such as [[diarrhea]] or [[constipation]] and abdominal discomfort. | Soluble fiber supplements may be beneficial for alleviating symptoms of [[irritable bowel syndrome]], such as [[diarrhea]] or [[constipation]] and abdominal discomfort. [[Prebiotic (nutrition)|Prebiotic]] soluble fiber products, like those containing [[inulin]] or [[oligosaccharide]]s, may contribute to relief from [[inflammatory bowel disease]], as in [[Crohn's disease]], [[ulcerative colitis]], and ''[[Clostridium difficile (bacteria)|Clostridium difficile]]'', due in part to the short-chain [[fatty acid]]s produced with subsequent [[anti-inflammatory]] actions upon the bowel. Fiber supplements may be effective in an overall dietary plan for managing irritable bowel syndrome by modification of food choices. | ||
==== Insoluble fiber ==== | ==== Insoluble fiber ==== | ||
One insoluble fiber, [[resistant starch]] from high-amylose corn, has been used as a supplement and may contribute to improving insulin sensitivity and glycemic management | One insoluble fiber, [[resistant starch]] from high-amylose corn, has been used as a supplement and may contribute to improving insulin sensitivity and glycemic management as well as promoting regularity and possibly relief of diarrhea. One preliminary finding indicates that resistant [[corn starch]] may reduce symptoms of ulcerative colitis. | ||
====Inulins==== | ====Inulins==== | ||
{{Main|Inulin}} | {{Main|Inulin}} | ||
Chemically defined as [[oligosaccharide]]s and occurring naturally in most plants, inulins have nutritional value as [[carbohydrates]], or more specifically as [[fructan]]s, a [[polymer]] of the natural plant sugar, [[fructose]]. Inulin is typically extracted by manufacturers from enriched plant sources such as [[chicory]] roots or [[Jerusalem artichoke]]s for use in prepared foods. | Chemically defined as [[oligosaccharide]]s and occurring naturally in most plants, inulins have nutritional value as [[carbohydrates]], or more specifically as [[fructan]]s, a [[polymer]] of the natural plant sugar, [[fructose]]. Inulin is typically extracted by manufacturers from enriched plant sources such as [[chicory]] roots or [[Jerusalem artichoke]]s for use in prepared foods. Subtly sweet, it can be used to replace sugar, fat, and flour, is often used to improve the flow and mixing qualities of powdered [[nutritional supplements]], and has potential health value as a [[prebiotic (nutrition)|prebiotic]] fermentable fiber. | ||
As a prebiotic fermentable fiber, inulin is [[metabolism|metabolized]] by [[gut flora]] to yield short-chain fatty acids ([[#Short-chain fatty acids|see below]]), which increase absorption of [[calcium]], | As a prebiotic fermentable fiber, inulin is [[metabolism|metabolized]] by [[gut flora]] to yield short-chain fatty acids ([[#Short-chain fatty acids|see below]]), which increase absorption of [[calcium]], [[magnesium]], and [[iron]]. | ||
The primary disadvantage of inulin is its fermentation within the intestinal tract, possibly causing [[flatulence]] and digestive distress at doses higher than 15 grams/day in most people. | The primary disadvantage of inulin is its fermentation within the intestinal tract, possibly causing [[flatulence]] and digestive distress at doses higher than 15 grams/day in most people. Individuals with digestive diseases have benefited from removing [[fructose]] and inulin from their diet. While clinical studies have shown changes in the [[microbiota]] at lower levels of [[inulin]] intake, higher intake amounts may be needed to achieve effects on body weight. | ||
====Vegetable gums==== | ====Vegetable gums==== | ||
[[Natural gum|Vegetable gum]] fiber supplements are relatively new to the market. Often sold as a powder, vegetable gum fibers dissolve easily with no aftertaste. In preliminary clinical trials, they have proven effective for the treatment of irritable bowel syndrome. | [[Natural gum|Vegetable gum]] fiber supplements are relatively new to the market. Often sold as a powder, vegetable gum fibers dissolve easily with no aftertaste. In preliminary clinical trials, they have proven effective for the treatment of irritable bowel syndrome. Examples of vegetable gum fibers are [[guar gum]] and [[gum arabic]]. | ||
==Activity in the gut== | ==Activity in the gut== | ||
Many molecules that are considered to be "dietary fiber" are so because humans lack the necessary enzymes to split the [[glycosidic bond]] and they reach the large intestine. Many foods contain varying types of dietary fibers, all of which contribute to health in different ways. | Many molecules that are considered to be "dietary fiber" are so because humans lack the necessary enzymes to split the [[glycosidic bond]] and they reach the large intestine. Many foods contain varying types of dietary fibers, all of which contribute to health in different ways. | ||
Dietary fibers make three primary contributions: bulking, viscosity and fermentation. | Dietary fibers make three primary contributions: bulking, viscosity and fermentation.Different fibers have different effects, suggesting that a variety of dietary fibers contribute to overall health. Some fibers contribute through one primary mechanism. For instance, cellulose and wheat bran provide excellent bulking effects, but are minimally fermented. Alternatively, many dietary fibers can contribute to health through more than one of these mechanisms. For instance, psyllium provides bulking as well as viscosity. | ||
Bulking fibers can be soluble (e.g. psyllium) or insoluble (e.g. cellulose and hemicellulose). They absorb water and can significantly increase stool weight and regularity. Most bulking fibers are not fermented or are minimally fermented throughout the intestinal tract. | Bulking fibers can be soluble (e.g. psyllium) or insoluble (e.g. cellulose and hemicellulose). They absorb water and can significantly increase stool weight and regularity. Most bulking fibers are not fermented or are minimally fermented throughout the intestinal tract. | ||
Viscous fibers thicken the contents of the intestinal tract and may attenuate the absorption of sugar, reduce sugar response after eating, and reduce lipid absorption (notably shown with cholesterol absorption). Their use in food formulations is often limited to low levels, due to their viscosity and thickening effects. Some viscous fibers may also be partially or fully fermented within the intestinal tract (guar gum, beta-glucan, glucomannan and pectins), but some viscous fibers are minimally or not fermented (modified cellulose such as methylcellulose and psyllium). | Viscous fibers thicken the contents of the intestinal tract and may attenuate the absorption of sugar, reduce sugar response after eating, and reduce lipid absorption (notably shown with cholesterol absorption). Their use in food formulations is often limited to low levels, due to their viscosity and thickening effects. Some viscous fibers may also be partially or fully fermented within the intestinal tract (guar gum, beta-glucan, glucomannan and pectins), but some viscous fibers are minimally or not fermented (modified cellulose such as methylcellulose and psyllium). | ||
Fermentable fibers are consumed by the [[gut flora|microbiota]] within the large intestines, mildly increasing fecal bulk and producing [[short-chain fatty acids]] as byproducts with wide-ranging physiological activities. [[Resistant starch]], [[inulin]], [[fructooligosaccharide]] and [[galactooligosaccharide]] are dietary fibers which are fully fermented. These include insoluble as well as soluble fibers. This fermentation influences the expression of many genes within the large intestine, | Fermentable fibers are consumed by the [[gut flora|microbiota]] within the large intestines, mildly increasing fecal bulk and producing [[short-chain fatty acids]] as byproducts with wide-ranging physiological activities. [[Resistant starch]], [[inulin]], [[fructooligosaccharide]] and [[galactooligosaccharide]] are dietary fibers which are fully fermented. These include insoluble as well as soluble fibers. This fermentation influences the expression of many genes within the large intestine, which affect digestive function and lipid and glucose metabolism, as well as the immune system, inflammation and more. | ||
Fiber fermentation produces gas (majorly carbon dioxide, hydrogen, and methane) and [[short-chain fatty acids]]. Isolated or purified fermentable fibers are more rapidly fermented in the fore-gut and may result in undesirable gastrointestinal symptoms ([[bloating]], [[indigestion]] and [[flatulence]]). | Fiber fermentation produces gas (majorly carbon dioxide, hydrogen, and methane) and [[short-chain fatty acids]]. Isolated or purified fermentable fibers are more rapidly fermented in the fore-gut and may result in undesirable gastrointestinal symptoms ([[bloating]], [[indigestion]] and [[flatulence]]). | ||
Dietary fibers can change the nature of the contents of the [[gastrointestinal tract]] and can change how other nutrients and chemicals are absorbed through bulking and viscosity. | Dietary fibers can change the nature of the contents of the [[gastrointestinal tract]] and can change how other nutrients and chemicals are absorbed through bulking and viscosity. Some types of soluble fibers bind to [[bile acids]] in the small intestine, making them less likely to re-enter the body; this in turn lowers [[cholesterol]] levels in the blood from the actions of [[cytochrome P450]]-mediated oxidation of cholesterol. | ||
Insoluble fiber is associated with reduced risk of diabetes, | Insoluble fiber is associated with reduced risk of diabetes, but the mechanism by which this is achieved is unknown. One type of insoluble dietary fiber, [[resistant starch]], may increase insulin sensitivity in healthy people, in type 2 diabetics, and in individuals with insulin resistance, possibly contributing to reduced risk of type 2 diabetes. | ||
Not yet formally proposed as an essential [[macronutrient]], dietary fiber has importance in the diet, with regulatory authorities in many developed countries recommending increases in fiber intake. | Not yet formally proposed as an essential [[macronutrient]], dietary fiber has importance in the diet, with regulatory authorities in many developed countries recommending increases in fiber intake. | ||
===Physicochemical properties=== | ===Physicochemical properties=== | ||
Dietary fiber has distinct [[physical chemistry|physicochemical]] properties. Most semi-solid foods, fiber and fat are a combination of gel matrices which are hydrated or collapsed with microstructural elements, globules, solutions or encapsulating walls. Fresh fruit and vegetables are cellular materials. | Dietary fiber has distinct [[physical chemistry|physicochemical]] properties. Most semi-solid foods, fiber and fat are a combination of gel matrices which are hydrated or collapsed with microstructural elements, globules, solutions or encapsulating walls. Fresh fruit and vegetables are cellular materials. | ||
* The cells of cooked potatoes and legumes are gels filled with gelatinized starch granules. The cellular structures of fruits and vegetables are foams with a closed cell geometry filled with a gel, surrounded by cell walls which are composites with an amorphous matrix strengthened by complex carbohydrate fibers. | * The cells of cooked potatoes and legumes are gels filled with gelatinized starch granules. The cellular structures of fruits and vegetables are foams with a closed cell geometry filled with a gel, surrounded by cell walls which are composites with an amorphous matrix strengthened by complex carbohydrate fibers. | ||
* Particle size and interfacial interactions with adjacent matrices affect the mechanical properties of food composites. | * Particle size and interfacial interactions with adjacent matrices affect the mechanical properties of food composites. | ||
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* The variables include chemical structure, polymer concentration, molecular weight, degree of chain branching, the extent of ionization (for electrolytes), solution pH, ionic strength and temperature. | * The variables include chemical structure, polymer concentration, molecular weight, degree of chain branching, the extent of ionization (for electrolytes), solution pH, ionic strength and temperature. | ||
* Cross-linking of different polymers, protein and polysaccharides, either through chemical covalent bonds or cross-links through molecular entanglement or hydrogen or ionic bond cross-linking. | * Cross-linking of different polymers, protein and polysaccharides, either through chemical covalent bonds or cross-links through molecular entanglement or hydrogen or ionic bond cross-linking. | ||
* Cooking and chewing food alters these physicochemical properties and hence absorption and movement through the stomach and along the intestine | * Cooking and chewing food alters these physicochemical properties and hence absorption and movement through the stomach and along the intestine | ||
===Upper gastrointestinal tract=== | ===Upper gastrointestinal tract=== | ||
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* complex lipids/[[micelles|micellar]]/[[aqueous]]/[[hydrocolloid]] and [[hydrophobic]] phases | * complex lipids/[[micelles|micellar]]/[[aqueous]]/[[hydrocolloid]] and [[hydrophobic]] phases | ||
* [[hydrophilic]] phases | * [[hydrophilic]] phases | ||
* solid, liquid, colloidal and gas bubble phases. | * solid, liquid, colloidal and gas bubble phases. | ||
[[Micelle]]s are colloid-sized clusters of molecules which form in conditions as those above, similar to the critical micelle concentration of detergents. | [[Micelle]]s are colloid-sized clusters of molecules which form in conditions as those above, similar to the critical micelle concentration of detergents. | ||
In the upper gastrointestinal tract, these compounds consist of bile acids and di- and monoacyl [[glycerol]]s which solubilize [[triacylglycerol]]s and cholesterol. | In the upper gastrointestinal tract, these compounds consist of bile acids and di- and monoacyl [[glycerol]]s which solubilize [[triacylglycerol]]s and cholesterol. | ||
Two mechanisms bring nutrients into contact with the epithelium: | Two mechanisms bring nutrients into contact with the epithelium: | ||
# intestinal contractions create turbulence; and | # intestinal contractions create turbulence; and | ||
# convection currents direct contents from the [[lumen (anatomy)|lumen]] to the epithelial surface. | # convection currents direct contents from the [[lumen (anatomy)|lumen]] to the epithelial surface. | ||
The multiple physical phases in the intestinal tract slow the rate of absorption compared to that of the suspension solvent alone. | The multiple physical phases in the intestinal tract slow the rate of absorption compared to that of the suspension solvent alone. | ||
# Nutrients diffuse through the thin, relatively unstirred layer of fluid adjacent to the epithelium. | # Nutrients diffuse through the thin, relatively unstirred layer of fluid adjacent to the epithelium. | ||
# Immobilizing of nutrients and other chemicals within complex polysaccharide molecules affects their release and subsequent absorption from the small intestine, an effect influential on the [[glycemic index]]. | # Immobilizing of nutrients and other chemicals within complex polysaccharide molecules affects their release and subsequent absorption from the small intestine, an effect influential on the [[glycemic index]]. | ||
# Molecules begin to interact as their concentration increases. During absorption, water must be absorbed at a rate commensurate with the absorption of solutes. The transport of actively and passively absorbed nutrients across epithelium is affected by the unstirred water layer covering the [[microvillus]] membrane. | # Molecules begin to interact as their concentration increases. During absorption, water must be absorbed at a rate commensurate with the absorption of solutes. The transport of actively and passively absorbed nutrients across epithelium is affected by the unstirred water layer covering the [[microvillus]] membrane. | ||
# The presence of mucus or fiber, e.g., pectin or guar, in the unstirred layer may alter the viscosity and solute diffusion coefficient. | # The presence of mucus or fiber, e.g., pectin or guar, in the unstirred layer may alter the viscosity and solute diffusion coefficient. | ||
Adding viscous polysaccharides to carbohydrate meals can reduce [[post-prandial]] blood glucose concentrations. Wheat and maize but not oats modify glucose absorption, the rate being dependent upon the particle size. The reduction in absorption rate with guar gum may be due to the increased resistance by viscous solutions to the convective flows created by intestinal contractions. | Adding viscous polysaccharides to carbohydrate meals can reduce [[post-prandial]] blood glucose concentrations. Wheat and maize but not oats modify glucose absorption, the rate being dependent upon the particle size. The reduction in absorption rate with guar gum may be due to the increased resistance by viscous solutions to the convective flows created by intestinal contractions. | ||
Dietary fiber interacts with pancreatic and enteric enzymes and their substrates. Human pancreatic enzyme activity is reduced when incubated with most fiber sources. Fiber may affect [[amylase]] activity and hence the rate of hydrolysis of starch. The more viscous polysaccharides extend the mouth-to-[[cecum]] transit time; guar, [[tragacanth]] and pectin being slower than wheat bran. | Dietary fiber interacts with pancreatic and enteric enzymes and their substrates. Human pancreatic enzyme activity is reduced when incubated with most fiber sources. Fiber may affect [[amylase]] activity and hence the rate of hydrolysis of starch. The more viscous polysaccharides extend the mouth-to-[[cecum]] transit time; guar, [[tragacanth]] and pectin being slower than wheat bran. | ||
===Colon=== | ===Colon=== | ||
The colon may be regarded as two organs, | The colon may be regarded as two organs, | ||
# the right side ([[cecum]] and [[Large intestine#Ascending colon|ascending colon]]), a [[Fermentation|fermenter]]. | # the right side ([[cecum]] and [[Large intestine#Ascending colon|ascending colon]]), a [[Fermentation|fermenter]]. The right side of the colon is involved in nutrient salvage so that dietary fiber, resistant starch, fat and protein are utilized by bacteria and the end-products absorbed for use by the body | ||
# the left side ([[Large intestine#Transverse colon|transverse]], [[Large intestine#Descending colon|descending]], and [[Large intestine#Sigmoid colon|sigmoid colon]]), affecting continence. | # the left side ([[Large intestine#Transverse colon|transverse]], [[Large intestine#Descending colon|descending]], and [[Large intestine#Sigmoid colon|sigmoid colon]]), affecting continence. | ||
The presence of bacteria in the colon produces an 'organ' of intense, mainly reductive, metabolic activity, whereas the liver is oxidative. | The presence of bacteria in the colon produces an 'organ' of intense, mainly reductive, metabolic activity, whereas the liver is oxidative. | ||
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===Cholesterol metabolism=== | ===Cholesterol metabolism=== | ||
Dietary fiber may act on each phase of ingestion, digestion, absorption and excretion to affect cholesterol metabolism, | Dietary fiber may act on each phase of ingestion, digestion, absorption and excretion to affect cholesterol metabolism, such as the following: | ||
# Caloric energy of foods through a bulking effect | # Caloric energy of foods through a bulking effect | ||
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# Binding of bile acids to fiber or bacteria in the cecum with increased fecal loss from the entero-hepatic circulation. | # Binding of bile acids to fiber or bacteria in the cecum with increased fecal loss from the entero-hepatic circulation. | ||
One action of some fibers is to reduce the reabsorption of bile acids in the ileum and hence the amount and type of bile acid and fats reaching the colon. A reduction in the reabsorption of bile acid from the ileum has several direct effects. | One action of some fibers is to reduce the reabsorption of bile acids in the ileum and hence the amount and type of bile acid and fats reaching the colon. A reduction in the reabsorption of bile acid from the ileum has several direct effects. | ||
# Bile acids may be trapped within the lumen of the ileum either because of a high luminal viscosity or because of binding to a dietary fiber. | # Bile acids may be trapped within the lumen of the ileum either because of a high luminal viscosity or because of binding to a dietary fiber. | ||
# Lignin in fiber adsorbs bile acids, but the unconjugated form of the bile acids are adsorbed more than the conjugated form. In the ileum where bile acids are primarily absorbed the bile acids are predominantly conjugated. | # Lignin in fiber adsorbs bile acids, but the unconjugated form of the bile acids are adsorbed more than the conjugated form. In the ileum where bile acids are primarily absorbed the bile acids are predominantly conjugated. | ||
# The enterohepatic circulation of bile acids may be altered and there is an increased flow of bile acids to the cecum, where they are deconjugated and 7alpha-dehydroxylated. | # The enterohepatic circulation of bile acids may be altered and there is an increased flow of bile acids to the cecum, where they are deconjugated and 7alpha-dehydroxylated. | ||
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The fibers that are most effective in influencing sterol metabolism (e.g. pectin) are fermented in the colon. It is therefore unlikely that the reduction in body cholesterol is due to adsorption to this fermented fiber in the colon. | The fibers that are most effective in influencing sterol metabolism (e.g. pectin) are fermented in the colon. It is therefore unlikely that the reduction in body cholesterol is due to adsorption to this fermented fiber in the colon. | ||
# There might be alterations in the end-products of bile acid bacterial metabolism or the release of short chain fatty acids which are absorbed from the colon, return to the liver in the portal vein and modulate either the synthesis of cholesterol or its catabolism to bile acids. | # There might be alterations in the end-products of bile acid bacterial metabolism or the release of short chain fatty acids which are absorbed from the colon, return to the liver in the portal vein and modulate either the synthesis of cholesterol or its catabolism to bile acids. | ||
# The prime mechanism whereby fiber influences cholesterol metabolism is through bacteria binding bile acids in the colon after the initial deconjugation and dehydroxylation. The sequestered bile acids are then excreted in feces. | # The prime mechanism whereby fiber influences cholesterol metabolism is through bacteria binding bile acids in the colon after the initial deconjugation and dehydroxylation. The sequestered bile acids are then excreted in feces. | ||
# Fermentable fibers e.g., pectin will increase the bacterial mass in the colon by virtue of their providing a medium for bacterial growth. | # Fermentable fibers e.g., pectin will increase the bacterial mass in the colon by virtue of their providing a medium for bacterial growth. | ||
# Other fibers, e.g., [[gum arabic]], act as [[Food additive#Categories|stabilizers]] and cause a significant decrease in serum cholesterol without increasing fecal bile acid excretion. | # Other fibers, e.g., [[gum arabic]], act as [[Food additive#Categories|stabilizers]] and cause a significant decrease in serum cholesterol without increasing fecal bile acid excretion. | ||
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Preliminary research indicates that fiber may affect health by different mechanisms. | Preliminary research indicates that fiber may affect health by different mechanisms. | ||
Effects of fiber include: | Effects of fiber include: | ||
*Increases food volume without increasing caloric content to the same extent as digestible carbohydrates, providing satiety which may reduce appetite (both insoluble and soluble fiber) | *Increases food volume without increasing caloric content to the same extent as digestible carbohydrates, providing satiety which may reduce appetite (both insoluble and soluble fiber) | ||
*Attracts water and forms a [[viscosity|viscous]] gel during digestion, slowing the emptying of the stomach, shortening intestinal transit time, shielding carbohydrates from enzymes, and delaying absorption of glucose, | *Attracts water and forms a [[viscosity|viscous]] gel during digestion, slowing the emptying of the stomach, shortening intestinal transit time, shielding carbohydrates from enzymes, and delaying absorption of glucose, which lowers variance in blood sugar levels (soluble fiber) | ||
*Lowers total and LDL cholesterol, which may reduce the risk of cardiovascular disease | *Lowers total and LDL cholesterol, which may reduce the risk of cardiovascular disease (soluble fiber) | ||
*Regulates blood sugar, which may reduce glucose and insulin levels in diabetic patients and may lower risk of diabetes | *Regulates blood sugar, which may reduce glucose and insulin levels in diabetic patients and may lower risk of diabetes (insoluble fiber) | ||
*Speeds the passage of foods through the digestive system, which facilitates regular defecation (insoluble fiber) | *Speeds the passage of foods through the digestive system, which facilitates regular defecation (insoluble fiber) | ||
*Adds bulk to the stool, which alleviates constipation (insoluble fiber) | *Adds bulk to the stool, which alleviates constipation (insoluble fiber) | ||
*Balances intestinal pH | *Balances intestinal pH and stimulates intestinal fermentation production of short-chain fatty acids (both insoluble and soluble fiber) | ||
Fiber does not bind to minerals and vitamins and therefore does not restrict their absorption, but rather evidence exists that fermentable fiber sources improve absorption of minerals, especially calcium. | Fiber does not bind to minerals and vitamins and therefore does not restrict their absorption, but rather evidence exists that fermentable fiber sources improve absorption of minerals, especially calcium. | ||
===Research=== | ===Research=== | ||
As of 2019, preliminary [[clinical research]] on the potential health effects of a regular high-fiber diet included studies on the risk of several [[cancer]]s, [[cardiovascular disease]]s, and [[type II diabetes]]. | As of 2019, preliminary [[clinical research]] on the potential health effects of a regular high-fiber diet included studies on the risk of several [[cancer]]s, [[cardiovascular disease]]s, and [[type II diabetes]]. | ||
A 2011 study of 388,000 adults ages 50 to 71 for nine years found that the highest consumers of fiber were 22% less likely to die over this period. | A 2011 study of 388,000 adults ages 50 to 71 for nine years found that the highest consumers of fiber were 22% less likely to die over this period. In addition to lower risk of death from heart disease, adequate consumption of fiber-containing foods, especially grains, was also correlated with reduced incidence of infectious and respiratory illnesses, and, particularly among males, reduced risk of [[cancer]]-related death. | ||
A study of over 88,000 women did not show a statistically significant relationship between higher fiber consumption and lower rates of [[colorectal cancer]] or [[adenoma]]s. | A study of over 88,000 women did not show a statistically significant relationship between higher fiber consumption and lower rates of [[colorectal cancer]] or [[adenoma]]s. A 2010 study of 58,279 men found no relationship between dietary fiber and colorectal cancer. | ||
An extensive article exploring the link between dietary fiber and inflammatory bowel disease (IBD) described that dietary fiber has significant health benefits for IBD patients [[doi:10.3390/biomedicines10061242|117]] | An extensive article exploring the link between dietary fiber and inflammatory bowel disease (IBD) described that dietary fiber has significant health benefits for IBD patients [[doi:10.3390/biomedicines10061242|117]] | ||
A 2022 study over 20 years of Japanese adults aged 40–64 years showed a possible [[inverse relationship]] between the intake of soluble fiber and the risk of developing [[dementia]] during aging. | A 2022 study over 20 years of Japanese adults aged 40–64 years showed a possible [[inverse relationship]] between the intake of soluble fiber and the risk of developing [[dementia]] during aging. | ||
==Dietary recommendations== | ==Dietary recommendations== | ||
===European Union=== | ===European Union=== | ||
According to the [[European Food Safety Authority]] (EFSA) Panel on Nutrition, Novel Foods and Food Allergens (NDA), which deals with the establishment of Dietary Reference Values for carbohydrates and dietary fibre, "based on the available evidence on bowel function, the Panel considers dietary fibre intakes of 25 g per day to be adequate for normal laxation in adults". | According to the [[European Food Safety Authority]] (EFSA) Panel on Nutrition, Novel Foods and Food Allergens (NDA), which deals with the establishment of Dietary Reference Values for carbohydrates and dietary fibre, "based on the available evidence on bowel function, the Panel considers dietary fibre intakes of 25 g per day to be adequate for normal laxation in adults". | ||
===United States=== | ===United States=== | ||
Current recommendations from the United States [[National Academy of Medicine]] (NAM) (formerly Institute of Medicine) of the [[National Academy of Sciences]] state that for [[Dietary Reference Intake|Adequate Intake]], adult men ages 19–50 consume 38 grams of dietary fiber per day, men 51 and older 30 grams, women ages 19–50 to consume 25 grams per day, women 51 and older 21 grams. These are based on three studies observing that people in the highest quintile of fiber intake consumed a median of 14 grams of fiber per 1,000 Calories and had the lowest risk of coronary heart disease, especially for those who ate more cereal fiber. | Current recommendations from the United States [[National Academy of Medicine]] (NAM) (formerly Institute of Medicine) of the [[National Academy of Sciences]] state that for [[Dietary Reference Intake|Adequate Intake]], adult men ages 19–50 consume 38 grams of dietary fiber per day, men 51 and older 30 grams, women ages 19–50 to consume 25 grams per day, women 51 and older 21 grams. These are based on three studies observing that people in the highest quintile of fiber intake consumed a median of 14 grams of fiber per 1,000 Calories and had the lowest risk of coronary heart disease, especially for those who ate more cereal fiber. | ||
The United States [[Academy of Nutrition and Dietetics]] (AND, previously ADA) reiterates the recommendations of the NAM. | The United States [[Academy of Nutrition and Dietetics]] (AND, previously ADA) reiterates the recommendations of the NAM. A 1995 research team's recommendation for children is that intake should equal age in years plus 5 g/day (e.g., a 4-year-old should consume 9 g/day). The NAM's current recommendation for children is 19 g/day for age 1-3 years and 25 g/day for age 4-8 years. No guidelines have yet been established for the elderly or very ill. Patients with current [[constipation]], [[vomiting]], and [[abdominal pain]] should see a physician. Certain bulking agents are not commonly recommended with the prescription of [[opioid]]s because the slow transit time mixed with larger stools may lead to severe constipation, pain, or obstruction. | ||
On average, North Americans consume less than 50% of the dietary fiber levels recommended for good health. In the preferred food choices of today's youth, this value may be as low as 20%, a factor considered by experts as contributing to the [[obesity]] levels seen in many [[developed countries]]. | On average, North Americans consume less than 50% of the dietary fiber levels recommended for good health. In the preferred food choices of today's youth, this value may be as low as 20%, a factor considered by experts as contributing to the [[obesity]] levels seen in many [[developed countries]]. Recognizing the growing scientific evidence for physiological benefits of increased fiber intake, regulatory agencies such as the [[Food and Drug Administration (United States)|Food and Drug Administration]] (FDA) of the United States have given approvals to food products making health claims for fiber. The FDA classifies which ingredients qualify as being "fiber", and requires for product labeling that a physiological benefit is gained by adding the fiber ingredient. As of 2008, the FDA approved [[health claim]]s for qualified fiber products to display labeling that regular consumption may reduce [[blood cholesterol]] levels – which can lower the risk of [[coronary heart disease]] – and also reduce the risk of some types of cancer. | ||
Viscous fiber sources gaining FDA approval are: | Viscous fiber sources gaining FDA approval are: | ||
* [[Psyllium]] seed husk (7 grams per day) | * [[Psyllium]] seed husk (7 grams per day) | ||
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Other examples of bulking fiber sources used in [[functional food]]s and supplements include [[cellulose]], [[guar gum]] and [[xanthan gum]]. Other examples of fermentable fiber sources (from plant foods or biotechnology) used in functional foods and supplements include [[resistant starch]], [[inulin]], [[fructan]]s, fructooligo saccharides, oligo- or polysaccharides, and resistant [[dextrin]]s, which may be partially or fully fermented. | Other examples of bulking fiber sources used in [[functional food]]s and supplements include [[cellulose]], [[guar gum]] and [[xanthan gum]]. Other examples of fermentable fiber sources (from plant foods or biotechnology) used in functional foods and supplements include [[resistant starch]], [[inulin]], [[fructan]]s, fructooligo saccharides, oligo- or polysaccharides, and resistant [[dextrin]]s, which may be partially or fully fermented. | ||
Consistent intake of fermentable fiber may reduce the risk of chronic diseases. | Consistent intake of fermentable fiber may reduce the risk of chronic diseases. Insufficient fiber in the diet can lead to [[constipation]]. | ||
===United Kingdom=== | ===United Kingdom=== | ||
In 2018, the [[British Nutrition Foundation]] issued a statement to define dietary fiber more concisely and list the potential health benefits established to date, while increasing its recommended daily minimum intake to 30 grams for healthy adults. | In 2018, the [[British Nutrition Foundation]] issued a statement to define dietary fiber more concisely and list the potential health benefits established to date, while increasing its recommended daily minimum intake to 30 grams for healthy adults. Statement: 'Dietary fibre' has been used as a collective term for a complex mixture of substances with different chemical and physical properties which exert different types of physiological effects. | ||
The use of certain analytical methods to quantify dietary fiber by nature of its indigestin ability results in many other indigestible components being isolated along with the [[carbohydrate]] components of dietary fiber. These components include resistant starches and [[oligosaccharide|oligo saccharide]]s along with other substances that exist within the plant cell structure and contribute to the material that passes through the digestive tract. Such components are likely to have physiological effects. | The use of certain analytical methods to quantify dietary fiber by nature of its indigestin ability results in many other indigestible components being isolated along with the [[carbohydrate]] components of dietary fiber. These components include resistant starches and [[oligosaccharide|oligo saccharide]]s along with other substances that exist within the plant cell structure and contribute to the material that passes through the digestive tract. Such components are likely to have physiological effects. | ||
Diets naturally high in fiber can be considered to bring about several main physiological consequences: | Diets naturally high in fiber can be considered to bring about several main physiological consequences: | ||
* increases [[fecal]] bulk and helps prevent [[constipation]] by decreasing fecal transit time in the [[large intestine]] | * increases [[fecal]] bulk and helps prevent [[constipation]] by decreasing fecal transit time in the [[large intestine]] | ||
* improves [[human gastrointestinal tract|gastro-intestinal]] health | * improves [[human gastrointestinal tract|gastro-intestinal]] health | ||
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* increases [[satiety]] and hence may contribute to weight management | * increases [[satiety]] and hence may contribute to weight management | ||
Fiber is defined by its physiological impact, with many heterogenous types of fibers. Some fibers may primarily impact one of these benefits (i.e., cellulose increases fecal bulking and prevents constipation), but many fibers impact more than one of these benefits (i.e., [[resistant starch]] increases bulking, increases colonic fermentation, positively modulates colonic microflora and increases satiety and insulin sensitivity). | Fiber is defined by its physiological impact, with many heterogenous types of fibers. Some fibers may primarily impact one of these benefits (i.e., cellulose increases fecal bulking and prevents constipation), but many fibers impact more than one of these benefits (i.e., [[resistant starch]] increases bulking, increases colonic fermentation, positively modulates colonic microflora and increases satiety and insulin sensitivity). The beneficial effects of high fiber diets are the summation of the effects of the different types of fiber present in the diet and also other components of such diets. | ||
Defining fiber physiologically allows recognition of indigestible carbohydrates with structures and physiological properties similar to those of naturally occurring dietary fibers. | Defining fiber physiologically allows recognition of indigestible carbohydrates with structures and physiological properties similar to those of naturally occurring dietary fibers. | ||
==Fermentation== | ==Fermentation== | ||
The [[American Association of Cereal Chemists|Cereals & Grains Association]] has defined soluble fiber this way: | The [[American Association of Cereal Chemists|Cereals & Grains Association]] has defined soluble fiber this way: | ||
"the edible parts of plants or similar carbohydrates resistant to digestion and absorption in the human small intestine with complete or partial fermentation in the large intestine." | "the edible parts of plants or similar carbohydrates resistant to digestion and absorption in the human small intestine with complete or partial fermentation in the large intestine." | ||
In this definition, "edible parts of plants" indicates that some parts of a plant that are eaten—skin, pulp, seeds, stems, leaves, roots—contain fiber. Both insoluble and soluble sources are in those plant components. "Carbohydrates" refers to complex carbohydrates, such as long-chained sugars also called [[starch]], [[oligosaccharide|oligo saccharide]]s, or [[polysaccharide|poly saccharide]]s, which are sources of soluble fermentable fiber. "Resistant to digestion and absorption in the human small intestine" refers to compounds that are not digested by [[gastric acid]] and [[digestive enzymes]] in the stomach and small intestine, preventing the digesting animal from utilizing the compounds for energy. A food resistant to this process is undigested, as insoluble and soluble fibers are. They pass to the large intestine only affected by their absorption of water (insoluble fiber) or dissolution in water (soluble fiber). "Complete or partial fermentation in the large intestine" describes the digestive processes of the large intestine, which comprises a segment called the [[Colon (anatomy)|colon]] within which additional nutrient absorption occurs through the process of fermentation. Fermentation occurs through the action of colonic bacteria on the food mass, producing gases and short-chain fatty acids. These short-chain fatty acids have been shown to have significant health properties. | In this definition, "edible parts of plants" indicates that some parts of a plant that are eaten—skin, pulp, seeds, stems, leaves, roots—contain fiber. Both insoluble and soluble sources are in those plant components. "Carbohydrates" refers to complex carbohydrates, such as long-chained sugars also called [[starch]], [[oligosaccharide|oligo saccharide]]s, or [[polysaccharide|poly saccharide]]s, which are sources of soluble fermentable fiber. "Resistant to digestion and absorption in the human small intestine" refers to compounds that are not digested by [[gastric acid]] and [[digestive enzymes]] in the stomach and small intestine, preventing the digesting animal from utilizing the compounds for energy. A food resistant to this process is undigested, as insoluble and soluble fibers are. They pass to the large intestine only affected by their absorption of water (insoluble fiber) or dissolution in water (soluble fiber). "Complete or partial fermentation in the large intestine" describes the digestive processes of the large intestine, which comprises a segment called the [[Colon (anatomy)|colon]] within which additional nutrient absorption occurs through the process of fermentation. Fermentation occurs through the action of colonic bacteria on the food mass, producing gases and short-chain fatty acids. These short-chain fatty acids have been shown to have significant health properties. They include [[butyric acid|butyric]], [[acetic acid|acetic]] (ethanoic), [[propionic acid|propionic]], and [[valeric acid|valeric]] acids. | ||
As an example of fermentation, shorter-chain carbohydrates (a type of fiber found in legumes) cannot be digested, but are changed via fermentation in the colon into short-chain [[fatty acid]]s and gases (which are typically expelled as [[flatulence]]). | As an example of fermentation, shorter-chain carbohydrates (a type of fiber found in legumes) cannot be digested, but are changed via fermentation in the colon into short-chain [[fatty acid]]s and gases (which are typically expelled as [[flatulence]]). | ||
According to a 2002 journal article, | According to a 2002 journal article, | ||
fiber compounds with partial or low fermentability include: | fiber compounds with partial or low fermentability include: | ||
* [[cellulose]], a [[polysaccharide|poly-saccharide]] | * [[cellulose]], a [[polysaccharide|poly-saccharide]] | ||
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==Short-chain fatty acids== | ==Short-chain fatty acids== | ||
When fermentable fiber is fermented, [[short-chain fatty acid]]s (SCFA) are produced. | When fermentable fiber is fermented, [[short-chain fatty acid]]s (SCFA) are produced. SCFAs are involved in numerous physiological processes promoting health, including: | ||
* stabilize blood [[glucose]] levels by acting on pancreatic [[insulin]] release and liver control of [[glycogen]] breakdown | * stabilize blood [[glucose]] levels by acting on pancreatic [[insulin]] release and liver control of [[glycogen]] breakdown | ||
* stimulate [[gene expression]] of [[glucose transporter]]s in the [[intestinal mucosa]], regulating glucose absorption | * stimulate [[gene expression]] of [[glucose transporter]]s in the [[intestinal mucosa]], regulating glucose absorption | ||
* provide nourishment of colonocytes, particularly by the SCFA butyrate | * provide nourishment of colonocytes, particularly by the SCFA butyrate | ||
* suppress [[cholesterol]] synthesis by the liver and reduce blood levels of [[Low-density lipoprotein|LDL cholesterol]] and [[triglyceride]]s responsible for [[atherosclerosis]] | * suppress [[cholesterol]] synthesis by the liver and reduce blood levels of [[Low-density lipoprotein|LDL cholesterol]] and [[triglyceride]]s responsible for [[atherosclerosis]] | ||
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SCFAs that are absorbed by the colonic mucosa pass through the colonic wall into the [[portal circulation]] (supplying the [[liver]]), and the liver transports them into the general [[circulatory system]]. | SCFAs that are absorbed by the colonic mucosa pass through the colonic wall into the [[portal circulation]] (supplying the [[liver]]), and the liver transports them into the general [[circulatory system]]. | ||
Overall, SCFAs affect major regulatory systems, such as blood glucose and lipid levels, the colonic environment, and intestinal immune functions. | Overall, SCFAs affect major regulatory systems, such as blood glucose and lipid levels, the colonic environment, and intestinal immune functions. | ||
The major SCFAs in humans are [[butyric acid|butyrate]], [[propionic acid|propionate]], and [[acetic acid|acetate]], where butyrate is the major energy source for [[colon (anatomy)|colonocytes]], propionate is destined for uptake by the liver, and acetate enters the peripheral circulation to be metabolized by peripheral tissues. | The major SCFAs in humans are [[butyric acid|butyrate]], [[propionic acid|propionate]], and [[acetic acid|acetate]], where butyrate is the major energy source for [[colon (anatomy)|colonocytes]], propionate is destined for uptake by the liver, and acetate enters the peripheral circulation to be metabolized by peripheral tissues. | ||
==FDA-approved health claims== | ==FDA-approved health claims== | ||
The United States FDA allows manufacturers of foods containing 1.7 g per serving of psyllium husk soluble fiber or 0.75 g of [[oat]] or [[barley]] soluble fiber as [[beta-glucans]] to [[health claim|claim]] that regular consumption may reduce the risk of [[heart disease]]. | The United States FDA allows manufacturers of foods containing 1.7 g per serving of psyllium husk soluble fiber or 0.75 g of [[oat]] or [[barley]] soluble fiber as [[beta-glucans]] to [[health claim|claim]] that regular consumption may reduce the risk of [[heart disease]]. | ||
The FDA statement template for making this claim is: | The FDA statement template for making this claim is: | ||
{{Quote|Soluble fiber from foods such as [name of soluble fiber source, and, if desired, name of food product], as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. A serving of [name of food product] supplies __ grams of the [necessary daily dietary intake for the benefit] soluble fiber from [name of soluble fiber source] necessary per day to have this effect. | {{Quote|Soluble fiber from foods such as [name of soluble fiber source, and, if desired, name of food product], as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. A serving of [name of food product] supplies __ grams of the [necessary daily dietary intake for the benefit] soluble fiber from [name of soluble fiber source] necessary per day to have this effect.}} | ||
Eligible sources of soluble fiber providing beta-glucan include: | Eligible sources of soluble fiber providing beta-glucan include: | ||
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* 3 g or more per day of beta-glucan soluble fiber from either whole oats or barley, or a combination of whole oats and barley | * 3 g or more per day of beta-glucan soluble fiber from either whole oats or barley, or a combination of whole oats and barley | ||
* 7 g or more per day of soluble fiber from psyllium seed husk. | * 7 g or more per day of soluble fiber from psyllium seed husk. | ||
Soluble fiber from consuming grains is included in other allowed health claims for lowering risk of some types of cancer and heart disease by consuming fruit and vegetables (21 CFR 101.76, 101.77, and 101.78). | Soluble fiber from consuming grains is included in other allowed health claims for lowering risk of some types of cancer and heart disease by consuming fruit and vegetables (21 CFR 101.76, 101.77, and 101.78). | ||
In December 2016, FDA approved a qualified health claim that consuming resistant starch from high-[[amylose]] corn may reduce the risk of [[type 2 diabetes]] due to its effect of increasing [[insulin sensitivity]]. The allowed claim specified: "High-amylose maize [[resistant starch]] may reduce the risk of [[type 2 diabetes]]. FDA has concluded that there is limited scientific evidence for this claim." | In December 2016, FDA approved a qualified health claim that consuming resistant starch from high-[[amylose]] corn may reduce the risk of [[type 2 diabetes]] due to its effect of increasing [[insulin sensitivity]]. The allowed claim specified: "High-amylose maize [[resistant starch]] may reduce the risk of [[type 2 diabetes]]. FDA has concluded that there is limited scientific evidence for this claim." In 2018, the FDA released further guidance on the labeling of isolated or synthetic dietary fiber to clarify how different types of dietary fiber should be classified. | ||
==See also== | ==See also== | ||
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* {{annotated link|List of phytochemicals in food}} | * {{annotated link|List of phytochemicals in food}} | ||
* {{annotated link|Low-fiber/low-residue diet}} | * {{annotated link|Low-fiber/low-residue diet}} | ||
==Further reading== | ==Further reading== | ||