Febuxostat/ja: Difference between revisions
Febuxostat/ja
Created page with "| legal_AU = S4 | legal_AU_comment = | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> | legal_US = Rx-only | legal_EU = Rx-only | legal_status =" Tags: Mobile edit Mobile web edit |
Created page with "<!-- Identifiers --> | IUPHAR_ligand = 6817 | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 144060-53-7 | PubChem = 134018 | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = DB04854 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 118173 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 101V0R1N2E | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D01206 | ChEBI = 31596 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1164729" Tags: Mobile edit Mobile web edit |
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| legal_status = | | legal_status = | ||
<!-- Pharmacokinetic data --> | <!-- Pharmacokinetic data --> | ||
| bioavailability = ≥84% absorbed | | bioavailability = ≥84% absorbed | ||
| protein_bound = 99.2% to albumin | | protein_bound = 99.2% to albumin | ||
| metabolism = via [[CYP1A1]], [[CYP1A2|1A2]], [[CYP2C8|2C8]], [[CYP2C9|2C9]], [[UGT1A1]], [[UGT1A8|1A8]], [[UGT1A9|1A9]] | | metabolism = via [[CYP1A1/ja]], [[CYP1A2/ja|1A2]], [[CYP2C8/ja|2C8]], [[CYP2C9/ja|2C9]], [[UGT1A1/ja]], [[UGT1A8/ja|1A8]], [[UGT1A9/ja|1A9]] | ||
| elimination_half-life = ~5–8 hours | | elimination_half-life = ~5–8 hours | ||
| excretion = | | excretion = 尿（～49％、大部分は代謝物として、3％は未変化体として）；糞便（～45％、大部分は代謝物として、12％は未変化体として） | ||
<!-- Identifiers --> | <!-- Identifiers --> | ||
| IUPHAR_ligand = 6817 | | IUPHAR_ligand = 6817 | ||
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| ChEMBL_Ref = {{ebicite|correct|EBI}} | | ChEMBL_Ref = {{ebicite|correct|EBI}} | ||
| ChEMBL = 1164729 | | ChEMBL = 1164729 | ||
<!-- Chemical data --> | <!-- Chemical data --> | ||
| IUPAC_name = 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-<br />1,3-thiazole-5-carboxylic acid | | IUPAC_name = 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-<br />1,3-thiazole-5-carboxylic acid | ||
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| StdInChIKey = BQSJTQLCZDPROO-UHFFFAOYSA-N | | StdInChIKey = BQSJTQLCZDPROO-UHFFFAOYSA-N | ||
}} | }} | ||
<div lang="en" dir="ltr" class="mw-content-ltr"> | <div lang="en" dir="ltr" class="mw-content-ltr"> | ||