Prosultiamine: Difference between revisions
Created page with "<languages /> <translate> {{Short description|Chemical compound}} {{Drugbox | IUPAC_name = ''N''-[(4-amino-2-methylpyrimidin-5-yl)methyl]-''N''-[(1''E'')-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide | image = Prosultiamine.png | alt = Skeletal formula of prosultiamine | width = 240 | image2 = Prosultiamine 3D ball.png | alt2 = Ball-and-stick model of the prosultiamine molecule | width2 = 260 <!--Clinical data--> | tradename = | Drugs.com = {{drugs.co..." |
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'''Prosultiamine''' ([[International Nonproprietary Name|INN]]; also known as '''thiamine propyl disulfide''' or '''TPD'''; brand name '''Jubedel''',) is a [[disulfide]] [[thiamine]] [[derivative (chemistry)|derivative]] discovered in garlic in [[Japan]] in the 1950s, and is similar to [[allithiamine]]. It was developed as a treatment for [[Thiamine#Deficiency|vitamin B<sub>1</sub> deficiency]]. It has improved [[lipid]] [[solubility]] relative to thiamine and is not rate-limited by dependency on intestinal [[membrane transport protein|transporter]]s for absorption, hence the reasoning for its development. | '''Prosultiamine''' ([[International Nonproprietary Name|INN]]; also known as '''thiamine propyl disulfide''' or '''TPD'''; brand name '''Jubedel''',) is a [[disulfide]] [[thiamine]] [[derivative (chemistry)|derivative]] discovered in garlic in [[Japan]] in the 1950s, and is similar to [[allithiamine]]. It was developed as a treatment for [[Thiamine#Deficiency|vitamin B<sub>1</sub> deficiency]]. It has improved [[lipid]] [[solubility]] relative to thiamine and is not rate-limited by dependency on intestinal [[membrane transport protein|transporter]]s for absorption, hence the reasoning for its development. | ||
==Research== | ==Research== <!--T:7--> | ||
It has been studied as a potential treatment for infection with [[human T-lymphotropic virus]] (HTLV), since it has been shown to reduce viral load and symptoms. | It has been studied as a potential treatment for infection with [[human T-lymphotropic virus]] (HTLV), since it has been shown to reduce viral load and symptoms. | ||
== See also == | == See also == <!--T:8--> | ||
* [[Vitamin B1 analogue|Vitamin B<sub>1</sub> analogue]] | * [[Vitamin B1 analogue|Vitamin B<sub>1</sub> analogue]] | ||
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{{Vitamins}} | {{Vitamins}} | ||
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{{二次利用|date=2 March 2024}} | {{二次利用|date=2 March 2024}} | ||
[[Category:Formamides]] | [[Category:Formamides]] | ||