Nifedipine: Difference between revisions

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==Side effects==

Nifedipine rapidly lowers blood pressure, and patients are commonly warned they may feel dizzy or faint after taking the first few doses. [[Tachycardia]] (fast heart rate) may occur as a reaction. These problems are much less frequent in the sustained-release preparations of nifedipine.~~{{medcn|date=January 2020}}~~

Nifedipine rapidly lowers blood pressure, and patients are commonly warned they may feel dizzy or faint after taking the first few doses. [[Tachycardia]] (fast heart rate) may occur as a reaction. These problems are much less frequent in the sustained-release preparations of nifedipine.

Extended release formulations of nifedipine should be taken on an empty stomach, and patients are warned not to consume anything containing [[grapefruit]] or grapefruit juice, as they raise blood nifedipine levels. There are several possible mechanisms, including the inhibition of [[CYP3A4]]-mediated metabolism.<ref>{{cite journal | vauthors = Odou P, Ferrari N, Barthélémy C, Brique S, Lhermitte M, Vincent A, Libersa C, Robert H | display-authors = 6 | title = Grapefruit juice-nifedipine interaction: possible involvement of several mechanisms | journal = Journal of Clinical Pharmacy and Therapeutics | volume = 30 | issue = 2 | pages = 153–8 | date = April 2005 | pmid = 15811168 | doi = 10.1111/j.1365-2710.2004.00618.x | s2cid = 30463290 | doi-access = free }}</ref>

Extended release formulations of nifedipine should be taken on an empty stomach, and patients are warned not to consume anything containing [[grapefruit]] or grapefruit juice, as they raise blood nifedipine levels. There are several possible mechanisms, including the inhibition of [[CYP3A4]]-mediated metabolism.

As calcium channel blocker, nifedipine has a risk of causing [[gingival hyperplasia]]~~<ref>{{Cite web|title=Nifedipine|url=https://bnf.nice.org.uk/drug/nifedipine.html|access-date=1 April 2021|website=NICE}}</ref>~~

As calcium channel blocker, nifedipine has a risk of causing [[gingival hyperplasia]]

==Overdose==

@@ Line 87: / Line 87: @@
 ==Side effects==
-Nifedipine rapidly lowers blood pressure, and patients are commonly warned they may feel dizzy or faint after taking the first few doses. [[Tachycardia]] (fast heart rate) may occur as a reaction. These problems are much less frequent in the sustained-release preparations of nifedipine.{{medcn|date=January 2020}}
+Nifedipine rapidly lowers blood pressure, and patients are commonly warned they may feel dizzy or faint after taking the first few doses. [[Tachycardia]] (fast heart rate) may occur as a reaction. These problems are much less frequent in the sustained-release preparations of nifedipine.
-Extended release formulations of nifedipine should be taken on an empty stomach, and patients are warned not to consume anything containing [[grapefruit]] or grapefruit juice, as they raise blood nifedipine levels. There are several possible mechanisms, including the inhibition of [[CYP3A4]]-mediated metabolism.<ref>{{cite journal | vauthors = Odou P, Ferrari N, Barthélémy C, Brique S, Lhermitte M, Vincent A, Libersa C, Robert H | display-authors = 6 | title = Grapefruit juice-nifedipine interaction: possible involvement of several mechanisms | journal = Journal of Clinical Pharmacy and Therapeutics | volume = 30 | issue = 2 | pages = 153–8 | date = April 2005 | pmid = 15811168 | doi = 10.1111/j.1365-2710.2004.00618.x | s2cid = 30463290 | doi-access = free }}</ref>
+Extended release formulations of nifedipine should be taken on an empty stomach, and patients are warned not to consume anything containing [[grapefruit]] or grapefruit juice, as they raise blood nifedipine levels. There are several possible mechanisms, including the inhibition of [[CYP3A4]]-mediated metabolism.
-As calcium channel blocker, nifedipine has a risk of causing [[gingival hyperplasia]]<ref>{{Cite web|title=Nifedipine|url=https://bnf.nice.org.uk/drug/nifedipine.html|access-date=1 April 2021|website=NICE}}</ref>
+As calcium channel blocker, nifedipine has a risk of causing [[gingival hyperplasia]]
 ==Overdose==