Pyridoxine/ja: Difference between revisions

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Created page with "<!-- Definition and medical uses --> '''ピリドキシン'''（'''Pyridoxine'''）は、ビタミンB<sub>6</sub>の一種で、食品によく含まれ、栄養補助食品として使用される。サプリメントとしては、ピリドキシン欠乏症、鉄芽球性貧血、ピリドキシン依存性てんかん、特定の..."
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'''Pyridoxine''', is a form of [[vitamin B6|vitamin B<sub>6</sub>]] found commonly in food and used as a [[dietary supplement]]. As a supplement it is used to treat and prevent [[pyridoxine deficiency]], [[sideroblastic anaemia]], [[pyridoxine-dependent epilepsy]], certain [[metabolic disorders]], side effects or complications of [[isoniazid]] use, and certain types of [[mushroom poisoning]]. It is used by mouth or by injection.
'''ピリドキシン'''（'''Pyridoxine'''）は、[[vitamin B6/ja|ビタミンB<sub>6</sub>]]の一種で、食品によく含まれ、[[dietary supplement/ja|栄養補助食品]]として使用される。サプリメントとしては、[[pyridoxine deficiency/ja|ピリドキシン欠乏症]]、[[sideroblastic anaemia/ja|鉄芽球性貧血]]、[[pyridoxine-dependent epilepsy/ja|ピリドキシン依存性てんかん]]、特定の[[metabolic disorders/ja|代謝異常]]、[[isoniazid/ja|イソニアジド]]使用の副作用または合併症、および特定のタイプの[[mushroom poisoning/ja|キノコ中毒]]を治療および予防するために使用される。経口または注射で使用される。
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It is usually well tolerated. Occasionally side effects include headache, numbness, and sleepiness. Normal doses are safe during [[pregnancy]] and [[breastfeeding]]. Pyridoxine is in the [[vitamin B]] family of vitamins. It is required by the body to metabolise [[amino acids]], [[carbohydrates]], and [[lipids]]. Sources in the diet include [[fruit]], [[vegetables]], and [[food grain|grain]].
通常、忍容性は良好である。時折、副作用として頭痛、しびれ、眠気が起こる。通常の用量であれば、[[pregnancy/ja|妊娠中]]や[[breastfeeding/ja|授乳中]]でも安全である。ピリドキシンはビタミンの[[vitamin B/ja|ビタミンB]]族に属する。体内で[[amino acids/ja|アミノ酸]]、[[carbohydrates/ja|炭水化物]]、[[lipids/ja|脂質]]を代謝するのに必要である。食事からの摂取源としては、[[fruit/ja|果物]]、[[vegetables/ja|野菜]]、[[food grain/ja|グレイン]]などがある。
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Revision as of 20:50, 3 April 2024

Other languages:
Pyridoxine/ja
ピリドキシン
Clinical data
Other namesvitamin B6, pyridoxol pyridoxine hydrochloride
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: Exempt
Routes of
administration		By mouth, intravenous (IV), intramuscular (IM), subcutaneous
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life数週間（詳細は#代謝を参照のこと）
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC8H11NO3
Molar mass169.180 g·mol−1
3D model (JSmol)
Melting point159 to 162 °C (318 to 324 °F)

ピリドキシン（Pyridoxine）は、ビタミンB6の一種で、食品によく含まれ、栄養補助食品として使用される。サプリメントとしては、ピリドキシン欠乏症、鉄芽球性貧血、ピリドキシン依存性てんかん、特定の代謝異常、イソニアジド使用の副作用または合併症、および特定のタイプのキノコ中毒を治療および予防するために使用される。経口または注射で使用される。

通常、忍容性は良好である。時折、副作用として頭痛、しびれ、眠気が起こる。通常の用量であれば、妊娠中や授乳中でも安全である。ピリドキシンはビタミンのビタミンB族に属する。体内でアミノ酸、炭水化物、脂質を代謝するのに必要である。食事からの摂取源としては、果物、野菜、グレインなどがある。

Medical uses

As a treatment (oral or injection), it is used to treat or prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, side effects of isoniazid treatment and certain types of mushroom poisoning. Isoniazid is an antibiotic used for the treatment of tuberculosis. Common side effect include numbness in the hands and feet. Co-treatment with vitamin B6 alleviates the numbness. Pyridoxine-dependent epilepsy is a type of rare infant epilepsy that does not improve with typical anti-seizure medications.

Pyridoxine in combination with doxylamine is used as a treatment for morning sickness in pregnant women.

Side effects

It is usually well tolerated, though overdose toxicity is possible. Occasionally side effects include headache, numbness, and sleepiness. Pyridoxine overdose can cause a peripheral sensory neuropathy characterized by poor coordination, numbness, and decreased sensation to touch, temperature, and vibration. Healthy human blood levels of pyridoxine are 2.1–21.7 ng/mL. Normal doses are safe during pregnancy and breastfeeding.

Mechanism

Pyridoxine is in the vitamin B family of vitamins. It is required by the body to make amino acids, carbohydrates, and lipids. Sources in the diet include fruit, vegetables, and grain. It is also required for muscle phosphorylase activity associated with glycogen metabolism.

Metabolism

The half-life of pyridoxine varies according to different sources: one source suggests that the half-life of pyridoxine is up to 20 days, while another source indicates half-life of vitamin B6 is in range of 25 to 33 days. After considering the different sources, it can be concluded that the half-life of pyridoxine is typically measured in several weeks.

History

Pyridoxine was discovered in 1934, isolated in 1938, and first made in 1939. It is on the World Health Organization's List of Essential Medicines. Pyridoxine is available both as a generic medication and over the counter product. Foods, such as breakfast cereal have pyridoxine added in some countries.

External links

  • Media related to Pyridoxine/ja at Wikimedia Commons
  • "Pyridoxine". Drug Information Portal. U.S. National Library of Medicine.
  • Pyridoxine mass spectrum
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