Vitamin B6/ja: Difference between revisions

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乳児の場合、ビタミンB6が不足すると、過敏症、異常に鋭敏な聴覚、けいれん発作を起こすことがある。

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~~Less severe cases present with metabolic disease associated with insufficient activity of the~~ [[coenzyme]] [[Pyridoxal phosphate|~~pyridoxal 5~~' ~~phosphate~~]] ~~(PLP). The most prominent of the lesions is due to impaired~~ [[tryptophan]]–[[Niacin (substance)|~~niacin~~]] ~~conversion. This can be detected based on urinary excretion of~~ [[xanthurenic acid]] ~~after an oral tryptophan load. Vitamin B~~6 ~~deficiency can also result in impaired~~ [[~~transsulfuration~~]] of [[~~methionine~~]] to [[~~cysteine~~]]~~. The PLP-dependent transaminases and glycogen phosphorylase provide the vitamin with its role in~~ [[gluconeogenesis]]~~, so deprivation of vitamin B~~6 ~~results in impaired~~ [[glucose tolerance]].

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 乳児の場合、ビタミンB<sub>6</sub>が不足すると、過敏症、異常に鋭敏な聴覚、けいれん発作を起こすことがある。
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+あまり重症でない場合は、[[coenzyme/ja|補酵素]][[Pyridoxal phosphate|ピリドキサール5'リン酸]]（PLP）の活性不足に伴う代謝性疾患を呈する。最も顕著な病変は、[[tryptophan/ja|トリプトファン]]-[[Niacin (substance)/ja|ナイアシン]]変換の障害によるものである。これは、経口トリプトファン負荷後の[[xanthurenic acid/ja|キサントウレン酸]]の尿中排泄に基づいて検出できる。ビタミンB<sub>6</sub>欠乏はまた、[[methionine/ja|メチオニン]]から[[cysteine/ja|システイン]]への[[transsulfuration/ja|トランス硫酸化]]の障害をもたらす。PLP依存性トランスアミナーゼとグリコーゲンホスホリラーゼはビタミンに[[gluconeogenesis/ja|糖新生]]における役割を与えるので、ビタミンB<sub>6</sub>の欠乏は[[glucose tolerance/ja|耐糖能]]障害をもたらす。
-Less severe cases present with metabolic disease associated with insufficient activity of the [[coenzyme]] [[Pyridoxal phosphate|pyridoxal 5' phosphate]] (PLP). The most prominent of the lesions is due to impaired [[tryptophan]]–[[Niacin (substance)|niacin]] conversion. This can be detected based on urinary excretion of [[xanthurenic acid]] after an oral tryptophan load. Vitamin B<sub>6</sub> deficiency can also result in impaired [[transsulfuration]] of [[methionine]] to [[cysteine]]. The PLP-dependent transaminases and glycogen phosphorylase provide the vitamin with its role in [[gluconeogenesis]], so deprivation of vitamin B<sub>6</sub> results in impaired [[glucose tolerance]].
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