Latest revision as of 20:36, 22 April 2024
Information about message (contribute ) This message has no documentation.
If you know where or how this message is used, you can help other translators by adding documentation to this message.
Message definition (Febuxostat ) === Pharmacokinetics === After oral intake, at least 84% of the febuxostat dose is absorbed in the gut, and highest [[blood plasma]] concentrations are reached after 60 to 90 minutes. When taken together with a fatty meal, febuxostat reaches lower concentrations in the body; but this is not considered clinically relevant. When in the bloodstream, 99.2% of the substance is bound to the plasma protein [[albumin]], and 82–91% of the [[active metabolite]]s are bound to plasma proteins.
薬物動態
経口摂取後、フェブキソスタット用量の少なくとも84%が腸管で吸収され、60~90分後に最高血漿中 濃度に達する。脂肪分の多い食事と一緒に摂取した場合、フェブキソスタットの体内濃度は低くなるが、これは臨床的な意義はないと考えられている。血中では、物質の99.2%が血漿タンパク質アルブミン と結合し、活性代謝物 の82~91%が血漿タンパク質と結合する。