Translations:Hydroxocobalamin/17/ja: Difference between revisions

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Created page with "==作用機序== {{Anchor|Mechanism of action}} ビタミンB<sub>12</sub>はコバラミンと呼ばれる化合物群を指し、人体内では様々な相互変換可能な形で存在する。コバラミンは葉酸とともに、染色体の複製と分裂が起こる細胞、特に骨髄と骨髄系細胞において、DNAの合成に必要な必須補因子である。Cofactor (bioch..."
 
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Latest revision as of 13:44, 7 April 2024

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Message definition (Hydroxocobalamin)
==Mechanism of action==
Vitamin B<sub>12</sub> refers to a group of compounds called cobalamins that are available in the human body in a variety of mostly interconvertible forms. Together with [[folate]], cobalamins are essential cofactors required for [[DNA]] synthesis in cells where [[chromosomal]] replication and division are occurring—most notably the [[bone marrow]] and [[myeloid]] cells. As a [[Cofactor (biochemistry)|cofactor]], cobalamins are essential for two cellular reactions:
*the mitochondrial [[methylmalonyl-CoA mutase]] conversion of [[methylmalonic acid]] (MMA) to [[succinate]], which links lipid and carbohydrate metabolism, and
*the activation of [[methionine synthase]], which is the rate-limiting step in the synthesis of [[methionine]] from [[homocysteine]] and [[5-methyltetrahydrofolate]].

作用機序

ビタミンB12はコバラミンと呼ばれる化合物群を指し、人体内では様々な相互変換可能な形で存在する。コバラミンは葉酸とともに、染色体の複製と分裂が起こる細胞、特に骨髄と骨髄系細胞において、DNAの合成に必要な必須補因子である。補因子として、コバラミンは2つの細胞反応に必須である：

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