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Message definition (Amino acid ) Non-proteinogenic amino acids that are found in proteins are formed by [[post-translational modification]]. Such modifications can also determine the localization of the protein, e.g., the addition of long hydrophobic groups can cause a protein to bind to a [[phospholipid]] membrane. Examples: *the [[carboxylation]] of [[glutamate]] allows for better binding of [[calcium in biology|calcium cations]], *[[Hydroxyproline]], generated by [[hydroxylation]] of [[proline]], is a major component of the [[connective tissue]] [[collagen]]. * [[Hypusine]] in the [[Eukaryotic initiation factor|translation initiation factor]] [[EIF5A]], contains a modification of lysine.
タンパク質に含まれる非タンパク質原性アミノ酸は、翻訳後修飾 によって形成される。このような修飾はタンパク質の局在を決定することもある。例えば、長い疎水基の付加はタンパク質をリン脂質 膜に結合させる。例としては