Translations:Angiotensin II receptor blocker/31/ja: Difference between revisions

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Created page with "{| class="wikitable" |+ 表1: ARB薬物動態の比較 |- ! 薬剤 ! 製品名 ! 半減期 [時間] ! ピーク血漿中濃度[Tmax] ! タンパク質結合率 [%] ! 生物学的利用能 [%] ! 腎／肝クリアランス [%] ! 食べ物の影響 ! 容量/日 [mg] ! 代謝/Transport protein/ja|トラ..."
 
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Latest revision as of 08:51, 27 March 2024

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Message definition (Angiotensin II receptor blocker)
{| class="wikitable"
|+ Table 1: Comparison of ARB [[pharmacokinetics]]
|-
! Drug
! Trade name
! [[Biological half-life]] [hrs]
! [[Cmax_(pharmacology)|Peak plasma concentration [Tmax] ]]
! [[Protein binding]] [%]
! [[Bioavailability]] [%]
! Renal/hepatic [[Clearance (medicine)|clearance]] [%]
! Food effect
! Daily dosage [mg]
! [[Metabolism]]/[[Transport protein|transporter]]
|-
| [[Losartan]]
| Cozaar
| 2 h
| 1 hr 
| 98.7%
| 33%
| 10/90%
| Minimal
| 50–100
| [[Sensitive substrates]]: [[CYP2C9]] and [[CYP3A4]]
|-
| [[Losartan#Pharmacokinetics|EXP 3174]] active metabolite of losartan
| -
| 6–9 hrs
| 3–4 hrs after oral losartan administration
| 99.8%
| –
| 50/50%
| –
| –
| AUC reduced by phenytoin and rifampin by 63% and 40% respectively; specific CYP450 isozymes are unknown
|-
| [[Candesartan]]
| Atacand
| 9
| 3–4 hrs
| >99%
| 15%
| 60/40%
| No
| 4–32
表1: ARB薬物動態の比較
薬剤 製品名 半減期 [時間] ピーク血漿中濃度[Tmax] タンパク質結合率 [%] 生物学的利用能 [%] 腎／肝クリアランス [%] 食べ物の影響 容量/日 [mg] 代謝/トランスポーター
ロサルタン Cozaar 2H 1H 98.7% 33% 10/90% ミネラル 50–100 センシティブ基質: CYP2C9とCYP3A4
EXP 3174 ロサルタンの活性代謝物 - 6–9H ロサルタン経口投与3–4H後 99.8% – 50/50% – – AUCはフェニトインで63％、リファンピンで40％減少する；特定のCYP450アイソザイムは不明
カンデサルタン Atacand 9 3–4H >99% 15% 60/40% No 4–32
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