Translations:Angiotensin II receptor blocker/31/en: Difference between revisions

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Message definition (Angiotensin II receptor blocker)
{| class="wikitable"
|+ Table 1: Comparison of ARB [[pharmacokinetics]]
|-
! Drug
! Trade name
! [[Biological half-life]] [hrs]
! [[Cmax_(pharmacology)|Peak plasma concentration [Tmax] ]]
! [[Protein binding]] [%]
! [[Bioavailability]] [%]
! Renal/hepatic [[Clearance (medicine)|clearance]] [%]
! Food effect
! Daily dosage [mg]
! [[Metabolism]]/[[Transport protein|transporter]]
|-
| [[Losartan]]
| Cozaar
| 2 h
| 1 hr 
| 98.7%
| 33%
| 10/90%
| Minimal
| 50–100
| [[Sensitive substrates]]: [[CYP2C9]] and [[CYP3A4]]
|-
| [[Losartan#Pharmacokinetics|EXP 3174]] active metabolite of losartan
| -
| 6–9 hrs
| 3–4 hrs after oral losartan administration
| 99.8%
| –
| 50/50%
| –
| –
| AUC reduced by phenytoin and rifampin by 63% and 40% respectively; specific CYP450 isozymes are unknown
|-
| [[Candesartan]]
| Atacand
| 9
| 3–4 hrs
| >99%
| 15%
| 60/40%
| No
| 4–32
Table 1: Comparison of ARB pharmacokinetics
Drug Trade name Biological half-life [hrs] Peak plasma concentration [Tmax] Protein binding [%] Bioavailability [%] Renal/hepatic clearance [%] Food effect Daily dosage [mg] Metabolism/transporter
Losartan Cozaar 2 h 1 hr 98.7% 33% 10/90% Minimal 50–100 Sensitive substrates: CYP2C9 and CYP3A4
EXP 3174 active metabolite of losartan - 6–9 hrs 3–4 hrs after oral losartan administration 99.8% – 50/50% – – AUC reduced by phenytoin and rifampin by 63% and 40% respectively; specific CYP450 isozymes are unknown
Candesartan Atacand 9 3–4 hrs >99% 15% 60/40% No 4–32
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