Translations:Angiotensin II receptor blocker/31/en

Table 1: Comparison of ARB pharmacokinetics

Drug	Trade name	Biological half-life [hrs]	Peak plasma concentration [Tmax]	Protein binding [%]	Bioavailability [%]	Renal/hepatic clearance [%]	Food effect	Daily dosage [mg]	Metabolism/transporter
Losartan	Cozaar	2 h	1 hr	98.7%	33%	10/90%	Minimal	50–100	Sensitive substrates: CYP2C9 and CYP3A4
EXP 3174 active metabolite of losartan	-	6–9 hrs	3–4 hrs after oral losartan administration	99.8%	–	50/50%	–	–	AUC reduced by phenytoin and rifampin by 63% and 40% respectively; specific CYP450 isozymes are unknown
Candesartan	Atacand	9	3–4 hrs	>99%	15%	60/40%	No	4–32