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Message definition (Low-density lipoprotein ) Another lifestyle approach to reduce LDL cholesterol has been minimizing total body fat, in particular fat stored inside the [[abdominal cavity]] ([[Adipose tissue|visceral body fat]]). Visceral fat, which is more metabolically active than subcutaneous fat, has been found to produce many enzymatic signals, e.g. [[resistin]], which increase [[insulin resistance]] and circulating VLDL particle concentrations, thus both increasing LDL particle concentrations and accelerating the development of diabetes mellitus.
LDLコレステロールを減少させるためのもう一つのライフスタイルのアプローチは、総体脂肪、特に腹腔 内に蓄積された脂肪（内臓脂肪 ）を最小限に抑えることである。皮下脂肪よりも代謝活性の高い内臓脂肪は、多くの酵素シグナル、例えばレジスチン を産生し、インスリン抵抗性 と循環VLDL粒子濃度を増加させ、その結果LDL粒子濃度を増加させ、糖尿病の発症を促進させることがわかっている。