Sodium/glucose cotransporter 2: Difference between revisions

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox gene}}

The '''sodium/glucose cotransporter 2''' (SGLT2) is a [[protein]] that in humans is encoded by the {{gene|SLC5A2}} (solute carrier family 5 (sodium/glucose cotransporter)) [[gene]].

SGLT2 is a member of the [[sodium-glucose transport proteins|sodium glucose cotransporter family]], which are sodium-dependent [[glucose]] transport proteins. SGLT2 is the major cotransporter involved in glucose [[reabsorption]] in the kidney.  SGLT2 is located in the early [[proximal tubule]], and is responsible for reabsorption of 80-90% of the glucose filtered by the kidney [[Glomerulus (kidney)|glomerulus]]. Most of the remaining glucose absorption is by [[sodium/glucose cotransporter 1]] (SGLT1) in more distal sections of the proximal tubule.

{{Main|SGLT2 inhibitor}}

[[SGLT2 inhibitor]]s are also called gliflozins or flozins. They lead to a reduction in blood glucose levels, and therefore have potential use in the treatment of [[type 2 diabetes]]. Gliflozins enhance glycemic control as well as reduce [[Human body weight|body weight]] and systolic and diastolic [[blood pressure]]. The gliflozins canagliflozin, dapagliflozin, and empagliflozin may lead to euglycemic [[ketoacidosis]]. Other side effects of gliflozins include increased risk of Fournier gangrene

Mutations in this gene are also associated with [[renal glycosuria]].

* [[SGLT]] Family

* [[Discovery and development of gliflozins]]

* [[Phlorizin]] — a competitive inhibitor of [[SLC5A1|SGLT1]] and [[SGLT2]]

{{reflist|33em}}

{{refbegin|33em}}

* {{cite journal | vauthors = van den Heuvel LP, Assink K, Willemsen M, Monnens L | title = Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2) | journal = Human Genetics | volume = 111 | issue = 6 | pages = 544–7 | date = Dec 2002 | pmid = 12436245 | doi = 10.1007/s00439-002-0820-5 | s2cid = 28089635 }}

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{{Solute carrier family|bg|bg0}}

{{Sodium-glucose transporter modulators}}

{{二次利用|date=18 December 2023}}

[[Category:Solute carrier family]]

[[Category:Genes mutated in mice]]